Linda K. McEvoy
University of California, San Diego
Internal medicinePathologyMagnetic resonance imagingPsychologyNeuroscienceCognitionWorking memoryAlzheimer's Disease Neuroimaging InitiativeDiseaseDementiaAtrophyCognitive declineAlzheimer's diseaseElectroencephalographyAudiologyApolipoprotein EMedicineGerontologyBiologyEpisodic memory
196Publications
66H-index
11.5kCitations
Publications 193
Newest
#1Eero VuoksimaaH-Index: 26
#2Linda K. McEvoyH-Index: 66
Last. William S. KremenH-Index: 70
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Source
#1Aree Witoelar (Oslo University Hospital)H-Index: 7
#1Aree Witoelar (Oslo University Hospital)H-Index: 20
Last. Michael E. Weale ('KCL': King's College London)H-Index: 60
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Importance Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an association between immune-mediated diseases and Parkinson disease (PD). The post-GWAS era provides an opportunity for cross-phenotype analyses between different complex phenotypes. Objectives To test the hypothesis that there are common genetic risk variants conveying risk of both PD and autoimmune diseases (ie, pleiotropy) and to identify new shared genetic variants and thei...
106 CitationsSource
#1Emilie T. ReasH-Index: 13
Last. Linda K. McEvoyH-Index: 66
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#1Erin Richard (UCSD: University of California, San Diego)H-Index: 12
#2Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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#1Anna DevorH-Index: 38
#2Ole A. Andreassen (University of Oslo)H-Index: 123
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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© 2017 Macmillan Publishers Limited, part of Springer Nature. The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified hundreds of risk variants potentially implicated in the disease. Further, novel statistical methodology designed for polygenic architecture revealed more potential risk variants. This can provide a link between individual genetic factors and the mechanistic underpinnings of SCZ. Intriguingly, a large number of genes coding for ionotropic and metab...
45 CitationsSource
#1Nathan A. Gillespie (VCU: Virginia Commonwealth University)H-Index: 35
#2Michael C. Neale (VCU: Virginia Commonwealth University)H-Index: 136
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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Author(s): Gillespie, NA; Neale, MC; Jr, HDJ; Eyler, LT; Fennema-Notestine, C; Franz, CE; Lyons, MJ; McEvoy, LK; Dale, AM; Panizzon, MS; Kremen, WS
3 CitationsSource
#1Rahul S. Desikan (UCSF: University of California, San Francisco)H-Index: 43
#2Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
Last. Anders M. Dale (University of California, Berkeley)H-Index: 166
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Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. Methods and findings Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer’s Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10−5). We then i...
182 CitationsSource
#1Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 15
#2Tyler M. Seibert (UCSD: University of California, San Diego)H-Index: 18
Last. Jona A. Hattangadi-Gluth (UCSD: University of California, San Diego)H-Index: 23
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AbstractBackground: Radiation-induced cognitive impairment may be mediated by hippocampal damage, but the structural integrity of this region in tumor patients at baseline is unclear. Hippocampal volumes of 31 glioma patients prior to receiving radiotherapy were compared to a group of 34 healthy controls.Materials and methods: Left and right hippocampi on T1-weighted pre-contrast magnetic resonance images were automatically segmented using Freesurfer, and visually inspected for segmentation erro...
5 CitationsSource
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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Abstract Magnetic resonance imaging (MRI) has become an important tool in the early detection of age-related and neuropathological brain changes. Recent studies suggest that changes in mean diffusivity (MD) of cortical gray matter derived from diffusion MRI scans may be useful in detecting early effects of Alzheimer's disease (AD), and that these changes may be detected earlier than alterations associated with standard structural MRI measures such as cortical thickness. Thus, due to its potentia...
15 CitationsSource
#1Donna Kritz-Silverstein (UCSD: University of California, San Diego)H-Index: 55
#2G A Laughlin (UCSD: University of California, San Diego)H-Index: 4
Last. E. Barrett-ConnorH-Index: 35
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This study examines sex and age differences in associations of systolic and diastolic blood pressure (SBP, DBP), pulse pressure and hypertension with cognitive function in a community-dwelling population.Cross-sectional study.Research clinic visit in 1988-91.Participants were 693 men and 1022 women aged 50-97 Measurements: Blood pressure was measured and 12 cognitive function tests were administered.Average age was 73.8±9.9 in men and 73.2±9.3 in women; 62.6% of men and 63.4% of women were hyper...
7 CitationsSource