Linda K. McEvoy
University of California, San Diego
Internal medicinePathologyMagnetic resonance imagingPsychologyNeuroscienceCognitionWorking memoryAlzheimer's Disease Neuroimaging InitiativeDiseaseDementiaAtrophyCognitive declineAlzheimer's diseaseElectroencephalographyAudiologyApolipoprotein EMedicineGerontologyBiologyEpisodic memory
196Publications
66H-index
11.5kCitations
Publications 193
Newest
#1Graham M.L. Eglit (UCSD: University of California, San Diego)H-Index: 7
#2Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
Last. William S. KremenH-Index: 70
view all 26 authors...
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#1McKenna E. Williams (UCSD: University of California, San Diego)
#1McKenna E. Williams (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 13 authors...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 5 authors...
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#1Makaya Funk‐White (SDSU: San Diego State University)
#2Alison A. Moore (UCSD: University of California, San Diego)H-Index: 36
Last. Christopher N. Kaufmann (UCSD: University of California, San Diego)H-Index: 16
view all 8 authors...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 6 authors...
Abstract Cytoarchitectural brain changes within gray matter and fiber tracts during normal aging remain poorly characterized, and it is unclear whether rates and patterns of brain aging differ by sex. This study used restriction spectrum imaging (RSI) to examine associations between age and brain microstructure in 147 community-dwelling participants (aged 56-99). Widespread associations with older age in multiple diffusion compartments, including increased free water, decreased restricted and hi...
1 CitationsSource
#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 20 authors...
Posttraumatic stress disorder (PTSD) is known to persist, eliciting early medical co-morbidity, and accelerated aging. Although PTSD diagnosis has been found to be associated with smaller volume in multiple brain regions, posttraumatic stress (PTS) symptoms and their associations with brain morphometry are rarely assessed over long periods of time. We predicted that persistent PTS symptoms across ~24 years would be inversely associated with hippocampal, amygdala, anterior cingulate volumes, and ...
6 CitationsSource
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
view all 14 authors...
Sex differences in the manifestations of Alzheimer's disease are under intense investigation. Despite the emerging importance of polygenic predictions for Alzheimer's disease, sex-dependent polygenic effects have not been demonstrated. Here, using a sex crossover analysis, we show that sex-dependent autosomal genetic effects on Alzheimer's disease can be revealed by characterizing disease progress via the hazard function. We first performed sex-stratified genome-wide associations, and then appli...
10 CitationsSource
#1Eero Vuoksimaa (UH: University of Helsinki)H-Index: 26
#2Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 5 authors...
Mild cognitive impairment (MCI) is a heterogeneous condition with variable outcomes. Improving diagnosis to increase the likelihood that MCI reliably reflects prodromal Alzheimer’s Disease (AD) would be of great benefit for clinical practice and intervention trials. In 230 cognitively normal (CN) and 394 MCI individuals from the Alzheimer’s Disease Neuroimaging Initiative, we studied whether an MCI diagnostic requirement of impairment on at least two episodic memory tests improves 3-year predict...
7 CitationsSource
#1Ali Al-Attar (UCSD: University of California, San Diego)H-Index: 16
#2Jaclyn Bergstrom (UCSD: University of California, San Diego)H-Index: 23
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
view all 9 authors...
Background: Hearing impairment is prevalent among older adults and has been identified as a risk factor for cognitive impairment and dementia. We evaluated the association of hearing impairment with long-term cognitive decline among community-dwelling older adults. Methods: A population-based longitudinal study of adults not using hearing aids who had hearing acuity and cognitive function assessed in 1992-96, and were followed for a maximum of 24 years with up to five additional cognitive assess...
20 CitationsSource
#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
view all 10 authors...
BACKGROUND: Although amyloid-beta (Abeta) and microstructural brain changes are both effective biomarkers of Alzheimer's disease, their independent or synergistic effects on cognitive decline are unclear. OBJECTIVE: To examine associations of Abeta and brain microstructure with cognitive decline in amnestic mild cognitive impairment and dementia. METHODS: Restriction spectrum imaging, cerebrospinal fluid Abeta, and longitudinal cognitive data were collected on 23 healthy controls and 13 individu...
1 CitationsSource