Suna Kim
Kyung Hee University
CellTumor necrosis factor alphaApoptosisMesenchymal stem cellImmunologySystemic inflammationInflammationRetinal pigment epitheliumCytokineBone marrowRetinalRetinal degenerationStem cellCytokine secretionCancer researchIschemiaMedicineBiologyCell biologyPharmacology
16Publications
7H-index
102Citations
Publications 16
Newest
#1Suna Kim (Kyung Hee University)H-Index: 7
#2Hyun Sook Hong (Kyung Hee University)H-Index: 11
Abstract Substance-P (SP) is a neuropeptide that modulates immune responses and accelerates tissue repair in critical inflammatory disease. Liver fibrosis and cirrhosis are the ultimate outcomes of almost all chronic liver diseases caused by viral infection, steatohepatitis, autoimmune, and cholestatic injury. Despite the development of new drugs, liver transplantation is still the only fundamental treatment; thus, new therapeutic approaches to mitigate liver fibrosis and chronic inflammation ar...
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#1Sang-Min Baek (Kyung Hee University)H-Index: 1
#2Ki-Young Kim (Kyung Hee University)H-Index: 17
Last. Seung-Young Yu (Kyung Hee University)H-Index: 12
view all 6 authors...
Type 2 diabetic mellitus (T2DM) is characterized by systemic inflammation and insulin resistance due to obesity, and this leads to critical complications, including retinopathy and nephropathy. This study explored the therapeutic effect of substance-p (SP), a neuropeptide, on T2DM progression and its complications. To examine whether SP affects glucose metabolism, lipid metabolism, systemic inflammation, and retinopathy, Otsuka Long-Evans Tokushima Fatty rats (OLETF, 27 weeks old) with chronic i...
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#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 4 authors...
Bone marrow mesenchymal stem cell (MSC) therapy acts through multiple differentiations in damaged tissue or via secretion of paracrine factors, as demonstrated in various inflammatory and ischaemic diseases. However, long-term ex vivo culture to obtain a sufficient number of cells in MSC transplantation leads to cellular senescence, deficiency of the paracrine potential, and loss of survival rate post-transplantation. In this study, we evaluated whether supplementation of MSCs with substance P (...
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#1Seungwoo Nam (Kyung Hee University)H-Index: 5
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 5 authors...
Use of bone marrow aspirate (BMA) is a clinically advantageous cell therapeutic that bypasses the need for elaborate ex vivo cell culturing. However, a low level of bone marrowmesenchymal stem cells (BMMSCs) in the BMA and weak survival rate of these cells posttransplantation entails an insufficient efficacy in vivo. Moreover, stem cell activity in BMA is impaired by age or background diseases. Thus, in order to enrich the BMMSC pool and improve cell survival, novel cell preconditioning technolo...
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#1Hyun Ji Park (Yonsei University)H-Index: 16
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Seung Woo Cho (Yonsei University)H-Index: 51
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Abstract Substance P (SP) is a therapeutic peptide that has been widely used to induce angiogenesis and tissue regeneration. However, its therapeutic efficacy is often limited due to rapid degradation in vivo and a short half-life (˜1 min) after systemic administration. In the present study, we chemically modified SP with polyethylene glycol (PEG) to generate long-lasting formulations with increased stability and extended retention time in vivo and evaluated their ability to enhance therapeutic ...
3 CitationsSource
#1Suna Kim (Kyung Hee University)H-Index: 7
#2Jiyuan Piao (Kyung Hee University)H-Index: 4
Last. Hyun Sook Hong (Kyung Hee University)H-Index: 11
view all 6 authors...
Abstract Aims Arterial insufficiency ulcers are frequent complications of peripheral artery disease and infection or long-term neglect of the ulcer can eventually lead to amputation of the affected body part. An ischemic environment, caused by interrupted blood flow, affects the supply of nutrients and elongates the inflammation period, inducing tissue degeneration. Thus, the modulation of neovascularization and inflammation could be an ideal therapeutic strategy for ischemic wound healing. This...
5 CitationsSource
#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Weon Kim (Kyung Hee University)H-Index: 18
view all 8 authors...
BACKGROUND/AIMS: Therapies using stem/progenitor cells have been experimentally and clinically investigated to regenerate damaged hearts. Substance-P (SP) induces bone marrow (BM) stem cell mobilization and suppresses inflammation in ischemic injuries. This study investigated the role of SP in BM stem cell mobilization and immune responses for tissue repair after ischemic-reperfusion injury (IRI), in comparison with that of granulocyte colony-stimulating factor (GCSF). METHODS: SP was intravenou...
7 CitationsSource
#1Eun Jung Seo (Kyung Hee University)H-Index: 2
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Hyun Sook Hong (Kyung Hee University)H-Index: 11
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Abstract Aims Excessive alcohol consumption induces hepatic injury and promotes lipid accumulation, events involved in the pathogenesis of serious conditions such as alcoholic liver disease (ALD). Thus, protection of hepatocytes against alcohol-induced death is considered to be a critical approach to prevent development of liver disease. Substance P (SP) is capable of promoting cell proliferation and blocking cell death under diverse stresses, leading to beneficial effects in severe diseases, an...
3 CitationsSource
#1Dae Yeon Hwang (Kyung Hee University)H-Index: 3
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Hyun Sook Hong (Kyung Hee University)H-Index: 11
view all 3 authors...
Intestinal inflammation alters immune responses in the mucosa and destroys colon architecture, leading to serious diseases such as inflammatory bowel disease. Thus, the modulation of intestinal integrity and immune responses in IBD can be the critical factor to be considered to reduce the severity of damages. Substance-P (SP), endogenous peptide to be involved in cell proliferation, migration and immune modulation, can exert the therapeutic effect on diverse diseases including cornea damage, rhe...
7 CitationsSource
#1Kyungsang Yoo (Kyung Hee University)H-Index: 3
#2Bo Kwon Son (Kyung Hee University)H-Index: 3
Last. Hyun Sook Hong (Kyung Hee University)H-Index: 11
view all 6 authors...
Purpose: Proliferative vitreoretinopathy (PVR) is an inflammatory fibrotic disease resulting from the inflammatory milieu after retinal detachment, which can prevent retinal healing. This study aimed to elucidate the effect of substance P (SP) on retinal degeneration caused by retinal detachment in vivo and to examine the role of SP in the tumor necrosis factor-alpha (TNF-α)-induced epithelial-mesenchymal transition (EMT) of human RPE cells in vitro. Methods: PVR-like retinal damage was induced ...
9 Citations