Matthias Löhr
Karolinska University Hospital
CancerInternal medicineEndocrinologySurgeryPathologyOncologyCA19-9Molecular biologyChemistryPancreatitisChemotherapyPancreatic diseasePancreasPancreatic ductPancreatic cancerAdenocarcinomaCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 280
#2Livia Archibugi (UniSR: Vita-Salute San Raffaele University)H-Index: 13
Last. Enrique de-MadariaH-Index: 18
view all 25 authors...
OBJECTIVES post-endoscopic retrograde cholangiopancreatography (ERCP) acute pancreatitis (PEP) is a frequent complication of this endoscopic procedure. Chronic statin intake has been linked to lower incidence and severity of acute pancreatitis (AP). Periprocedural rectal administration of non-steroidal anti-inflammatory drugs is protective against PEP, but the role of chronic acetylsalicylic-acid (ASA) treatment is unclear. We aimed to investigate whether statins and chronic ASA intake are assoc...
1 CitationsSource
#1Xinyuan Liu (KI: Karolinska Institutet)
#2Beate Gündel (KI: Karolinska Institutet)
Last. Rainer Heuchel (KI: Karolinska Institutet)H-Index: 31
view all 8 authors...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, partly due to the dense desmoplasia and a lack of suitable model systems to study. In the present work, we developed a 3D heterospecies spheroid model to study the microenvironmental interactions between tumor cells and stellate cells which can also be employed to test therapeutic regimens. We set up monospheroids and heterospheroids made up from murine pancreatic stellate cells (mPSCs) and human PDAC cells ...
#1Jingru Yu (KI: Karolinska Institutet)H-Index: 6
#2Alexander Ploner (KI: Karolinska Institutet)H-Index: 34
Last. Weimin Ye (KI: Karolinska Institutet)H-Index: 89
view all 13 authors...
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC patients (early PDAC, stage I/II, n = 71; advanced PDAC, stage III/IV, n = 64), 13 benign lesions/chronic pancreatitis patients, and 72 healthy individuals, with corresponding plasma samples from a case-control study in Sweden were included. A Proximity Extension Assay was ...
#1Hyeong Seok Kim (New Generation University College)H-Index: 4
#2Wookyeong Song (UPR-RP: UPRRP College of Natural Sciences)
Last. Jin-Young Jang (New Generation University College)H-Index: 54
view all 57 authors...
BACKGROUND Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms. METHODS We recruited 3708 patients who underwent surgi...
BACKGROUND: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% of the phenotypic variance. METHODS: We complemented a new conventional PC GWAS (1D) with genome spatial autocorrelation analysis (2D) permitting to prioritize low frequency variants not detected by GWAS. These were further expanded via Hi-C map (3D) interactions to gain additio...
#1Lotte Boxhoorn (UvA: University of Amsterdam)H-Index: 3
Last. Nicholas J. ZyromskiH-Index: 35
view all 67 authors...
Abstract Background Pancreatic duct disruption or disconnection is a potentially severe complication of necrotizing pancreatitis. With no existing treatment guidelines, it is unclear whether there is any consensus among experts in clinical practice. We evaluated current expert opinion regarding the diagnosis and treatment of pancreatic duct disruption and disconnection in an international case vignette study. Methods An online case vignette survey was sent to 110 international expert pancreatolo...
#1Jae Seung Kang (SNU: Seoul National University)H-Index: 1
#2Chanhee Lee (SNU: Seoul National University)H-Index: 1
Last. Jin Young Jang (SNU: Seoul National University)
view all 61 authors...
Most models for predicting malignant pancreatic intraductal papillary mucinous neoplasms were developed based on logistic regression (LR) analysis. Our study aimed to develop risk prediction models using machine learning (ML) and LR techniques and compare their performances. This was a multinational, multi-institutional, retrospective study. Clinical variables including age, sex, main duct diameter, cyst size, mural nodule, and tumour location were factors considered for model development (MD). ...
1 CitationsSource
Last. Rainer HeuchelH-Index: 31
view all 7 authors...
#1Livia ArchibugiH-Index: 13
#2G CiarfagliaH-Index: 1
Last. G. CapursoH-Index: 2
view all 25 authors...
#1Ana DugicH-Index: 1
#2Sara NikolicH-Index: 2
Last. Miroslav VujasinovicH-Index: 13
view all 8 authors...