Liane I.F. Moura
University of Lisbon
CancerInternal medicineEndocrinologyAntigenReceptorChemistryIn vivoGrowth factorInflammationDiabetic footNeurotensinWound healingCancer researchDiabetes mellitusDendrimerComputational biologyMedicineBiologyImmune systemCell biology
Publications 26
#1Carina Peres (University of Lisbon)H-Index: 7
#1Carina Peres (IMM: Instituto de Medicina Molecular)
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 10 authors...
Abstract The remarkable success of targeted immunotherapies is revolutionizing cancer treatment. However, tumor heterogeneity and low immunogenicity, in addition to several tumor-associated immunosuppression mechanisms are among the major factors that have precluded the success of cancer vaccines as targeted cancer immunotherapies. The exciting outcomes obtained in patients upon the injection of tumor-specific antigens and adjuvants intratumorally, reinvigorated interest in the use of nanotechno...
#1Joana R. Pedro (UC: University of Coimbra)H-Index: 5
#2Liane I.F. Moura (UC: University of Coimbra)H-Index: 14
Last. Attila Köfalvi (UC: University of Coimbra)H-Index: 24
view all 17 authors...
Abstract Here we aimed to unify some previous controversial reports on changes in both cannabinoid CB1 receptor (CB1R) expression and glucose metabolism in the forebrain of rodent models of diabetes. We determined how glucose metabolism and its modulation by CB1R ligands evolve in the frontal cortex of young adult male Wistar rats, in the first 8 weeks of streptozotocin-induced type-1 diabetes (T1D). We report that frontocortical CB1R protein density was biphasically altered in the first month o...
#1Liane I.F. Moura (University of Hertfordshire)H-Index: 14
#2Alessio MalfantiH-Index: 7
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 9 authors...
Well-defined synthetic branched nanostructures form an emerging subclass of macromolecular structures whose 3D structure and multivalency offer unique opportunities for fine-tuning internalization and cellular targeting. Dendrimers possess a well-defined 3D-globular backbone with highly versatile functional surface groups and exhibit a range of chemical and biological properties. Branched polymers present unique opportunities for the targeted delivery of diverse bioactive molecules (including ta...
14 CitationsSource
#1Ana I. Matos (University of Lisbon)H-Index: 11
#2Barbara Carreira (University of Lisbon)H-Index: 3
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 13 authors...
Abstract Colorectal cancer (CRC) is among the five most commonly diagnosed cancers worldwide, constituting 6% of all cancers and the third leading cause of cancer death. CRC is the third and second most frequent cancer in men and women worldwide, accounting for 14% and 13% of all cancer incidence rates, respectively. CRC incidence is decreasing in older populations, but it has been significantly rising worldwide in adolescents and adults younger than 50 years old. Significant advances in the scr...
13 CitationsSource
#1João Conniot (TAU: Tel Aviv University)H-Index: 6
#2Anna Scomparin (TAU: Tel Aviv University)H-Index: 18
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 16 authors...
A low response rate, acquired resistance and severe side effects have limited the clinical outcomes of immune checkpoint therapy. Here, we show that combining cancer nanovaccines with an anti-PD-1 antibody (αPD-1) for immunosuppression blockade and an anti-OX40 antibody (αOX40) for effector T-cell stimulation, expansion and survival can potentiate the efficacy of melanoma therapy. Prophylactic and therapeutic combination regimens of dendritic cell-targeted mannosylated nanovaccines with αPD-1/αO...
52 CitationsSource
#1Liane I.F. Moura (UC: University of Coimbra)H-Index: 14
#2Cristina Lemos (UC: University of Coimbra)H-Index: 13
Last. Attila Köfalvi (UC: University of Coimbra)H-Index: 24
view all 5 authors...
Abstract Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis via convergent signaling pathways that are impacted by diabetes. Here we asked how glucose metabolism and important facets of insulin signaling are affected in the forebrain of cannabinoid CB1 receptor knockout mice (CB1R-KO) and their wild-type (WT) littermates, seven weeks after the induction of insulinopenia/hyperglycemia (diabetes) with intraperitoneal streptozotocin injection. Sham-injected anima...
3 CitationsSource
#1Vanessa Sainz (UCL: University College London)H-Index: 4
#2Liane I.F. Moura (University of Hertfordshire)H-Index: 14
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 14 authors...
Abstract α-Galactosylceramide (GalCer) is a glycolipid widely known as an activator of Natural killer T (NKT) cells, constituting a promising adjuvant against cancer, including melanoma. However, limited clinical outcomes have been obtained so far. This study evaluated the synergy between GalCer and major histocompatibility complex (MHC) class I and MHC class II melanoma-associated peptide antigens and the Toll-Like Receptor (TLR) ligands CpG and monophosphoryl lipid A (MPLA), which we intended ...
11 CitationsSource
#1Ana I. Matos (University of Lisbon)H-Index: 11
#2Carina Peres (University of Lisbon)H-Index: 7
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 9 authors...
Introduction Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the fourth cause of cancer death worldwide. It is respossible for approximately 7 00 000 deaths per year. This work focused on the development of a combinatorial multivalent nanoplatform for CRC immunotherapy and immunomodulation based on the design of polymeric nanoparticles (NP) able to deliver a combination of CRC-associated antigen, adjuvants and gene regulators according to targeted cells, dendritic cell (D...
#1Liane I.F. Moura (University of Lisbon)H-Index: 14
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 7 authors...
Introduction Melanoma is the most dangerous type of skin cancer and novel treatments are needed. Alternative therapeutics should be devised isolated or in combination with targeted immunotherapies, to efficiently stimulate specific anti-tumour responses. Branched polypeptides exhibit advanced engineered complexity and unique structural properties inaccessible to linear polymers that make them ideal drug delivery systems with enhanced biological performance. Branched nanosystems have the ability ...
#1Ana Luisa Silva (University of Lisbon)H-Index: 9
#2Liane I.F. Moura (University of Lisbon)H-Index: 14
Last. Helena F. Florindo (University of Lisbon)H-Index: 21
view all 10 authors...
Abstract Particulate delivery systems can protect entrapped material from chemical and enzymatic degradation, resulting in increased blood circulation time, by avoiding the uptake by the mononuclear phagocyte system and rapid clearance via the kidneys. In addition, those carriers allow the concomitant delivery of multiple components for a sustained release of the entrapped active molecules, prolonging their therapeutic effects. To achieve a specific therapeutic outcome, the scientific community ...
1 CitationsSource