Linda K. McEvoy
University of California, San Diego
Internal medicinePathologyMagnetic resonance imagingPsychologyNeuroscienceCognitionWorking memoryAlzheimer's Disease Neuroimaging InitiativeDiseaseDementiaAtrophyCognitive declineAlzheimer's diseaseElectroencephalographyAudiologyApolipoprotein EMedicineGerontologyBiologyEpisodic memory
196Publications
66H-index
11.5kCitations
Publications 193
Newest
#1Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 7 authors...
BACKGROUND: Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine. METHODS: A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were fol...
12 CitationsSource
#1Min-Tzu Lo (UCSD: University of California, San Diego)H-Index: 14
#2David A. HindsH-Index: 71
Last. Chi-Hua ChenH-Index: 34
view all 22 authors...
Personality is influenced by genetic and environmental factors1 and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci2, 3, significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132–260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromo...
198 CitationsSource
#1Erin Richard (UCSD: University of California, San Diego)H-Index: 12
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
To better understand the association of alcohol intake with cognitively healthy longevity (CHL), we explored the association between amount and frequency of alcohol intake and CHL among 1,344 older community-dwelling adults. Alcohol intake was assessed by questionnaire in 1984-1987. Cognitive function was assessed in approximate four-year intervals between 1988 and 2009. Multinomial logistic regression, adjusting for multiple lifestyle and health factors, was used to examine the association betw...
15 CitationsSource
#1Toni M. Rush (UCSD: University of California, San Diego)H-Index: 2
#2D. Kritz-Silverstein (UC: University of California)H-Index: 1
Last. Linda K. McEvoy (UC: University of California)H-Index: 66
view all 6 authors...
Objective To examine the association of dietary sodium intake with cognitive function in community-dwelling older adults.
9 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 5 authors...
BACKGROUND: Evidence suggests that moderate alcohol consumption may protect against cognitive decline and dementia. However, uncertainty remains over the patterns of drinking that are most beneficial. OBJECTIVE: To examine associations between amount and frequency of alcohol consumption with multiple domains of cognitive function in a well-characterized cohort of older community-dwelling adults in southern California. DESIGN: Observational, cross-sectional cohort study. SETTING: A research visit...
15 CitationsSource
#1Jennifer S. Yokoyama (UCSF: University of California, San Francisco)H-Index: 29
#2Yunpeng Wang (UCSD: University of California, San Diego)H-Index: 34
Last. Rahul S. Desikan (UCSF: University of California, San Francisco)H-Index: 43
view all 28 authors...
Copyright 2016 American Medical Association. All rights reserved. IMPORTANCE Late-onset Alzheimer disease (AD), the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggests a relationship between inflammation and AD, their relationship is not well understood and could have implications for treatment and prevention strategies. OBJECTIVE To determine whether a subset of genes involved with increased risk of inflammation ar...
95 CitationsSource
#1Jennifer S. Yokoyama (UCSF: University of California, San Francisco)H-Index: 29
#2Yunpeng Wang (UCSD: University of California, San Diego)H-Index: 34
Last. Rahul S. Desikan (UCSF: University of California, San Francisco)H-Index: 43
view all 26 authors...
Objective: We investigated whether a subset of genes involved with increased risk of inflammation are also associated with increased risk for Alzheimer’s disease (AD). Background: Late-onset AD, the most common form of dementia, places a large burden on families and society. Although epidemiological and clinical evidence suggest a relationship between inflammation and AD, it is unclear whether genes associated with inflammation are also involved with Alzheimer’s pathogenesis. Methods: Using summ...
#1Yunpeng Wang (UCSD: University of California, San Diego)H-Index: 34
#2Steffan D. Bos (Oslo University Hospital)H-Index: 26
Last. Ole A. Andreassen (UCSD: University of California, San Diego)H-Index: 123
view all 14 authors...
Background:Epidemiological findings suggest a relationship between multiple sclerosis (MS) and cardiovascular disease (CVD) risk factors, although the nature of this relationship is not well understood.Objective:We used genome-wide association study (GWAS) data to identify shared genetic factors (pleiotropy) between MS and CVD risk factors.Methods:Using summary statistics from a large, recent GWAS (total n > 250,000 individuals), we investigated overlap in single nucleotide polymorphisms (SNPs) ...
15 CitationsSource
#1Christine Fennema-Notestine (UCSD: University of California, San Diego)H-Index: 56
#2Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 12 authors...
White matter disease in the brain increases with age and cardiovascular disease, emerging in midlife, and these associations may be influenced by both genetic and environmental factors. We examined the frequency, distribution, and heritability of abnormal white matter and its association with hypertension in 395 middle-aged male twins (61.9 ± 2.6 years) from the Vietnam Era Twin Study of Aging, 67% of whom were hypertensive. A multi-channel segmentation approach estimated abnormal regions within...
14 CitationsSource
#1John Bellettiere (SDSU: San Diego State University)H-Index: 14
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Elizabeth Barrett-Connor (UCSD: University of California, San Diego)H-Index: 162
view all 6 authors...
Studies linking depressive symptoms and coronary artery calcium (CAC), a measure of subclinical atherosclerosis, have yielded mixed results. No longitudinal studies of depressive symptoms and CAC have included older adults of both genders. This study examined the association of depressive symptoms with CAC and CAC progression in older men and women. Participants were 417 community-dwelling older adults (mean age = 67 ± 7) with no history of heart disease who attended a 1997 to 1999 research clin...
6 CitationsSource