Wen-Yih Isaac Tseng
National Taiwan University
Internal medicineMagnetic resonance imagingDiffusion MRIArtificial intelligencePsychologyCardiologyNeuroscienceCognitionCorpus callosumAutism spectrum disorderFunctional magnetic resonance imagingAttention deficit hyperactivity disorderWhite matterDiffusion Spectrum ImagingNuclear medicineIn patientMathematicsNuclear magnetic resonanceAudiologyMedicineTractographyFractional anisotropy
Publications 200
#1Huey-Ling Chiang (NTU: National Taiwan University)H-Index: 15
#2Hsiang-Yuan Lin (U of T: University of Toronto)H-Index: 2
Last. Susan Shur-Fen Gau (NTU: National Taiwan University)H-Index: 61
view all 0 authors...
Background/purpose null Increased intra-individual variability (IIV) in reaction time (RT) is a key feature of attention-deficit/hyperactivity disorder (ADHD). However, little is known about neurobiology underpinnings of IIV in ADHD. null null null Methods null We assessed 55 youths with ADHD, and 55 individually-matched typically developing control (TDC) with the MRI and Conners' Continuous Performance Test. The ex-Gaussian distribution of RT was estimated to capture IIV with the parameters σ (...
#1Chiu S (NTU: National Taiwan University)
#2Wen-Yih Isaac Tseng (NTU: National Taiwan University)H-Index: 49
Last. Wei A
view all 3 authors...
Mitochondria are semi-autonomous eukaryotic organelles, that participate in energy production and metabolism, making mitochondrial quality control crucial. As most mitochondrial proteins are encoded by nuclear genes, quality control depends on proper mitochondria-nucleus communication, designated mitochondrial retrograde signaling. Early studies focused on retrograde signaling participants and specific gene knockouts. However, mitochondrial signal modulation remains elusive. Using yeast, we simu...
#1Yu-Hung Tung (NTU: National Taiwan University)H-Index: 1
#2Hsiang-Yuan Lin (NTU: National Taiwan University)H-Index: 13
Last. Susan Shur-Fen GauH-Index: 61
view all 8 authors...
Objective:The heterogeneity of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) preclude definitive identification of neurobiomarkers and biological risks. High cl...
#2Ruei-Yi Chao (NTU: National Taiwan University)
Last. Wen-Yih Isaac TsengH-Index: 49
view all 5 authors...
Abstract Decreased awareness of memory declines in mild cognitive impairment (MCI) has been linked to structural or functional changes in a wide gray matter network; however, the underlying white matter pathway correlations for the memory awareness deficits remain unknown. Moreover, consistent findings have not been obtained regarding the cognitive basis of disturbed awareness of memory declines in MCI. Due to the methodological drawbacks (e.g., correlational analysis without controlling confoun...
#1Meng-Tien Wu (NTU: National Taiwan University)H-Index: 2
#2Pei-Fang TangH-Index: 22
Last. Ching Lan (NTU: National Taiwan University)H-Index: 1
view all 10 authors...
Tai Chi Chuan (TCC) exercise has been shown to improve cognitive task-switching performance in older adults, but the extent of this positive effect varies among individuals. Past research also shows that brain white matter (white matter) integrity could predict behavioral gains of cognitive and motor learning. Therefore, in this randomized controlled trial (NCT02270320), we examined whether baseline integrity of three target white matter tract groups was predictive of task-switching improvement ...
#1Wen-Yih Isaac Tseng (NTU: National Taiwan University)H-Index: 49
#2Yung-Chin HsuH-Index: 8
Last. Gordon D. WaiterH-Index: 28
view all 7 authors...
White matter fiber tracts demonstrate heterogeneous vulnerabilities to aging effects. Here, we estimated age-related differences in tract properties using UK Biobank diffusion magnetic resonance imaging data of 7167 47- to 76-year-old neurologically healthy people (3368 men and 3799 women). Tract properties in terms of generalized fractional anisotropy, axial diffusivity, radial diffusivity, and mean diffusivity were sampled on 76 fiber tracts; for each tract, age-related differences were estima...
3 CitationsSource
#1Tz‐Yun Jan (NTU: National Taiwan University)H-Index: 1
#1Tz-Yun Jan (NTU: National Taiwan University)
Last. Wang-Tso Lee (NTU: National Taiwan University)H-Index: 28
view all 8 authors...
Individuals with Rett syndrome (RTT) commonly demonstrate Parkinsonian features and dystonia at teen age; however, the pathological reason remains unclear. Abnormal iron accumulation in deep gray matter were reported in some Parkinsonian-related disorders. In this study, we investigated the iron accumulation in deep gray matter of RTT and its correlation with dystonia severity. We recruited 18 RTT-diagnosed participants with MECP2 mutations, from age 4 to 28, and 28 age-gender matched controls a...
#1Yao-Chia Shih (NTU: National Taiwan University)H-Index: 4
#2Fa-Hsuan Lin (U of T: University of Toronto)H-Index: 31
view all 4 authors...
BACKGROUND Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is a common intractable epilepsy. To seek neural correlates of seizure recurrence, this study investigated aberrant intrinsic effective connectivity (iEC) in TLE with unilateral MTS and their associations with seizure frequency. METHODS Thirty patients with unilateral MTS (left/right MTS = 14/16) and 37 age-matched healthy controls underwent resting-state functional magnetic resonance imaging (rsfMRI) on a 3-Tesla magne...
#1Hsiang-Yuan Lin (NTU: National Taiwan University)H-Index: 13
#2Daniel Kessler (UM: University of Michigan)H-Index: 16
Last. Susan Shur-Fen Gau (NTU: National Taiwan University)H-Index: 61
view all 4 authors...
Abstract Objective While there are frequent reports of shared neurofunctional and neurostructural alterations among probands with attention-deficit/hyperactivity disorder (ADHD) and their unaffected siblings, there is little knowledge regarding whether abnormalities in the resting-state functional connectivity of ADHD probands is also expressed in unaffected siblings, or if this unaffected (but at-risk) cohort manifests distinct patterns. Method We used a multivariate connectome-wide association...
2 CitationsSource
#1Pin-Yu Chen (NTU: National Taiwan University)H-Index: 32
#2Chang-Le Chen (NTU: National Taiwan University)H-Index: 3
Last. Wen-Yih Isaac Tseng (NTU: National Taiwan University)H-Index: 49
view all 6 authors...