Rita T. Lawlor
University of Verona
GeneBiobankCancerInternal medicineGermline mutationPathologyOncologySingle-nucleotide polymorphismImmunohistochemistryPancreatic diseaseImmunotherapyPancreasNeuroendocrine tumorsPancreatic cancerAdenocarcinomaKRASPancreatic ductal adenocarcinomaCancer researchGeneticsCarcinogenesisMedicineBiology
Publications 155
#1Claudio LuchiniH-Index: 31
#2Andrea MafficiniH-Index: 24
Last. Antonio Pea (University of Bari)
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Pancreatic ductal adenocarcinoma (PDAC) with microsatellite instability (MSI)/defective mismatch repair (dMMR) is the only subtype of pancreatic cancer with potential response to immunotherapy. Here, we report the histo-molecular characterization of MSI/dMMR PDAC with immunohistochemistry, MSI-based PCR, and next-generation sequencing. Five paradigmatic cases have been identified. The main results include the first report in pancreatic cancer of MSI/dMMR intra-tumor heterogeneity, the presence o...
#1David Osuna de la Peña (UCL: University College London)
#2Sara Trabulo (QMUL: Queen Mary University of London)H-Index: 16
Last. Aldo Scarpa (University of Verona)H-Index: 99
view all 13 authors...
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully recapitulate in vivo tumour biology are urgently needed. These may especially benefit the management of pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high cancer stem cell (CSC) content and high density of stromal cells and extracellular matrix (ECM). To date, these fea...
3 CitationsSource
Hepatoid tumors (HT) are rare neoplasms morphologically resembling hepatocellular carcinoma, which arise in several organs other than the liver. A comprehensive molecular profile of this group of neoplasms is still lacking. Genomic characterization of 19 HTs from different organs (three colon HTs, four esophagogastric HTs, four biliary HTs, six genitourinary HTs, two lung HTs) was performed using a multigene next-generation sequencing panel. NGS unraveled a composite molecular profile of HT. The...
#1G. Peduzzi (UniPi: University of Pisa)
#2Manuel Gentiluomo (UniPi: University of Pisa)H-Index: 6
Last. Luca Morelli (UniPi: University of Pisa)H-Index: 21
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BACKGROUND The mitochondrial metabolism has been associated with pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also suggests the involvement of the genetic variability of the mitochondrial function in several traits involved in PDAC etiology. However, a systematic investigation of the genetic variability of mitochondrial genome (mtSNP) and of all the nuclear genes involved in its functioning (n-mtSNPs) has never been reported. METHODS We conducted a two-phase association study of...
#1Concetta Sciammarella (University of Verona)H-Index: 1
#2Maria BencivengaH-Index: 11
Last. Paola MattioloH-Index: 3
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Mixed neuroendocrine/non-neuroendocrine neoplasms (MiNEN) are rare mixed epithelial neoplasms in which a neuroendocrine component is combined with a non-neuroendocrine component. Here, we provide the clinical, pathologic, and molecular report of a 73-year-old-man presenting with an intestinal MiNEN. The lesion was composed of a well-differentiated G3 neuroendocrine tumor and a colloid adenocarcinoma. The molecular characterization was performed using a multigene next-generation sequencing panel....
#1Ye Lu (DKFZ: German Cancer Research Center)
#5George Theodoropoulos (UoA: National and Kapodistrian University of Athens)H-Index: 31
Last. Jakob R. Izbicki (UHH: University of Hamburg)H-Index: 75
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#1Rita T. LawlorH-Index: 31
#2Aldo ScarpaH-Index: 6
#1Giulio Innamorati (University of Verona)H-Index: 21
#2Thomas M. Wilkie (UTSW: University of Texas Southwestern Medical Center)H-Index: 33
Last. Samuele Cheri (University of Verona)H-Index: 8
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The GNA15 gene is ectopically expressed in human pancreatic ductal adenocarcinoma cancer cells. The encoded Gα15 protein can promiscuously redirect GPCR signaling toward pathways with oncogenic potential. We sought to describe the distribution of GNA15 in adenocarcinoma from human pancreatic specimens and to analyze the mechanism driving abnormal expression and the consequences on signaling and clinical follow-up. We detected GNA15 expression in pre-neoplastic pancreatic lesions and throughout p...
#1Claudio LuchiniH-Index: 31
#2Rita T. LawlorH-Index: 31
Last. Aldo ScarpaH-Index: 99
view all 10 authors...
PURPOSE OF REVIEW Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by some types of malignancies, including pancreatic neuroendocrine tumors, to overcome the issue of telomere shortening, thus supporting tumor growth and cell proliferation. This review is focused on the most important achievements and opportunities deriving from ALT assessment in PanNET onco-pathology, highlighting the most promising fields in which such biomarker could be implemented in clin...
#9Anthony J. GillH-Index: 73
#9Euan J. DicksonH-Index: 16
Last. Anubhav MittalH-Index: 23
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Background: The long-term outcomes following surgical resection for pancreatic ductal adenocarcinoma (PDAC) remains poor, with only 20% of patients surviving 5 years after pancreatectomy. Patient selection for surgery remains sub-optimal largely due to the absence of consideration of aggressive tumor biology. Objective: The aim of this study was to evaluate traditional staging criteria for PDAC in the setting of molecular subtypes. Methods: Clinicopathological data were obtained for 5 independen...