Yuning Zhou
Shanghai Jiao Tong University
OsseointegrationStromal cellRegeneration (biology)KinaseChemistryMaterials scienceMesenchymal stem cellIn vivoOsteoclastAngiogenesisCartilageIcariinChondrocyteBone regenerationp38 mitogen-activated protein kinasesMAPK/ERK pathwaySignal transductionOvariectomized ratBone healingCell biology
13Publications
8H-index
299Citations
Publications 13
Newest
#1Zhipeng Gui (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Yue Hu (SJTU: Shanghai Jiao Tong University)
Last. Yuan-Jin Xu (SJTU: Shanghai Jiao Tong University)
view all 5 authors...
Due to the poor repair ability of cartilage tissue, regenerative medicine still faces great challenges in the repair of large articular cartilage defects. Quercetin is widely applied as a traditional Chinese medicine in tissue regeneration including liver, bone and skin tissues. However, the evidence for its effects and internal mechanisms for cartilage regeneration are limited. In the present study, the effects of quercetin on chondrocyte function were systematically evaluated by CCK8 assay, PC...
Source
#1Lu Liu (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Xiuhui Wang (SHU: Shanghai University)H-Index: 2
Last. Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
view all 7 authors...
Accumulating evidence indicates much higher failure rates for biomedical titanium implants in diabetic patients. This phenomenon is attributed to impaired osteoblastic function, suppressed angiogenesis capacity, and abnormal osteoclast activation in diabetic patients. Our previous study demonstrated that titanium implants coated with highly crystalline nanostructured hydroxyapatite (nHA) promoted the osteogenic differentiation of bone marrow stromal cells (BMSCs) and bone–implant osseointegratio...
6 CitationsSource
#1Yue Hu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Zhipeng Gui (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 6 authors...
Abstract Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the degeneration and destruction of the articular cartilage. Cartilage matrix degradation, production of proinflammatory mediators, chondrocyte apoptosis and activation of macrophages in the synovial are involved in OA pathogenesis. Current non-surgical therapies for OA mainly aim at relieving pain but can barely alleviate the progression of OA. Quercetin, a naturally occurring flavonoid has shown pot...
23 CitationsSource
#1Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
#2Wudi Ma (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 10 authors...
Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone regeneration. In the present study, the effects of the addition of boron containing bioactive glass (B-BG) materials on the mechanical properties and biological performance of PCL polymer were investigate...
6 CitationsSource
#1Wenjun Sun (Tongji University)H-Index: 2
#2Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. Kaili Lin (Tongji University)H-Index: 8
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Abstract Injectable bioactive ceramics with excellent osteogenesis play important roles in bone regeneration field. In this study, we creatively fabricated the injectable nano-structured silicon-containing hydroxyapatite (Si-HAp) microspheres in diameter of 70–100 µm via hydrothermal treatment of calcium silicate (CaSiO3) microspheres in Na3PO4 aqueous solution. The fabricated Si-HAp microspheres were constructed by nano-rods with a diameter of 100 nm and length up to 1.5 µm. Comparing with the ...
7 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lingyan Cao (SJTU: Shanghai Jiao Tong University)H-Index: 9
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 51
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Typically, bone regenerative medicine is applied to repair bone defects in patients with osteoporosis. Meanwhile, there is an urgent need to develop safe and cheap drugs that induce bone formation. Icariin, which is reported to promote the osteogenesis of stem cells in vitro, is the main active component of Herba Epimedii. However, whether icariin could repair bone defects caused by osteoporosis remains unknown. In this study, an osteoporosis model in rats was established by an ovariectomy first...
27 CitationsSource
#1Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 9 authors...
Bone regeneration under osteoporotic conditions with impaired angiogenesis, osteogenesis and remodeling represents a great challenge. In the present study, the effects of quercetin on proliferation, osteogenic differentiation and angiogenic factor secretion as well as on the osteoclastogenic factor secretion of ovariectomized (OVX) rat bone marrow-derived mesenchymal stem cells (rBMSCs) were first evaluated in vitro. The role of mitogen-activated protein kinase (MAPK) signaling pathways and the ...
12 CitationsSource
#1Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
#2Na Zhang (CAS: Chinese Academy of Sciences)H-Index: 9
Last. Bing Fang (SJTU: Shanghai Jiao Tong University)H-Index: 17
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Control over the morphology and chemical composition of hydroxyapatite (HAp) bioceramic scaffolds is of great importance for their applications. In the present study, Si-substituted HAp bioceramic scaffolds with controllable morphologies (nanosheets and nanorods) were fabricated via hydrothermal treatment of calcium silicate scaffolds as precursors in NaH2PO4 and Na3PO4 aqueous solutions, respectively. Moreover, the effects of surface morphologies and Si substitution on cell attachment, prolifer...
29 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 51
view all 9 authors...
Icariin has been identified to promote osteogenic differentiation of bone mesenchymal stem cells (BMSCs). However, whether icariin could enhance angiogenic factor expression of BMSCs, which may be vital for bone repair, needs to be explored. Moreover, how to construct a delivery system of icariin and its repair capability in bone defects are still unknown. In the present study, the effects of icariin on the osteogenic differentiation and angiogenic factor expression of BMSCs were firstly evaluat...
18 CitationsSource
#1Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 7 authors...
Bone marrow-derived mesenchymal stem cells (BMSCs) are widely used in regenerative medicine in light of their ability to differentiate along the chondrogenic and osteogenic lineages. As a type of traditional Chinese medicine, quercetin has been preliminarily reported to promote osteogenic differentiation in osteoblasts. In the present study, the effects of quercetin on the proliferation, viability, cellular morphology, osteogenic differentiation and angiogenic factor secretion of rat BMSCs (rBMS...
56 CitationsSource