Linda K. McEvoy
University of California, San Diego
Internal medicinePathologyMagnetic resonance imagingPsychologyNeuroscienceCognitionWorking memoryAlzheimer's Disease Neuroimaging InitiativeDiseaseDementiaAtrophyCognitive declineAlzheimer's diseaseElectroencephalographyAudiologyApolipoprotein EMedicineGerontologyBiologyEpisodic memory
196Publications
66H-index
11.5kCitations
Publications 193
Newest
#1Sarah J. Banks (UCSD: University of California, San Diego)H-Index: 21
#2Murray J. Andrews (UCSD: University of California, San Diego)H-Index: 2
Last. James B. Brewer (UCSD: University of California, San Diego)H-Index: 50
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Abstract null null To determine if sex differences in verbal memory in AD are related to differences in extent or distribution of pathological tau, we studied 275 participants who were amyloid PET positive and carried clinical classifications of normal cognition, mild cognitive impairment (MCI) or dementia, and had tau (AV1451) PET. We compared tau distribution between men and women, and as a function of genetic risk. In MCI we further explored the relationship between quantity and distribution ...
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Sex differences have been observed in the clinical manifestations of Alzheimer's disease (AD) and elucidating their genetic basis is an active research topic. Based on autosomal genotype data of 7,216 men and 10,680 women, including 8,136 AD cases and 9,760 controls, we explored sex-related genetic heterogeneity in AD by investigating SNP heritability, genetic correlation, as well as SNP- and gene-based genome-wide analyses. We found similar SNP heritability (men: 19.5%; women: 21.5%) and high g...
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#1Erin Richard (UCSD: University of California, San Diego)H-Index: 12
#2Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
Last. Rany M. Salem (UCSD: University of California, San Diego)H-Index: 38
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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Midlife vascular disease increases risk for dementia and effects of vascular dysfunction on brain health differ between men and women. Elevated pulse pressure, a surrogate for arterial stiffness, contributes to cerebrovascular pathology and white matter damage that may advance cognitive aging; however, it remains unclear how associations between pulse pressure and neural integrity differ by sex and age. This study used restriction spectrum imaging to examine associations between pulse pressure a...
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#1Mark Sanderson-Cimino (UCSD: University of California, San Diego)H-Index: 6
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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Objective: Abnormal white matter (AWM) on magnetic resonance imaging is associated with cognitive performance in older adults. We explored cognitive associations with AWM during late-midlife. Method: Participants were community-dwelling men (n = 242; M = 61.90 years; range = 56-66). Linear-mixed effects regression models examined associations of total, periventricular, and deep AWM with cognitive performance, controlling for multiple comparisons. Models considering specific cognitive domains con...
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#1Jonathan Davitte (UCSD: University of California, San Diego)
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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We examined the association between dietary potassium intake and all-cause and cause-specific mortality among community-dwelling older adults. Potassium intake was assessed with a food frequency questionnaire administered to 1,363 older adults (mean age 71.0 ± 10.6 years). Cox proportional hazard regressions estimated hazard ratios for sex-specific quintiles of calorie-adjusted potassium in relation to all-cause and cause-specific (cardiovascular disease, CVD, and stroke) mortality, adjusting fo...
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#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Olivia K. Puckett (UCSD: University of California, San Diego)H-Index: 1
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
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INTRODUCTION The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the sleep-wake cycle, modulating cognitive function, and AD progression. METHODS Participants were 481 men (ages 62 to 71.7) from the Vietnam Era Twin Study of Aging. LC structural integrity was indexed by neuromelanin-sensitive magnetic resonance imaging (MRI) contrast-to-noise ratio (LCCNR ). We examined LCCNR , cognition, amnestic mild cognitive imp...
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#1Emilie T. Reas (UCSD: University of California, San Diego)H-Index: 13
#2Donald J. Hagler (UCSD: University of California, San Diego)H-Index: 88
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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Normal brain aging is characterized by declining neuronal integrity, yet it remains unclear how microstructural injury influences cognitive aging and whether such mechanisms differ between sexes. Using restriction spectrum imaging (RSI), we examined sex differences in associations between brain microstructure and cognitive function in 147 community-dwelling older men and women (56-99 years). Gray and white matter microstructure correlated with global cognition, executive function, visuospatial m...
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#1Humberto Parada (SDSU: San Diego State University)H-Index: 17
#2Gail A. Laughlin (UCSD: University of California, San Diego)H-Index: 65
Last. Linda K. McEvoy (UCSD: University of California, San Diego)H-Index: 66
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BACKGROUND We examined the associations between dual impairments in visual and hearing acuity and aging-related cognitive decline. METHODS This was a longitudinal study of adults who had visual and hearing acuity and cognitive function assessed in 1992-1996 and were followed for up to 24 years (mean = 7.3 years), with up to five additional cognitive assessments. Visual impairment was defined as vision worse than 20/40, hearing impairment as pure-tone average thresholds >25 dB. Associations were ...
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#1Riki E Slayday (SDSU: San Diego State University)
#2Daniel E. Gustavson (UCSD: University of California, San Diego)H-Index: 16
Last. Carol E. Franz (UCSD: University of California, San Diego)H-Index: 48
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OBJECTIVE Heavy alcohol consumption is associated with poorer cognitive function in older adults. Although understudied in middle-aged adults, the relationship between alcohol and cognition may also be influenced by genetics such as the apolipoprotein (ApoE) e4 allele, a risk factor for Alzheimer's disease. We examined the relationship between alcohol consumption, ApoE genotype, and cognition in middle-aged adults and hypothesized that light and/or moderate drinkers (≤2 drinks per day) would sho...
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