Matthias Löhr
Karolinska University Hospital
CancerInternal medicineEndocrinologySurgeryPathologyOncologyCA19-9ChemistryPancreatitisChemotherapyPancreatic diseasePancreasPancreatic ductPancreatic cancerAdenocarcinomaCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 287
#1Dhifaf SarhanH-Index: 16
#2Fei HeH-Index: 1
Last. Mikael C. I. KarlssonH-Index: 32
view all 11 authors...
BACKGROUND AND AIMS The overall evidence on the association between gallbladder conditions (GBC: gallstones and cholecystectomy) and pancreatic cancer (PC) is inconsistent. To our knowledge, no previous investigations considered the role of tumour characteristics on this association. Thus, we aimed to assess the association between self-reported GBC and PC risk, by focussing on timing to PC diagnosis and tumour features (stage, location, and resection). METHODS Data derived from a European case-...
#1Beate Gündel (KI: Karolinska Institutet)H-Index: 1
#2Xinyuan Liu (KI: Karolinska Institutet)H-Index: 1
Last. Rainer Heuchel (KI: Karolinska Institutet)H-Index: 32
view all 4 authors...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most overlooked cancers despite its dismal median survival time of 6 months. The biggest challenges in improving patient survival are late diagnosis due to lack of diagnostic markers, and limited treatment options due to almost complete therapy resistance. The past decades of research identified the dense stroma and the complex interplay/crosstalk between the cancer- and the different stromal cells as the main culprits for the slow progress i...
#1Jingru Yu (KI: Karolinska Institutet)H-Index: 6
#2Huan SongH-Index: 24
Last. Weimin Ye (KI: Karolinska Institutet)H-Index: 91
view all 6 authors...
Background: null It remains open whether gastric precancerous lesions are associated with an elevated risk of pancreatic cancer. Our aim was to investigate the association between gastric mucosal status and pancreatic cancer risk. null Methods: null Patients with gastric biopsies [normal, minor changes, superficial gastritis, and atrophic gastritis/intestinal metaplasia/dysplasia (AG/IM/Dys)] from the Swedish histopathology registers during 1979 to 2011 were included. Cross-linkages with several...
#1Patrick MichlH-Index: 34
#2Matthias Löhr (Karolinska University Hospital)H-Index: 58
Last. Luigi Ricciardiello (UNIBO: University of Bologna)H-Index: 36
view all 8 authors...
BACKGROUND Pancreatic ductal adenocarcinoma is the deadliest cancer worldwide with a 98% loss-of-life expectancy and a 30% increase in the disability-adjusted life years during the last decade in Europe. The disease cannot be effectively prevented nor being early detected. When diagnosed, 80% of patients have tumors that are in incurable stages, while for those who undergo surgery, 80% of patients will present with local or distant metastasis. Importantly, chemotherapies are far from being effec...
#2Livia Archibugi (UniSR: Vita-Salute San Raffaele University)H-Index: 14
Last. Enrique de-MadariaH-Index: 20
view all 25 authors...
OBJECTIVES post-endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis (PEP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non-steroidal anti-inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic-acid (ASA) treatment is unclear. We aimed to investigate whether statins and chronic ASA intake are assoc...
#1Xinyuan Liu (KI: Karolinska Institutet)H-Index: 1
#2Beate Gündel (KI: Karolinska Institutet)H-Index: 1
Last. Rainer Heuchel (KI: Karolinska Institutet)H-Index: 32
view all 8 authors...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, partly due to the dense desmoplasia and a lack of suitable model systems to study. In the present work, we developed a 3D heterospecies spheroid model to study the microenvironmental interactions between tumor cells and stellate cells which can also be employed to test therapeutic regimens. We set up monospheroids and heterospheroids made up from murine pancreatic stellate cells (mPSCs) and human PDAC cells ...
#1Jingru Yu (KI: Karolinska Institutet)H-Index: 6
#2Alexander Ploner (KI: Karolinska Institutet)H-Index: 36
Last. Weimin Ye (KI: Karolinska Institutet)H-Index: 91
view all 13 authors...
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC patients (early PDAC, stage I/II, n = 71; advanced PDAC, stage III/IV, n = 64), 13 benign lesions/chronic pancreatitis patients, and 72 healthy individuals, with corresponding plasma samples from a case-control study in Sweden were included. A Proximity Extension Assay was ...
#2Wookyeong Song (UPR-RP: UPRRP College of Natural Sciences)H-Index: 1
#3Wonho Choo (UPR-RP: UPRRP College of Natural Sciences)H-Index: 3
BACKGROUND Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms. METHODS We recruited 3708 patients who underwent surgi...
#1Lotte Boxhoorn (UvA: University of Amsterdam)H-Index: 3
Last. Hjalmar C. van Santvoort (UU: Utrecht University)H-Index: 58
view all 67 authors...
Abstract Background Pancreatic duct disruption or disconnection is a potentially severe complication of necrotizing pancreatitis. With no existing treatment guidelines, it is unclear whether there is any consensus among experts in clinical practice. We evaluated current expert opinion regarding the diagnosis and treatment of pancreatic duct disruption and disconnection in an international case vignette study. Methods An online case vignette survey was sent to 110 international expert pancreatolo...
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