Catharine M L West
University of Manchester
Genome-wide association studyClonogenic assayCancerInternal medicineSurgeryPathologyOncologyRadiogenomicsRadiosensitivityHead and neck cancerCarcinomaCervixHypoxia (medical)Prostate cancerToxicityNuclear medicineCancer researchRadiation therapyBreast cancerMedicineBiology
Publications 403
#1B. Bibby (University of Manchester)H-Index: 2
#2N. Thiruthaneeswaran (USYD: University of Sydney)H-Index: 4
Last. Ananya Choudhury (University of Manchester)H-Index: 28
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BACKGROUND The presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance. There is potential for drug radiotherapy combinations to improve the therapeutic ratio. We aimed to investigate whether hypoxia-associated genes could be used to identify FDA approved drugs for repurposing for the treatment of hypoxic prostate cancer. METHODS Hypoxia associated genes were identified and used in the connectivity mapping software QUADrA...
#1N. Thiruthaneeswaran (University of Manchester)H-Index: 4
#2B. Bibby (University of Manchester)H-Index: 2
Last. Catharine M L West (University of Manchester)H-Index: 77
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The history of radiotherapy is intertwined with research on hypoxia. There is level 1a evidence that giving hypoxia-targeting treatments with radiotherapy improves locoregional control and survival without compromising late side-effects. Despite coming in and out of vogue over decades, there is now an established role for hypoxia in driving molecular alterations promoting tumour progression and metastases. While tumour genomic complexity and immune profiling offer promise, there is a stronger ev...
#1Anna-Maria Tsakiroglou (MAHSC: Manchester Academic Health Science Centre)
#2Susan M. Astley (University of Manchester)H-Index: 26
Last. Kim Linton (MAHSC: Manchester Academic Health Science Centre)H-Index: 19
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Background Follicular lymphoma (FL) prognosis is influenced by the composition of the tumour microenvironment. We tested an automated approach to quantitatively assess the phenotypic and spatial immune infiltrate diversity as a prognostic biomarker for FL patients. Methods Diagnostic biopsies were collected from 127 FL patients initially treated with rituximab-based therapy (52%), radiotherapy (28%), or active surveillance (20%). Tissue microarrays were constructed and stained using multiplex im...
#1Mairah T Khan (MAHSC: Manchester Academic Health Science Centre)H-Index: 1
#2Joely J Irlam-Jones (MAHSC: Manchester Academic Health Science Centre)H-Index: 1
Last. Catharine M L West (MAHSC: Manchester Academic Health Science Centre)H-Index: 77
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Background miRNAs are promising biomarkers in oncology as their small size makes them less susceptible to degradation than mRNA in FFPE tissue. We aimed to derive a hypoxia-associated miRNA signature for bladder cancer. Methods Taqman miRNA array cards identified miRNA seed genes induced under hypoxia in bladder cancer cell lines. A signature was derived using feature selection methods in a TCGA BLCA training data set. miRNA expression data were generated for 190 tumours from the BCON Phase 3 tr...
#1Nicola Rares Franco (Ghent University Hospital)
#1Nicola Rares Franco (Ghent University Hospital)H-Index: 1
Last. Tiziana RancatiH-Index: 27
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AIM To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi). MATERIALS AND METHODS Analysis included the REQUITE PCa cohort that received external beam RT and was followed for 2 years. Late toxicity endpoints were: rectal bleeding, urinary frequency, haematuria, nocturia, decreased urinary stream. Among 43 li...
#1J. Price (University of Manchester)H-Index: 1
#2Catharine M L West (University of Manchester)H-Index: 77
Last. David J Thomson (University of Manchester)H-Index: 11
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Abstract Purpose For oropharynx squamous cell carcinoma (OPSCC) this study aimed to: (i) compare 5-year overall survival (OS) stratification by AJCC/UICC TNM versions 7 (TNMv7) and 8 (TNMv8), (ii) determine whether changes to T and N stage groupings improve prognostication and (iii) develop and validate a model incorporating additional clinical characteristics to improve 5-year OS prediction. Material and Methods All OPSCC treated with curative-intent at our institution between 2011 and 2017 wer...
#1David T. Miyamoto (Harvard University)H-Index: 29
#2Philip Abbosh (Fox Chase Cancer Center)H-Index: 9
Last. Kent W. Mouw (Brigham and Women's Hospital)H-Index: 22
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Muscle-invasive bladder cancer can be treated with either radical cystectomy or bladder preservation approaches, and there is a need for reliable biomarkers to guide the optimal choice of therapy. The recent elucidation of the genomic landscape and biological drivers of bladder cancer has enabled the identification of tumor molecular features that may be helpful in driving clinical decision-making. Here, we summarize recent efforts to develop molecular biomarkers that could be leveraged to guide...
1 CitationsSource
#1T. Lodhi (MAHSC: Manchester Academic Health Science Centre)H-Index: 1
#2Yee Pei Song (MAHSC: Manchester Academic Health Science Centre)H-Index: 2
Last. Ananya Choudhury (MAHSC: Manchester Academic Health Science Centre)H-Index: 28
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Abstract Radiotherapy plays an essential role in the curative treatment of muscle-invasive bladder cancer (MIBC). Hypoxia affects the response to MIBC radiotherapy, limiting radiocurability. Likewise, hypoxia influences MIBC genetic instability and malignant progression being associated with metastatic disease and a worse prognosis. Hypoxia identification in MIBC enables treatment stratification and the promise of improved survival. The most promising methods are histopathological markers such a...
1 CitationsSource
#1Yee Pei Song (University of Manchester)H-Index: 4
#2Hitesh Mistry (University of Manchester)H-Index: 14
Last. Peter Hoskin (University of Manchester)H-Index: 94
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Abstract Background Many muscle invasive bladder cancers are hypoxic which limits efficacy of radiotherapy. Hypoxia modification using carbogen and nicotinamide has been tested in a phase III trial, XXXX. We present mature follow up with biomarker prediction of outcome. Patients and Methods XXXX is a prospective phase III multicentre randomised two arm non-blind clinical trial. Randomisation was to a control arm receiving radical radiotherapy alone or with the addition of carbogen (98% O2, 2% CO...
#1Catharine M L West (MAHSC: Manchester Academic Health Science Centre)H-Index: 77