Yosuke Shimazu
Okayama University
GeneGenetic enhancementSurgeryPathologyVascular endothelial growth factor ACellGene expressionMolecular biologyIntegrinAdverse effectImmunologyGlioblastomaVascular endothelial growth factorBevacizumabGliomaCilengitideAngiogenesisPlatelet-derived growth factorAnnexin A2Viral vectorCancer researchMedicineBiologyPharmacology
24Publications
6H-index
94Citations
Publications 24
Newest
#1Yusuke Tomita (Okayama University)H-Index: 6
#2Yosuke Shimazu (Okayama University)H-Index: 6
Last. Isao Date (Okayama University)H-Index: 58
view all 12 authors...
Ventriculitis is a rare, serious complication of neurosurgery. A 59-year-old man who had undergone a craniotomy for a paranasal adenocarcinoma, developed a right frontal cystic lesion. We performed a bifrontal craniotomy to remove the lesion. The dura was repaired with non-vascularized free fascia lata in watertight fashion. Ventriculitis occurred 3 days postoperatively. Ventricular drainage, craniectomy, and endoscopic irrigation were undertaken to remove an abscess. The dura and the resection ...
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#1Yasuhiko HattoriH-Index: 5
Last. Yosuke ShimazuH-Index: 6
view all 13 authors...
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#1Atsuhito Uneda (Okayama University)H-Index: 8
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 15 authors...
Glioblastoma (GBM) is the most lethal primary brain tumor characterized by significant cellular heterogeneity, namely tumor cells, including GBM stem-like cells (GSCs) and differentiated GBM cells (DGCs), and non-tumor cells such as endothelial cells, vascular pericytes, macrophages, and other types of immune cells. GSCs are essential to drive tumor progression, whereas the biological roles of DGCs are largely unknown. In this study, we focused on the roles of DGCs in the tumor microenvironment....
2 CitationsSource
#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Masahiro Kameda (Okayama University)H-Index: 21
Last. Isao Date (Okayama University)H-Index: 58
view all 6 authors...
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#1Yusuke TomitaH-Index: 6
#2Kazuhiko KurozumiH-Index: 23
Last. Isao DateH-Index: 58
view all 5 authors...
Breast cancer is the most common malignancy among women worldwide, and the main cause of death in patients with breast cancer is metastasis. Metastasis to the central nervous system occurs in 10% to 16% of patients with metastatic breast cancer, and this rate has increased because of recent advancements in systemic chemotherapy. Because of the various treatments available for brain metastasis, accurate diagnosis and evaluation for treatment are important. Magnetic resonance imaging (MRI) is one ...
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#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Kentaro Fujii (Okayama University)H-Index: 8
Last. Isao Date (Okayama University)H-Index: 58
view all 10 authors...
Malignant glioma is one of the most common brain cancers in humans, which is very devastating. The expression of reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) is decreased in various human cancers. Lately, we have developed a novel second-generation adenoviral vector that expresses REIC/Dkk-3 (Ad-SGE-REIC) and revealed its antiglioma efficacy. The present investigator-initiated clinical trial is a single-arm, prospective, nonrandomized, noncomparative, open-label, single-cente...
2 CitationsSource
#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2K. Fujii (Okayama University)H-Index: 2
Last. Isao Date (Okayama University)H-Index: 58
view all 11 authors...
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#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu IchikawaH-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 14 authors...
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#1Yosuke Shimazu (Okayama University)H-Index: 6
#2Agila Somasundaram (Children's Memorial Hospital)
Last. Oren J. Becher (NU: Northwestern University)H-Index: 28
view all 4 authors...
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#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Kentaro Fujii (Okayama University)H-Index: 8
Last. Isao Date (Okayama University)H-Index: 58
view all 14 authors...
INTRODUCTION Expression of the gene encoding reduced expression in immortalized cells/Dickkopf-3 (REIC/Dkk-3) was reported to be reduced in a variety of human cancer cells. We previously examined the antitumor effect of an adenoviral vector carrying REIC/Dkk-3 gene (Ad-CAG-REIC). Recently, a novel adenoviral vector expressing REIC/Dkk-3 has also been developed based on the cytomegalovirus promoter-driven super gene expression system (Ad-SGE-REIC). We evaluated the anti-glioma effect of the Ad-SG...
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