Victoria Klang
University of Vienna
Penetration (firestop)Biomedical engineeringNanotechnologyCorneocyteChemistryMicroemulsionMaterials scienceRheologyIn vivoEmulsionStratum corneumSodium dodecyl sulfateLecithinDrug deliveryStripping (fiber)Chemical engineeringChromatographyPermeationPulmonary surfactantTransepidermal water loss
33Publications
14H-index
797Citations
Publications 33
Newest
#1Claudia VaterH-Index: 2
Last. Victoria KlangH-Index: 14
view all 7 authors...
(1) Background: The aim of the study was to evaluate the effect of pure lecithins in comparison to a conventional surfactant on skin in vivo. (2) Methods: Physiological skin parameters were evaluated at the beginning and the end of the study (day 1 and day 4) (n = 8, healthy forearm skin) with an Aquaflux®, skin-pH-Meter, Corneometer® and an Epsilon® sensor. Confocal Raman spectroscopy was employed to monitor natural moisturizing factor, urea and water content of the participants’ skin. Tape str...
Source
#1Astrid Pany (University of Vienna)H-Index: 2
#2Marie Wohlgenannt (University of Vienna)
Last. Victoria Klang (University of Vienna)H-Index: 14
view all 8 authors...
1 CitationsSource
#1Claudia Vater (University of Vienna)H-Index: 2
#2Victoria Hlawaty (University of Vienna)H-Index: 1
Last. Claudia Valenta (University of Vienna)H-Index: 34
view all 8 authors...
Abstract Surfactants are important ingredients in pharmaceutical and cosmetic formulations, as in creams, shampoos or shower gels. As conventional emulsifiers such as sodium dodecyl sulfate (SDS) have fallen into disrepute due to their skin irritation potential, the naturally occurring lecithins are being investigated as a potential alternative. Thus, lecithin-based nanoemulsions with and without the drug curcumin, known for its wound healing properties, were produced and characterised in terms ...
7 CitationsSource
#1Lisa Binder (University of Vienna)H-Index: 6
#2Victoria Klang (University of Vienna)H-Index: 14
Last. Claudia Valenta (University of Vienna)H-Index: 34
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Abstract Important aspects in the development of new dermal drug delivery systems are the formulations' physicochemical properties and stability. Moreover, their influence on skin physiology and their penetration performance in vivo are of crucial interest. We have recently developed novel concentrated water-in-oil emulsions based on a non-ionic silicone surfactant; the present study deals with the effect of these formulations on physiological skin parameters of healthy volunteers after repeated...
5 CitationsSource
#1Lisa Binder (University of Vienna)H-Index: 6
#2Julia Mazál (University of Vienna)H-Index: 1
Last. Claudia Valenta (University of Vienna)H-Index: 34
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BACKGROUND: The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetr...
9 CitationsSource
#1Astrid Pany (University of Vienna)H-Index: 2
#2Victoria Klang (University of Vienna)H-Index: 14
Last. Claudia Valenta (University of Vienna)H-Index: 34
view all 6 authors...
Abstract Cosmetic hair removal procedures are everyday routines in our society. However, it is unclear if such routines lead to increased uptake of applied substances such as drugs or formulation compounds, potentially resulting in skin irritation or sensitization. The aim of this study was to elucidate the effect of common depilation and epilation methods on skin penetration of two surfactants and four model drugs of different physicochemical properties using the porcine ear model. It should be...
3 CitationsSource
#1Claudia Vater (University of Vienna)H-Index: 2
#2Anja Adamovic (University of Vienna)H-Index: 1
Last. Claudia Valenta (University of Vienna)H-Index: 34
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Abstract As constituents of cellular membranes, lecithins feature high biocompatibility and great emulsifying properties due to their amphiphilicity. Additionally, there are expectations that these naturally occurring emulsifying agents can replace other skin damaging emulsifiers like sodium dodecyl sulfate or sodium laureth sulfate. However, cytotoxicity data of lecithin-based formulations on primary human skin cells are scarce. Thus, we developed nanoemulsions with different kinds of surfactan...
12 CitationsSource
#1Astrid PanyH-Index: 2
#2Victoria KlangH-Index: 14
Last. Claudia ValentaH-Index: 34
view all 6 authors...
Background: Although very common in our society, the effect of hair removal on physiological skin parameters and on the ingress of applied chemicals has not been systematically investigated. Thus, as a first step, the aim of the present study was to elucidate the effect of hair removal through epilation (electric epilation, waxing) and depilation (dry and wet shaving, depilatory cream) on skin properties in vitro using the porcine ear model. Methods: Attenuated total reflection Fourier transform...
7 CitationsSource
#1Martin Wolf (University of Vienna)H-Index: 4
#2Victoria Klang (University of Vienna)H-Index: 14
Last. Claudia Valenta (University of Vienna)H-Index: 34
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Abstract Nanostructured lipid carriers (NLC) and nano-sized emulsions based on monoacyl-phosphatidylcholine (MAPL) were tested for their effect on physiological skin parameters in vivo during daily application over four weeks. The influence of the basic formulations on transepidermal water loss (TEWL), skin hydration, sebum content and pH was determined once per week and after a recovery period of three weeks. In addition, confocal Raman spectroscopy was employed to evaluate natural moisturising...
9 CitationsSource
#1Lisa Binder (University of Vienna)H-Index: 6
#2Eva Maria Kulovits (University of Vienna)H-Index: 2
Last. Claudia Valenta (University of Vienna)H-Index: 34
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Abstract Vibrational spectroscopy is a useful tool for analysis of skin properties and to confirm the penetration of drugs and other formulation compounds into the skin. In particular, attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy and confocal Raman spectroscopy (CRS) have been optimised for skin analysis. Despite an impressive amount of data on these techniques, a comparative methodological assessment for skin penetration monitoring of model substances is still ...
14 CitationsSource