Yutaka Midorikawa
Nihon University
GeneCancerInternal medicineRadiologySurgeryPathologyOncologyResectionDNA methylationHazard ratioLiver cancerHepatectomyCirrhosisCarcinomaHepatocellular carcinomaMetastasisHCCSMethylationConfidence intervalCancer researchColorectal cancerGeneticsMedicineBiologyGastroenterology
134Publications
31H-index
3,758Citations
Publications 136
Newest
#1Sumie Ohni (Nihon University)H-Index: 7
#2Hiromi Yamaguchi (Nihon University)H-Index: 7
Last. Mariko Esumi (Nihon University)H-Index: 22
view all 10 authors...
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#1Kazu Shibutani (Nihon University)H-Index: 1
#2Masahiro Okada (Nihon University)H-Index: 25
Last. Tadatoshi Takayama (Nihon University)H-Index: 92
view all 10 authors...
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Source
#1Tadatoshi Takayama (Nihon University)H-Index: 92
#2Yutaka Midorikawa (Nihon University)H-Index: 31
Last. Masatoshi MakuuchiH-Index: 135
view all 10 authors...
OBJECTIVE: To propose an algorithm for resecting hepatocellular carcinoma (HCC) in the caudate lobe. BACKGROUND: Owing to a deep location, resection of HCC originating in the caudate lobe is challenging, but a plausible guideline enabling safe, curable resection remains unknown. METHODS: We developed an algorithm based on sublocation or size of the tumor and liver function to guide the optimal procedure for resecting HCC in the caudate lobe, consisting of 3 portions (Spiegel, process, and caval)...
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#1Kiyokazu Shirai (UTokyo: University of Tokyo)H-Index: 1
#2Genta Nagae (UTokyo: University of Tokyo)H-Index: 31
Last. Hiroyuki Aburatani (UTokyo: University of Tokyo)H-Index: 126
view all 18 authors...
Ten-eleven translocation 1 (TET1) is an essential methylcytosine dioxygenase of the DNA demethylation pathway. Despite its dysregulation being known to occur in human cancer, the role of TET1 remains poorly understood. In this study, we report that TET1 promotes cell growth in human liver cancer. The transcriptome analysis of 68 clinical liver samples revealed a subgroup of TET1-upregulated hepatocellular carcinoma (HCC), demonstrating hepatoblast-like gene expression signatures. We performed co...
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#1Tadatoshi Takayama (Nihon University)H-Index: 92
#2Shintaro Yamazaki (Nihon University)H-Index: 17
Last. Osamu Nakashima (Kurume University)H-Index: 50
view all 13 authors...
BACKGROUND Surgical treatment for hepatocellular carcinoma (HCC) is advancing, but a robust prediction model for survival after resection is not available. The aim of this study was to propose a prognostic grading system for resection of HCC. METHODS This was a retrospective, multicentre study of patients who underwent first resection of HCC with curative intent between 2000 and 2007. Patients were divided randomly by a cross-validation method into training and validation sets. Prognostic factor...
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#1Hayato Abe (Nihon University)H-Index: 5
#2Yutaka Midorikawa (Nihon University)H-Index: 31
Last. Tadatoshi Takayama (Nihon University)H-Index: 92
view all 14 authors...
Abstract Background Liver stiffness measurement using magnetic resonance elastography can assess the severity of liver fibrosis, which is significantly associated with recurrence after curative resection for hepatocellular carcinoma. The aim of this prospective study was to investigate whether preoperative liver stiffness measurement by magnetic resonance elastograhy can predict recurrence after curative resection for hepatocellular carcinoma. Methods Patients who underwent preoperative liver st...
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#1Kazu Shibutani (Nihon University)H-Index: 1
#2Masahiro Okada (Nihon University)H-Index: 25
Last. Tadatoshi Takayama (Nihon University)H-Index: 92
view all 9 authors...
Purpose To retrospectively compare the predictive value of computed tomography volumetry (CTV), magnetic resonance elastography (MRE) of the liver, and their combination for major complications after liver resection. Methods We enrolled 108 consecutive patients who underwent anatomical liver resection for liver tumors and preoperative contrast-enhanced CT and MRE. The future liver remnant (FLR) ratio was calculated by CTV, while the liver stiffness measurement (LSM) was obtained by MRE. FLR rati...
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#1Masaharu Harada (Nihon University)
#2Osamu Aramaki (Nihon University)H-Index: 10
Last. Tadatoshi Takayama (Nihon University)H-Index: 92
view all 7 authors...
There is little information on the impact of aging on liver resection of hepatocellular carcinoma (HCC). The aim of study was to evaluate the prognostic impact of the patient's age on the long-term survival after resection of HCC. The postoperative outcomes of the 291 elderly (≥ 70 years) and 340 younger (< 70 years) patients underwent curative liver resection for HCC were analyzed using multivariate and propensity-score matching. Risk score were calculated from the results of Cox regression ana...
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#1Susumu Mochizuki (Nihon University)H-Index: 18
#2Hisashi Nakayama (Nihon University)H-Index: 16
Last. Tadatoshi Takayama (Nihon University)H-Index: 92
view all 7 authors...
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