Mark A. Lawson
University of California, San Diego
Internal medicineEndocrinologyMagnetic resonance imagingPerfusionGene expressionMolecular biologyCardiologyRegulation of gene expressionChemistryGonadotropic cellCardiac magnetic resonance imagingHeart failureGonadotropinCardiomyopathyGonadotropin-releasing hormoneNuclear medicineSignal transductionHormoneMedicineEjection fractionBiologyCell biology
93Publications
25H-index
1,622Citations
Publications 90
Newest
#1Olivia Molinar-Inglis (UCSD: University of California, San Diego)H-Index: 3
#2Cierra A. Birch (UCSD: University of California, San Diego)H-Index: 1
Last. JoAnn TrejoH-Index: 50
view all 13 authors...
Endothelial dysfunction is associated with multiple vascular diseases and lacks effective treatment options. Activated Protein C (aPC) is a promising biotherapeutic that signals via protease-activated receptor-1 (PAR1) to promote diverse cytoprotective responses, including endothelial barrier stabilization, anti-inflammatory, and anti-apoptotic activities, which require specific co-receptors. We show that aPC-activated PAR1 signals preferentially via {beta}-arrestin-2 ({beta}-arr2) and dishevell...
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#1Mark A. Lawson (VUMC: Vanderbilt University Medical Center)H-Index: 25
#2David E. Hansen (VUMC: Vanderbilt University Medical Center)H-Index: 1
Last. Marvin W. Kronenberg (VUMC: Vanderbilt University Medical Center)H-Index: 18
view all 9 authors...
AIMS We sought to clarify the role of ventriculo-arterial (V-A) coupling in the treatment of nonischemic dilated cardiomyopathy (NIDCM) by adding a mineralocorticoid receptor antagonist (MRA) to conventional anti-failure therapy. METHODS AND RESULTS We employed cardiac magnetic resonance imaging to quantify left ventricular (LV) contractility and V-A coupling in normal subjects at rest (n = 11) and in patients with NIDCM (n = 12) before and after long term anti-failure therapy, in which MRA was ...
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#1Lourdes A Esparza (UCSD: University of California, San Diego)H-Index: 3
#1Lourdes A. Esparza (UCSD: University of California, San Diego)H-Index: 7
Last. Alexander S. Kauffman (UCSD: University of California, San Diego)H-Index: 37
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Androgens can affect the reproductive axis of both sexes. In healthy women, as in men, elevated exogenous androgens decrease gonad function and lower gonadotropin levels; such circumstances occur with anabolic steroid abuse or in transgender men (genetic XX individuals) taking androgen supplements. The neuroendocrine mechanisms by which endogenous or exogenous androgens regulate gonadotropin release, including aspects of pulsatile luteinizing hormone (LH) secretion, remain unknown. Because anima...
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#1Daniel E. ClarkH-Index: 6
#1Daniel E. Clark (Vandy: Vanderbilt University)H-Index: 1
Last. Marvin W. KronenbergH-Index: 18
view all 8 authors...
Introduction: Dilated cardiomyopathy (DCM) is associated with impaired myocardial perfusion reserve and impaired myocardial oxidative metabolism. However, the association between myocardial perfusi...
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#1Verónica A. Segarra (High Point University)H-Index: 7
#2Clara Primus (High Point University)H-Index: 1
Last. Marina Ramirez-Alvarado (Mayo Clinic)H-Index: 34
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Scientific societies aiming to foster inclusion of scientists from underrepresented (UR) backgrounds among their membership often delegate primary responsibility for this goal to a diversity-focuse...
2 CitationsSource
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. Knight (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression in a pituitary gonadotrope cell model and in primary gonadotropes, we show GLUT1-dependent stimulation of glycolysis, but not mitochondrial respiration, by the reproductive neuropeptide GnRH. GnRH stimulation increases gonadotrope GLUT1...
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#1Verónica A. Segarra (High Point University)H-Index: 7
#2Leticia R. Vega (Barry University)H-Index: 2
Last. Marina Ramirez-Alvarado (Mayo Clinic)H-Index: 34
view all 20 authors...
This essay compares the approaches that scientific societies in the ACCESS meta-organization use to implement and assess travel award programs for URM trainees and presents a set of recommendations...
7 CitationsSource
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. KnightH-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
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#1Olivia Molinar-Inglis (UCSD: University of California, San Diego)H-Index: 3
#2Lili Zhang (UCSD: University of California, San Diego)
Last. JoAnn Trejo (UCSD: University of California, San Diego)H-Index: 50
view all 12 authors...
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#1Alexis Garcia (UCSD: University of California, San Diego)
#2Olivia Molinar-Inglis (UCSD: University of California, San Diego)H-Index: 3
Last. JoAnn Trejo (UCSD: University of California, San Diego)H-Index: 50
view all 9 authors...
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