Elizabeth Mary Huddleston
Smith & Nephew
MicrocirculationBiomedical engineeringPlastic surgeryDehiscenceSurgeryPathologyBlood flowContraction (grammar)ProteasesMaterials scienceIn vivoGranulation tissueSubcutaneous tissueSalineMuscle tissueWound assessmentNegative-pressure wound therapyPolyurethaneReduction (orthopedic surgery)Wound healingLeakVenous leg ulcerMammaplastyChronic woundCatheterWound edgeWound.exudateWound fluidOpen cellPressure transmissionTreatment periodDisease severityResponse to treatmentFull thicknessHealing timeClinical performanceNew deviceVacuum assisted closureDelayed healingPatient factorsSingle useClinical evaluationSurgical woundFluid handlingSingle patientAnesthesiaLaser Doppler velocimetryClinical trialBioinformaticsMedicineTransepidermal water loss
Publications 7
#1Varuni R. Brownhill (Smith & Nephew)H-Index: 1
#2Elizabeth Mary Huddleston (Smith & Nephew)H-Index: 6
Last. Holly N. Wilkinson (Hull York Medical School)H-Index: 8
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Objective: Traditional negative pressure wound therapy systems can be large and cumbersome, limiting patient mobility and adversely affecting quality of life. PICO™, a no canister single-use system offers a lightweight, portable alternative to traditional negative pressure wound therapy, with improved clinical performance. The aim of this study was to determine the potential mechanism(s) of action of single-use negative pressure wound therapy versus traditional negative pressure wound therapy. A...
2 CitationsSource
#1Robert D. GalianoH-Index: 45
#2Donald A. Hudson (UCT: University of Cape Town)H-Index: 41
Last. Elizabeth Mary Huddleston (Smith & Nephew)H-Index: 6
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Background:It has been proposed that negative pressure wound therapy (NPWT) applied prophylactically to a closed incision may decrease the incidence of wound complications. Patients undergoing reduction mammaplasty are at risk of wound complications such as delayed healing, infection, and dehiscence
32 CitationsSource
#1Donald A. Hudson (UCT: University of Cape Town)H-Index: 41
#2Kevin Adams (UCT: University of Cape Town)H-Index: 8
Last. Elizabeth Mary Huddleston (Smith & Nephew)H-Index: 6
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The aim of this study was to evaluate a prototype negative pressure wound therapy (NPWT) system that has been developed to simplify NPWT for wounds at the lower end of the acuity scale. The new device has a single preset pressure of −80 mmHg, is single use and operates without an exudate canister. The disposable NPWT system (PICO™) was tested in a prospective, non-comparative, multicentre clinical trial to assess device functionality and clinical acceptance. Twenty patients were recruited for a ...
38 CitationsSource
#1Malin Malmsjö (Lund University)H-Index: 41
#2Elizabeth Mary Huddleston (Smith & Nephew)H-Index: 6
Last. Robin Martin (Smith & Nephew)H-Index: 22
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Objective: Recent developments of negative pressure wound therapy (NPWT) systems have focused on making pumps smaller, lighter, and more portable. The recently introduced PICO system manages wound fluid through a highly breathable film within the dressing, thereby negating the need for a canister, which allows greater mobility and patient concordance. The aim of this study is to compare the biological effects of this system compared to a traditional NPWT system. Methods: Laboratory tests were ca...
33 Citations
#1Malin Malmsjö (Lund University)H-Index: 41
#2Richard IngemanssonH-Index: 38
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The aim of this study was to examine the effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow, comparing different wound fillers. Wounds were created on the backs of 7 pigs. NPWT was applied, using either foam or gauze, at -50,-75, -100, -125, -150, or -175 mm Hg. Microvascular blood flow was measured in muscle tissue, subcutaneous tissue, and in the wound bed, at 0.5, 1, and 2.5 cm from the wound edge, using laser Doppler velocimetry. Similar patterns of bloo...
97 CitationsSource
#1Malin Malmsjö (Lund University)H-Index: 41
#1Malin Malmsjö (Lund University)H-Index: 5
Last. Elizabeth Mary Huddleston (Smith & Nephew)H-Index: 6
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Negative-pressure wound therapy (NPWT), also known as topical negative-pressure therapy, is widely used to manage wounds and accelerate healing. NPWT has so far been delivered mainly via open-cell polyurethane foam, but increasing interest has been directed toward delivering NPWT via gauze. In the present study, the early effects of NPWT on pressure transduction and wound contraction were examined in wounds filled with either polyurethane foam or gauze. An experimental setup of a porcine wound m...
146 CitationsSource
#1Keith MooreH-Index: 5
#2Elizabeth Mary Huddleston (Smith & Nephew)H-Index: 6
Last. Keith Harding (Cardiff University)H-Index: 76
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Disordered cell function within chronic wounds generates many parameters that can be measured to differentiate between healing and non healing status. Theoretically, these may form the basis of a wound assessment system to define disease severity and response to treatment. In a review of tissue, wound exudate and microbiology studies of venous leg ulcers, we identify many such parameters that are associated with healing status. These include cytokines, proteases and their inhibitors, senescence ...
53 CitationsSource