Shaokuan Fang
Jilin University
Internal medicineMagnetic resonance imagingCase-control studyRandomized controlled trialChemistryAdverse effectPlaceboFactor V LeidenParoxetineTolerabilityDiscontinuationGeneralized anxiety disorderPublication biasSpinal cordLesionWhite matterAnxietyMedicineMissense mutationMeta-analysis
29Publications
4H-index
56Citations
Publications 18
Newest
#1Shaokuan Fang (JLU: Jilin University)H-Index: 4
#2Yingying Cheng (JLU: Jilin University)H-Index: 1
Last. Beilin Zhang (JLU: Jilin University)H-Index: 1
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Cerebrovascular remodeling is the most common cause of hypertension and stroke. Ubiquitin E3 ligase RING finger protein 34 (RNF34) is suggested to be associated with the development of multiple neurological diseases. However, the importance of RNF34 in cerebrovascular remodeling and hypertension is poorly understood. Herein, we used mice with a global RNF34 knockout as well as RNF34 floxed mice to delete RNF34 in endothelial cells and smooth muscle cells (SMCs). Our results showed that global RN...
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#1Beilin Zhang (JLU: Jilin University)H-Index: 1
#2Fang Deng (JLU: Jilin University)H-Index: 1
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
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Acute ischemic stroke is a devastating disease with very limited therapeutics. Growing appreciation of dysregulated autophagy contributes to the progression of brain ischemic injury, making it to be an appealing intervention target. In terms of its well-characterized consequences, the signal molecules required for autophagy activation are rather poorly defined. Here, we found the induction of chloride channel-3 (ClC-3) directly activated autophagy, which played an important role in limiting cere...
1 CitationsSource
#1Rensheng Zhang (JLU: Jilin University)H-Index: 1
#2Jiguo Gao (JLU: Jilin University)H-Index: 2
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
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Immunoglobulin G4 (IgG4)-related disease is a systemic disease characterized by sclerosing lesions and an increased serum IgG4 level. This condition can involve any organ, but IgG4-related spinal pachymeningitis is relatively rare.In the current study, we report a case of spinal cord compression caused by IgG4-related spinal pachymeningitis.A 39-year-old man presented to us with a 15-day history of back pain and a 3-day history of dysuresia, exacerbated by weakness in the lower extremities for 2...
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#1Xinyuan Li (JLU: Jilin University)H-Index: 3
#2Yanbo Hou (JLU: Jilin University)H-Index: 1
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
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OBJECTIVE: The present study aimed to estimate the comprehensive efficacy and tolerability of paroxetine in adult patients with social anxiety disorder (SAD). METHODS: We conducted a comprehensive literature review of the PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and ClinicalTrials databases for eligible randomized controlled trials (RCTs). The efficacy outcome was the mean change of different kinds of scale scores as well as response and remission rates. Th...
2 CitationsSource
#1Beilin Zhang (JLU: Jilin University)
#2Chao Wang (JLU: Jilin University)H-Index: 2
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
view all 7 authors...
Objective: To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults. Methods: Multiple electronic databases were searched to find randomized controlled trials (RCTs) about paroxetine and panic disorder. The primary efficacy outcomes were the mean change from baseline in total number of full panic attacks and Clinical Global Impression-Severity of Illness (CGI-S) score, the proportion of participants with zero full panic attacks and with a 50%...
1 CitationsSource
#1Beilin Zhang (JLU: Jilin University)H-Index: 1
#2Ying Zhang (JLU: Jilin University)H-Index: 1
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
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Abstract Objective In the present study, we used a two-kidney-two-clip (2k2c) stroke-prone renovascular hypertension rat model (RHRSP) to investigate the protective effects of ligustrazine (TMP) on cerebral arteries and to examine PI3K/Akt pathway behavior under this protection. Methods The cerebral artery remodeling was induced by 2k2c-induced renovascular hypertension. Brain basilar artery tissues were isolated and their histological changes were detected through H&E and EVG staining, α-SMA IH...
1 CitationsSource
#1Chenglin Wang (JLU: Jilin University)H-Index: 2
#2Jiguo Gao (JLU: Jilin University)H-Index: 2
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
view all 8 authors...
OBJECTIVE: Cerebral small vessel diseases (CSVDs) are common causes of cognitive impairments and mood disorders. In recent years, event-related potential P300 has received increasing attention as a biomarker of cognitive impairments or mood disorders. Previous studies on P300 mainly focused on anxiety, depression or cognitive impairments, and few results have been reported on P300 in CSVD patients. The present study aimed to explore the relationship between neuropsychological test scores and P30...
2 Citations
#1Xinyuan LiH-Index: 3
#2Chunkui ZhouH-Index: 6
Last. Shaokuan FangH-Index: 4
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RATIONALE: Spinocerebellar ataxia (SCA), a genetically inherited heterogeneous disorder, is characterized by gait ataxia, dysarthria, parkinsonism, choreic movements, dystonia, epilepsy, cognitive and psychiatric symptoms. Spinocerebellar ataxia-42 (SCA42), caused by heterozygous mutation in the calcium channel 1G (CACNA1G) gene, is a rare SCA subtype and the transmission pattern is autosomal dominant inheritance. PATIENT CONCERNS: We presented a novel mutation (c.4721T>A; p.Met1574Lys) in 3 pat...
8 CitationsSource
#1Xinyuan Li (JLU: Jilin University)H-Index: 3
#2Li Cui (JLU: Jilin University)H-Index: 1
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
view all 7 authors...
Background Previous results regarding the prevalence of Factor V Leiden (FVL) in patients with cerebral venous thrombosis (CVT) varied remarkably. Therefore, we performed a meta-analysis to evaluate the potential association between FVL and CVT. Methods The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched for relevant case-control studies. The data were pooled for analysis of the association between FVL and CVT with a random-effects model. Subgroup...
2 CitationsSource
#1Li Xinyuan (JLU: Jilin University)
#2Hongliang Zhang (JLU: Jilin University)
Last. Shaokuan Fang (JLU: Jilin University)H-Index: 4
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Hereditary coproporphyria (HCP) is a form of porphyria arising from a deficiency of the enzyme, coproporphyrinogen oxidase, which results in the accumulation of coproporphyrin in the heme biosynthetic pathway. In the current study, we report a case of a 22-year-old male with a history of six recurrent intestinal obstructions, mainly presenting with reduced upper limb strength, photosensitive rash, and abdominal pain this admission. The laboratory tests revealed increased levels of coproporphyrin...
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