Jihyun Um
Kyung Hee University
Downregulation and upregulationEndocrinologySurgeryStromal cellChemistryExtracellular matrixApoptosisSubstance PVascular endothelial growth factorDermal fibroblastNeovascularizationWound healingAngiogenesisType 1 diabetesStem cellPopulationCancer researchDiabetes mellitusMedicineBiology
9Publications
6H-index
81Citations
Publications 9
Newest
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Nunggum Jung (Kyung Hee University)H-Index: 4
Last. Ki-Sook ParkH-Index: 18
view all 7 authors...
Abstract Preservation of pancreatic β-cells is required for the development of therapies for type 1 and type 2 diabetes (T1D and T2D, respectively). Our previous study demonstrated that substance P (SP) preserves β-cell populations in mice with streptozotocin-induced T1D. Here, we demonstrated that chronic systemic treatment with SP restored the mass of β-cells both in nonobese diabetic (NOD) mice with T1D or db/db mice with T2D. SP delayed the onset of T1D in NOD mice via immune modulation. SP ...
3 CitationsSource
#1Nunggum Jung (Kyung Hee University)H-Index: 4
#2Jihyun Um (Kyung Hee University)H-Index: 6
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 8 authors...
Abstract Preservation of the pancreatic β-cell population is required for the development of therapies for diabetes, which is caused by a decrease in β-cells. Here, we demonstrate the antidiabetic effects of substance P (SP) in type 1 diabetes (T1D) mice induced with streptozotocin. SP enhanced the compensatory proliferation of β-cells in order to restore β-cells in response to acute injury induced by a single high-dose of streptozotocin. However, SP affected neither the basal proliferation of β...
5 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 3 authors...
: Wound healing is delayed in diabetes due to a number of factors, including impaired angiogenesis and poor dermal healing. The present study demonstrated that subcutaneous administration of substance P (SP) accelerates wound healing in db/db type 2 diabetic mice (db/db mice). SP injection (10 nM/kg, subcutaneously) enhanced angiogenesis, induced the mobilization of endothelial progenitor cells (EPCs) and increased the number of EPC‑colony forming units (EPC‑CFUs) in the bone marrow of db/db mic...
13 CitationsSource
#1Jinyeong Yu (Kyung Hee University)H-Index: 5
#2Sanghyuk Choi (Kyung Hee University)H-Index: 3
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 4 authors...
Dermal fibroblasts play essential roles in wound healing and their dysfunction has been shown to be associated with impaired wound healing in diabetes. In the present study, we aimed at investigating whether Yes-associated protein (YAP), a mediator of mechanotransduction in dermal fibroblasts, is associated with impaired wound healing in diabetic mice. Compared with that in the control, the rate of wound contraction was decreased twofold in db/db type 2 diabetic mice (db/db mice). To mimic diabe...
2 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 4 authors...
Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP). Our study shows that systemic co-treatment of SP and thiorphan, an inhibitor of NEP synergically increased the number of α-smooth muscle actin positive-blood vessels in skin wounds. However, there was no...
11 CitationsSource
#1Nunggum Jung (Kyung Hee University)H-Index: 4
#2Jinyeong Yu (Kyung Hee University)H-Index: 5
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 5 authors...
Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance P (SP) rescues the malfunctions of dermal fibroblasts in diabetes. SP increased the proliferation of diabetic dermal fibroblasts dose-dependently, although the effect was lower compared to the SP-stimulated proliferation of normal dermal fibroblasts. In contrast to normal dermal fibrob...
4 CitationsSource
#1Jihyun Um (Kyung Hee University)H-Index: 6
#2Nunggum Jung (Kyung Hee University)H-Index: 4
Last. Ki-Sook Park (Kyung Hee University)H-Index: 18
view all 6 authors...
Wound healing is essential for the survival and tissue homeostasis of unicellular and multicellular organisms. The current study demonstrated that the neuropeptide substance P (SP) accelerated the wound healing process, particularly in the skin. Subcutaneous treatment of SP accelerated wound closing, increased the population of α-smooth muscle actin positive myofibroblasts, and increased extracellular matrix deposition at the wound site. Moreover, SP treatment enhances angiogenesis without a loc...
16 CitationsSource
#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Suna Kim (Kyung Hee University)H-Index: 7
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 6 authors...
Retinal degeneration is caused by neovascularization and persistent inflammation in the retinal pigment epithelium (RPE) and choroid, and causes serious eye disease including age-related macular degeneration (AMD). Thus, inhibiting inflammation and neovascularization may be a primary approach to protect the retina from degeneration. The purpose of this study was to determine whether substance P (SP), which can suppress inflammation and mobilize stem cells, can protect the RPE from degeneration. ...
13 CitationsSource
#1Hyun Sook Hong (Kyung Hee University)H-Index: 11
#2Jihyun Um (Kyung Hee University)H-Index: 6
Last. Youngsook Son (Kyung Hee University)H-Index: 23
view all 4 authors...
Steroids are treated for most inflammatory diseases but cause serious side effects such as diabetes and osteoporosis after their long-term usage. Recently, we identified novel roles of Substance-P (SP) in the suppression of the injury-mediated inflammation and also in stem cell mobilization. In this study, for clinical application of SP as an anti-inflammatory agent, its safety in long-term usage was evaluated with regard to diabetes and osteoporosis. Dexamethasone (DEX) and methylprednisolone (...
10 CitationsSource