Cynthia H. McCollough
Mayo Clinic
Imaging phantomOpticsPhysicsRadiologyIterative reconstructionArtificial intelligenceTomographyMaterials scienceMedical physicsImage resolutionScannerRadiation doseNuclear medicineMedical imagingImage noiseComputer scienceComputed tomographyImage qualityMedicineDetector
507Publications
76H-index
14.2kCitations
Publications 490
Newest
#1Dane KlettH-Index: 9
#2Aaron M. PotretzkeH-Index: 13
Last. Cynthia H. McColloughH-Index: 76
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#1Hao Gong (Mayo Clinic)H-Index: 8
#2Liqiang Ren (Mayo Clinic)H-Index: 8
Last. Lifeng Yu (Mayo Clinic)H-Index: 48
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OBJECTIVE In x-ray Computed Tomography (CT), many important clinical applications may benefit from a fast acquisition speed. Helical scan is the most widely used acquisition mode in clinical CT, where a fast helical pitch can improve the acquisition speed. However, on a typical single-source CT (SSCT) system, the helical pitch p typically cannot exceed 1.5; otherwise, reconstruction artifacts will result from data insufficiency. The purpose of this work is to develop a deep convolutional neural ...
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#1Liqiang Ren (Mayo Clinic)H-Index: 8
#2Nathan R. HuberH-Index: 2
Last. Lifeng YuH-Index: 48
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PURPOSE The aims of this study were to develop a single-scan dual-contrast protocol for biphasic liver imaging with 2 intravenous contrast agents (iodine and gadolinium) and to evaluate its effectiveness in an exploratory swine study using a photon-counting detector computed tomography (PCD-CT) system. MATERIALS AND METHODS A dual-contrast CT protocol was developed for PCD-CT to simultaneously acquire 2 phases of liver contrast enhancement, with the late arterial phase enhanced by 1 contrast age...
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#1Hao Gong (Mayo Clinic)H-Index: 8
#2Lifeng YuH-Index: 48
Last. Cynthia H. McColloughH-Index: 76
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OBJECTIVE To investigate reader performance as a function of patient size for the detection of hepatic metastases when an automatic exposure control (AEC) system is used, which varies image noise as a function of patient size. METHODS Abdominal computed tomograhy examinations across 100, 120, 160, and 200 quality reference tube current-time product were collected, involving a cohort of 83 patients. Three radiologists identified hepatic metastases across all dose levels. Partial Spearman rank cor...
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#1Liqiang Ren (Mayo Clinic)H-Index: 8
#2Thomas Allmendinger (Siemens)H-Index: 19
Last. Lifeng Yu (Mayo Clinic)H-Index: 48
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Purpose Multi-energy CT (MECT) has a great potential to enable many novel clinical applications such as simultaneous multi-contrast imaging. The purpose of this study was to implement triple-beam MECT on traditional energy-integrating-detector (EID) CT platform (EID-MECT). Methods This was accomplished by mounting a z-axis split-filter (0.05 mm Au, 0.6 mm Sn) on Tube A of a dual-source EID CT scanner. With the two split x-ray beams from Tube A and the third beam from Tube B, three beams with dif...
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#1Hao Gong (Mayo Clinic)H-Index: 8
#2Shengzhen Tao (Mayo Clinic)H-Index: 13
Last. Shuai Leng (Mayo Clinic)H-Index: 53
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Mega-voltage fan-beam Computed Tomography (MV-FBCT) holds potential in accurate determination of relative electron density (RED) and proton stopping power ratio (SPR) but is not widely available. To demonstrate the feasibility of MV-FBCT using a medical linear accelerator (LINAC) with a 2.5 MV imaging beam, an electronic portal imaging device (EPID) and multileaf collimators (MLCs). MLCs were used to collimate MV beam along z direction to enable a 1 cm width fan-beam. Projection data were acquir...
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#1Payam Mohammadinejad (Mayo Clinic)H-Index: 1
#2Lukasz Kwapisz (Mayo Clinic)H-Index: 1
Last. Yong S. Lee (Mayo Clinic)H-Index: 2
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BackgroundDue to their easy accessibility, CT scans have been increasingly used for investigation of gastrointestinal (GI) bleeding.PurposeTo estimate the performance of a dual-phase, dual-energy (...
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#1Cynthia H. McCollough (Mayo Clinic)H-Index: 76
#2David W. Jordan (University Hospitals of Cleveland)H-Index: 15
Last. Lawrence T. Dauer (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 28
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#1Kishore Rajendran (Mayo Clinic)H-Index: 11
#2Martin Petersilka (Siemens)H-Index: 9
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
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We report a comprehensive evaluation of a full field-of-view (FOV) photon-counting detector (PCD) CT system using phantoms, and qualitatively assess image quality in patient examples. A whole-body PCD-CT system with 50 cm FOV, 5.76 cm z-detector coverage and two acquisition modes (standard: 144 × 0.4 mm collimation and ultra-high resolution, UHR: 120 × 0.2 mm collimation) was used in this study. Phantom scans were acquired to assess image uniformity, CT number accuracy, noise power spectrum, spa...
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#1Scott S. Hsieh (Mayo Clinic)H-Index: 1
#1Scott S. HsiehH-Index: 1
Last. Cynthia H. McCollough (Mayo Clinic)H-Index: 76
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The use of a photon counting detector in CT (PCD CT) is currently the subject of intense investigation and development. In this review article, we will describe potential clinical applications of this technology with a particular focus on the experience of our own institution with a prototype PCD CT scanner. PCDs have three primary advantages over conventional, energy integrating detectors (EIDs): they provide spectral information without need for a dedicated dual energy protocol; they are immun...
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