Shengtao Zhou
Sichuan University
CancerInternal medicineEndocrinologyCellApoptosisIn vivoTumor microenvironmentMetastasisAngiogenesisOvarian cancerOncogeneProteomicsCancer researchCarcinogenesisCell growthComputational biologyMedicineBiologyCell biologyCancer cell
64Publications
23H-index
1,233Citations
Publications 63
Newest
#1Zhengnan Yang (Sichuan University)H-Index: 3
#2Ryan C. Gimple (UCSD: University of California, San Diego)H-Index: 17
Last. Shengtao Zhou (Sichuan University)H-Index: 23
view all 6 authors...
Nuclear receptors are a family of transcription factors localized in cell nuclei, sensing specific ligands and fine-tuning a variety of cell physiological events. They have been intensively investigated in cancer biology. With their excellent properties of druggability and actionability, nuclear receptors have demonstrated much promise as novel therapeutic targets for different cancer types. Accumulating evidence has highlighted the essential roles of certain nuclear receptors in tumor immunolog...
1 CitationsSource
#1Young Ha Ahn (Sichuan University)
#1Young Ha Ahn (Sichuan University)H-Index: 2
Last. Tae-Don Kim (Korea Research Institute of Bioscience and Biotechnology)H-Index: 27
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Tryptophanyl-tRNA synthetase (WRS) is an essential enzyme that catalyzes the ligation of tryptophan (Trp) to its cognate tRNAtrp during translation via aminoacylation. Interestingly, WRS also plays physiopathological roles in diseases including sepsis, cancer, and autoimmune and brain diseases and has potential as a pharmacological target and therapeutic. However, WRS is still generally regarded simply as an enzyme that produces Trp in polypeptides; therefore, studies of the pharmacological effe...
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#1Zhengnan Yang (Sichuan University)H-Index: 3
#2Wei WangH-Index: 84
Last. Shengtao Zhou (Sichuan University)H-Index: 23
view all 9 authors...
Ovarian cancer represents a highly lethal disease that poses a substantial burden for females, with four main molecular subtypes carrying distinct clinical outcomes. Here, we demonstrated that plasma cells, a subset of antibody-producing B cells, were enriched in the mesenchymal subtype of high-grade serous ovarian cancers (HGSCs). Plasma cell abundance correlated with the density of mesenchymal cells in clinical specimens of HGSCs. Coculture of nonmesenchymal ovarian cancer cells and plasma cel...
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#1Jingyao Chen (Sichuan University)H-Index: 1
#2Lei Zhao (Sichuan University)H-Index: 1
Last. Feifei Na (Sichuan University)H-Index: 1
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Tumor organoids recapitulate pathological properties and would serve as an excellent ex vivo model for drug discovery. Here, we performed an unbiased drug screening on drivers-defined tumor organoids from mouse endometrial cancer, the most prevalent gynecological malignancy in human, with a small molecule library targeting epigenetic factors. Among them, menin-MLL inhibitors MI-136 and MI-463 scored. The therapeutic capacity of MI-136 was further validated in tumor organoids in vitro and an orth...
2 CitationsSource
#1Xiaofei Wang (Sichuan University)H-Index: 1
#2Ran Zhou (Sichuan University)H-Index: 1
Last. Yuan Wang (Sichuan University)H-Index: 11
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Glioblastoma (GBM) is an incurable and highly heterogeneous brain tumor, originating from human neural stem/progenitor cells (hNSCs/hNPCs) years ahead of diagnosis. Despite extensive efforts to characterize hNSCs and end-stage GBM at bulk and single-cell levels, the de novo gliomagenic path from hNSCs is largely unknown due to technical difficulties in early-stage sampling and preclinical modeling. Here, we established two highly penetrant hNSC-derived malignant glioma models, which resemble the...
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#1Shengtao Zhou (Sichuan University)H-Index: 23
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#1Franz RödelH-Index: 55
#2Shengtao Zhou (Sichuan University)H-Index: 23
Last. Klaus Strebhardt (DKFZ: German Cancer Research Center)H-Index: 60
view all 9 authors...
Since type and duration of an appropriate adjuvant chemotherapy in early-stage ovarian cancer (OC) are still being debated, novel markers for a better stratification of these patients are of utmost importance for the design of an improved chemotherapeutical strategy. In contrast to numerous cancer studies on cellular proliferation based on the immunohistochemistry-driven evaluation of protein expression, we compared mRNA and protein expression of two independent markers of cellular proliferation...
4 CitationsSource
#1Shuang Huang (Sichuan University)H-Index: 4
#2Nianxin Zhou (Sichuan University)H-Index: 4
Last. Shengtao Zhou (Sichuan University)H-Index: 23
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SUMMARY The emerging immune checkpoint blockade (ICB) therapy has ushered the cancer therapeutics field into an era of immunotherapy. While ICB treatment provides remarkable clinical responses in a subset of cancer patients, this regimen fails to extend survival in a large proportion of patients. Here, we found that a combined treatment of estrogen receptor beta (ERβ) agonist and PD-1 antibody treatment improved therapeutic efficacy in mouse tumor models, compared with monotherapies, by reducing...
4 CitationsSource
#1Lian Xu (Sichuan University)H-Index: 8
#2Ryan C. Gimple (UCSD: University of California, San Diego)H-Index: 17
Last. Shengtao Zhou (Sichuan University)H-Index: 23
view all 13 authors...
Exosomes are critical intercellular messengers released upon the fusion of multivesicular bodies with the cellular plasma membrane that deliver their cargo in the form of extracellular vesicles. Containing numerous nonrandomly packed functional proteins, lipids, and RNAs, exosomes are vital intercellular messengers that contribute to the physiologic processes of the healthy organism. During the post-genome era, exosome-oriented proteomics have garnered great interest. Since its establishment, ma...
1 CitationsSource
#1Shengtao Zhou (Sichuan University)H-Index: 23
#2Linjie Zhao (Sichuan University)H-Index: 15
Last. Xia Zhao (Sichuan University)H-Index: 58
view all 5 authors...
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