Weina Zhao
University of Texas Health Science Center at Houston
CancerMembrane fluidityPhenotypeCellGene expressionSystems biologyImmunologyIn vivoABCA1Cell membraneCholesterolMetastasisStem cellCancer researchBreast cancerMotilityBioinformaticsSignal transductionMedicineEpithelial–mesenchymal transitionLipid raftBiologyRaftCell biologyCancer cell
4Publications
3H-index
80Citations
Publications 4
Newest
#1Michael J. Tisza (University of Texas Health Science Center at Houston)H-Index: 7
#2Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
Last. Jeffrey T. Chang (University of Texas Health Science Center at Houston)H-Index: 41
view all 7 authors...
// Michael J. Tisza 1, * , Weina Zhao 1, * , Jessie S.R. Fuentes 1, * , Sara Prijic 1 , Xiaoling Chen 1 , Ilya Levental 1 , Jeffrey T. Chang 1, 2 1 Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX, USA 2 Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA * These authors have contributed equally to this work Correspondence to: Ilya Levental, email: ilya...
21 CitationsSource
#1Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
#2Sara Prijic (University of Texas Health Science Center at Houston)H-Index: 6
Last. Jeffrey T. ChangH-Index: 41
view all 10 authors...
Despite the high mortality from metastatic cancer, therapeutic targets to prevent metastasis are limited. Efforts to identify genetic aberrations that predispose tumors to metastasis have been mostly unsuccessful. To understand the nature of candidate targets for metastatic disease, we performed an in silico screen to identify drugs that can inhibit a gene expression signature associated with epithelial–mesenchymal transition (EMT). Compounds discovered through this method, including those previ...
57 CitationsSource
#1Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
#2Prijic Sara (University of Texas Health Science Center at Houston)
Last. Jeffrey T. Chang (University of Texas Health Science Center at Houston)H-Index: 41
view all 6 authors...
New therapeutic targets that can inhibit cancer metastasis are desperately needed. To address this issue, we have leveraged a computational approach and performed an unbiased screen for therapies that can inhibit an epithelial-to-mesenchymal transition (EMT) gene expression profile, a phenotype that is believed to promote metastases. This yielded predictions of drugs that can both promote and inhibit an EMT transcriptional profile. Following up on these predictions, we confirmed experimentally t...
Source
#1Weina Zhao (University of Texas Health Science Center at Houston)H-Index: 3
#2Michael J. Tisza (University of Texas Health Science Center at Houston)H-Index: 7
Last. Jeffrey T. Chang (University of Texas Health Science Center at Houston)H-Index: 41
view all 5 authors...
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA New therapeutic targets that can inhibit cancer metastasis are desperately needed. To address this issue, we have leveraged a computational approach and performed an unbiased screen for therapies that can inhibit an epithelial-to-mesenchymal transition (EMT) gene expression profile, a phenotype that is believed to promote metastases. This yielded predictions of drugs that can both promote and inhibit an EMT transcriptional pro...
3 CitationsSource