Constance L. Chik
University of Alberta
PhosphorylationInternal medicineEndocrinologyMolecular biologyReceptorKinaseChemistryProtein kinase CPinealocyteStimulationCyclic nucleotideDiabetes mellitusMAPK/ERK pathwayPhosphodiesterase 3Signal transductionMedicinePDE10AIntracellularBiologyActivator (genetics)Cell biologyProtein kinase A
112Publications
28H-index
2,212Citations
Publications 113
Newest
#1Tae Nakano-Tateno (U of A: University of Alberta)H-Index: 4
#2Motoyasu Satou (U of A: University of Alberta)H-Index: 2
Last. Constance L. Chik (U of A: University of Alberta)H-Index: 28
view all 8 authors...
Corticotroph carcinomas and aggressive corticotroph tumors can be resistant to conventional therapy, including surgery, radiotherapy, and medical treatment. Recent evidence suggests that temozolomide (an oral alkylating agent) administered with capecitabine (pro-drug of 5-fluorouracil) may improve progression-free survival in patients with high-risk corticotroph tumors and carcinomas. This led to the use of capecitabine and temozolomide (CAPTEM) in two patients, one with a corticotroph carcinoma...
Source
#1Sylvia Roschkov (U of A: University of Alberta)H-Index: 1
#2Constance L. Chik (U of A: University of Alberta)H-Index: 28
Abstract Objectives In this study, we evaluated the feasibility of a nurse practitioner-led outpatient clinic (NPC) to facilitate the safe transition of diabetes patients receiving insulin therapy between hospital and the community. Methods An NPC was set up to manage patients who had diabetes education in hospital and discharged on insulin. In addition to patient demographics and admission diagnosis, days seen postdischarge, duration of follow up, diabetes interventions and discharge care plan ...
Source
#1Cyndy Liu (U of A: University of Alberta)
#2Tae Nakano-Tateno (U of A: University of Alberta)H-Index: 4
Last. Toru Tateno (U of A: University of Alberta)H-Index: 15
view all 5 authors...
Pituitary adenomas are benign tumours that can cause an individual various clinical manifestations including tumour mass effects and/or the diverse effects of abnormal pituitary hormone secretion. Given the morbidity and limited treatment options for pituitary adenomas, there is a need for better biomarkers and treatment options. One molecule that is of specific interest is the signal transducer and activator of transcription 3 (STAT3), a transcription factor that plays a critical role in mediat...
Source
#1Jason Wang (U of A: University of Alberta)H-Index: 1
#2Motoyasu Satou (Dokkyo Medical University)H-Index: 8
Last. Toru Tateno (U of A: University of Alberta)H-Index: 15
view all 10 authors...
Source
#3Jacob C. Easaw (U of A: University of Alberta)H-Index: 15
The papillary subtype of craniopharyngioma (CP) rarely occurs in children and commonly presents as a suprasellar lesion. Patients with papillary CPs frequently harbor the BRAF-V600E mutation, and treatment with a BRAF inhibitor results in tumor shrinkage in several patients. Herein, we report a patient with childhood-onset papillary CP treated with vemurafenib for 40 months after multiple surgeries. At age 10, he presented with growth failure secondary to an intrasellar cystic lesion. He had 3 t...
Source
#1Motoyasu Satou (U of A: University of Alberta)H-Index: 2
#2Jason Wang (U of A: University of Alberta)H-Index: 1
Last. Toru Tateno (U of A: University of Alberta)H-Index: 15
view all 12 authors...
Abstract Pituitary tumors (PTs) can cause significant mortality and morbidity due to limited therapeutic options. L-type amino acid transporters (LATs), in particular, the LAT1 isoform, is expressed in a variety of tumor cells. Pharmacological inhibition or genetic ablation of LAT1 can suppress leucine transport into cancer cells, resulting in suppression of cancer cell growth. However, roles of LAT1 in PTs have not been elucidated. Therefore, we assessed LAT1 expression in PTs and evaluated a L...
Source
#1Motoyasu Sato (U of A: University of Alberta)
#2Jason Wang (U of A: University of Alberta)H-Index: 1
Last. Toru Tateno (U of A: University of Alberta)H-Index: 15
view all 7 authors...
Source
#1Tae Tateno (U of A: University of Alberta)
#2Toru Tateno (U of A: University of Alberta)H-Index: 15
Last. Constance L. Chik (U of A: University of Alberta)H-Index: 28
view all 3 authors...
Source
#1Mariam Shahidi (U of A: University of Alberta)H-Index: 2
#2Richard A. Phillips (UBC: University of British Columbia)H-Index: 2
Last. Constance L. Chik (U of A: University of Alberta)H-Index: 28
view all 3 authors...
Previous studies have linked systemic glucocorticoid use with intestinal perforation. However, the association between intestinal perforation and endogenous hypercortisolism has not been well described, with only 14 previously published case reports. In this study, we investigated if intestinal perforation occurred more frequently in patients with ectopic ACTH syndrome and in those with a greater than 10-fold elevation of 24-hour urinary free cortisol level. Of 110 patients with ACTH-dependent C...
Source
#1Sylvia L. Asa (Princess Margaret Cancer Centre)H-Index: 114
#2Shereen Ezzat (Princess Margaret Cancer Centre)H-Index: 42
Last. Ozgur MeteH-Index: 37
view all 12 authors...
: Tumors of hypothalamic neurons that produce vasopressin are rare. We retrieved all cases of vasopressin-positive tumors in the sellar region from the database of the Department of Pathology. Five cases fulfilled the selection criteria, representing the first series of such tumors. Clinical, radiologic, and pathologic features were reviewed. Four tumors classified as neurocytomas were identified in 3 females and 1 male patient; the ages at onset of symptoms ranged from 17 to 40 years. All were ...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.