Dequina A. Nicholas
University of California, San Diego
Internal medicineDownregulation and upregulationEndocrinologyMolecular biologyGene knockdownChemistryGonadotropic cellGlycolysisImmunologyInflammationType 2 diabetesDendritic cellCytokineGonadotropinAnterior pituitaryImmunityAutoimmunitySecretionCancer researchBreast cancerDiabetes mellitusMedicineIndoleamine 2,3-dioxygenaseBiologyImmune systemCell biology
31Publications
11H-index
522Citations
Publications 30
Newest
#1Olivia Molinar-Inglis (UCSD: University of California, San Diego)H-Index: 3
#2Cierra A. Birch (UCSD: University of California, San Diego)H-Index: 1
Last. JoAnn TrejoH-Index: 50
view all 13 authors...
Endothelial dysfunction is associated with multiple vascular diseases and lacks effective treatment options. Activated Protein C (aPC) is a promising biotherapeutic that signals via protease-activated receptor-1 (PAR1) to promote diverse cytoprotective responses, including endothelial barrier stabilization, anti-inflammatory, and anti-apoptotic activities, which require specific co-receptors. We show that aPC-activated PAR1 signals preferentially via {beta}-arrestin-2 ({beta}-arr2) and dishevell...
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#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. Knight (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
The mechanisms mediating suppression of reproduction in response to decreased nutrient availability remain undefined, with studies suggesting regulation occurs within the hypothalamus, pituitary, or gonads. By manipulating glucose utilization and GLUT1 expression in a pituitary gonadotrope cell model and in primary gonadotropes, we show GLUT1-dependent stimulation of glycolysis, but not mitochondrial respiration, by the reproductive neuropeptide GnRH. GnRH stimulation increases gonadotrope GLUT1...
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#1Leena P. Bharath (Merrimack College)H-Index: 10
#2Madhur Agrawal (UK: University of Kentucky)H-Index: 7
Last. Barbara S. Nikolajczyk (UK: University of Kentucky)H-Index: 32
view all 21 authors...
Summary Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4+ T cells from lean, normoglycemic older and younger subjects, and mimics a diabetes-associated Th17 profile. T cells from older compared to younger subjects also had defects in autophagy and mitochondrial bioenergetics tha...
70 CitationsSource
#1Dequina A. Nicholas (UCSD: University of California, San Diego)H-Index: 11
#2Vashti S. KnightH-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 10 authors...
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#1Dequina A. Nicholas (LLU: Loma Linda University)H-Index: 11
#2Lorena M. Salto (LLU: Loma Linda University)H-Index: 5
Last. Marino De Leon (LLU: Loma Linda University)H-Index: 22
view all 9 authors...
Purpose. En Balance, a culturally sensitive diabetes education program, improves glycemic control in Hispanics with type 2 diabetes. The program emphasized diet, physical activity, and other factors important for glycemic control. However, the individual contributions of these education factors are unclear. The purpose of this study is to assess the contribution of physical activity to the success of En Balance in improving the health of Mexican Americans with type 2 diabetes. Methods. A retrosp...
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#1Olivia Molinar-Inglis (UCSD: University of California, San Diego)H-Index: 3
#2Lili Zhang (UCSD: University of California, San Diego)
Last. JoAnn Trejo (UCSD: University of California, San Diego)H-Index: 50
view all 12 authors...
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#1Alexis Garcia (UCSD: University of California, San Diego)
#2Olivia Molinar-Inglis (UCSD: University of California, San Diego)H-Index: 3
Last. JoAnn Trejo (UCSD: University of California, San Diego)H-Index: 50
view all 9 authors...
Source
#1Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
#2Danmei Li (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
: A defining characteristic of the hypothalamus-pituitary-gonad reproductive endocrine axis is the episodic secretion of the pituitary gonadotropin hormones LH and FSH by the anterior pituitary gonadotropes. Hormone secretion is dictated by pulsatile stimulation, with GnRH released by hypothalamic neurons that bind and activate the G protein-coupled GnRH receptor expressed by gonadotropes. Hormone secretion and synthesis of gonadotropins are influenced by the amplitude and frequency of GnRH stim...
5 CitationsSource
#1Dequina A. Nicholas (BU: Boston University)H-Index: 11
#2Elizabeth A. Proctor (MIT: Massachusetts Institute of Technology)H-Index: 18
Last. Barbara S. NikolajczykH-Index: 32
view all 20 authors...
Summary Mechanisms that regulate metabolites and downstream energy generation are key determinants of T cell cytokine production, but the processes underlying the Th17 profile that predicts the metabolic status of people with obesity are untested. Th17 function requires fatty acid uptake, and our new data show that blockade of CPT1A inhibits Th17-associated cytokine production by cells from people with type 2 diabetes (T2D). A low CACT:CPT1A ratio in immune cells from T2D subjects indicates alte...
36 CitationsSource
#1Tomohiro Terasaka (UCSD: University of California, San Diego)H-Index: 10
#2Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 9 authors...
: Gonadotropin secretion, which is elicited by GnRH stimulation of the anterior pituitary gonadotropes, is a critical feature of reproductive control and the maintenance of fertility. In addition, activation of the GnRH receptor (GnRHR) regulates transcription and translation of multiple factors that regulate the signaling response and synthesis of gonadotropins. GnRH stimulation results in a broad redistribution of mRNA between active and inactive polyribosomes within the cell, but the mechanis...
6 CitationsSource