Jane E. Norman
University of Bristol
Internal medicineObstetricsEndocrinologyOdds ratioAndrologyRandomized controlled trialFetusPediatricsImmunologyInflammationCervixMyometriumGestational agePregnancyPopulationGynecologyGestationObesityMedicineBiology
Publications 432
#1Jane E. Norman (UoB: University of Bristol)H-Index: 68
#2Julia Lawton (Edin.: University of Edinburgh)H-Index: 49
Last. Jane BrewinH-Index: 6
view all 14 authors...
BACKGROUND: Around 60,000 babies are born preterm (prior to 37 weeks' gestation) each year in the UK. There is little evidence on the optimal birth mode (vaginal or caesarean section). OBJECTIVE: The overall aim of the CASSAVA project was to determine if a trial to define the optimal mode of preterm birth could be carried out and, if so, determine what sort of trial could be conducted and how it could best be performed. We aimed to determine the specific groups of preterm women and babies for wh...
#1Vicki Flenady (UQ: University of Queensland)H-Index: 55
#2Glenn Gardener (UQ: University of Queensland)H-Index: 20
Last. Frances M. Boyle (UQ: University of Queensland)H-Index: 59
view all 20 authors...
The My Baby's Movements (MBM) trial aimed to evaluate the impact on stillbirth rates of a multifaceted awareness package (MBM intervention). null Stepped-wedge cluster-randomised controlled trial. null Twenty-seven maternity hospitals in Australia and New Zealand. null Women with a singleton pregnancy without major fetal anomaly at ≥28 weeks' gestation from August 2016-May 2019. null The MBM intervention was implemented at randomly assigned time points with sequential introduction into 8 groups ...
#1Pamela Pruski (Imperial College London)H-Index: 4
#2Gonçalo Correia (Imperial College London)H-Index: 8
Last. Ann Smith (University College West)H-Index: 1
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The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of the cervicovaginal metabolome in two independent pregnancy cohorts (VMET, n = 160; 455 swabs; VMET II, n = 205; 573 swabs). By integrating metataxonomics and immune profiling data from matched samples, ...
#1William A. Grobman (NU: Northwestern University)H-Index: 44
#2Jane E. Norman (UoB: University of Bristol)H-Index: 68
Last. Bo JacobssonH-Index: 63
view all 3 authors...
A pessary is a device made of synthetic material that is placed in the vagina and has been used for prevention of preterm birth. It has been suggested that a potential mechanism of the pessary is alteration of the cervico-uterine angle to a more posterior position, which reduces cervical compression in women with a singleton pregnancy and a short cervical length. Pessaries should not be used in routine clinical care to reduce the frequency of preterm birth or to improve outcomes (e.g. neonatal o...
#1Jane E. Norman (UoB: University of Bristol)H-Index: 68
#2Andrew Shennan ('KCL': King's College London)H-Index: 70
Last. Sarah J. Stock (Edin.: University of Edinburgh)H-Index: 27
view all 4 authors...
For women with a singleton or a multiple pregnancy in situations where active neonatal care is appropriate, and for whom preterm birth is anticipated between 24 and 34 weeks of gestation, one course of prenatal corticosteroids should ideally be offered 18 to 72 h before preterm birth is expected to improve outcomes for the baby. However, if preterm birth is expected within 18 h, prenatal corticosteroids should still be administered. One course of corticosteroids includes two doses of betamethaso...
#1Sarah J. Stock (Edin.: University of Edinburgh)H-Index: 27
#2Margaret Horne (Edin.: University of Edinburgh)H-Index: 5
Last. Jon Dorling (Halifax)H-Index: 21
view all 24 authors...
BACKGROUND The diagnosis of preterm labour is challenging. False-positive diagnoses are common and result in unnecessary, potentially harmful treatments (e.g. tocolytics, antenatal corticosteroids and magnesium sulphate) and costly hospital admissions. Measurement of fetal fibronectin in vaginal fluid is a biochemical test that can indicate impending preterm birth. OBJECTIVES To develop an externally validated prognostic model using quantitative fetal fibronectin concentration, in combination wi...
#1Sarah J. StockH-Index: 27
#2Margaret HorneH-Index: 5
Last. Jon DorlingH-Index: 21
view all 24 authors...
#1Victoria Hodgetts-Morton (University of Birmingham)H-Index: 2
#2Catherine HewittH-Index: 8
Last. Sarah J. Stock (Edin.: University of Edinburgh)H-Index: 27
view all 22 authors...
Cervical cerclage is a recognised treatment to prevent late miscarriage and pre-term birth (PTB). Emergency cervical cerclage (ECC) for cervical dilatation with exposed unruptured membranes is less common and the potential benefits of cerclage are less certain. A randomised control trial is needed to accurately assess the effectiveness of ECC in preventing pregnancy loss compared to an expectant approach. C-STICH2 is a multicentre randomised controlled trial in which women presenting with cervic...
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