Tomotsugu Ichikawa
Okayama University
Genetic enhancementTransduction (genetics)Internal medicineRadiologySurgeryPathologyMagnetic resonance imagingMolecular biologyIntegrinImmunohistochemistryIn vivoChemotherapyBevacizumabGliomaBrain tumorCilengitideAngiogenesisCancer researchMedicineBiology
110Publications
22H-index
1,694Citations
Publications 111
Newest
#2Tomotsugu IchikawaH-Index: 22
Last. Masamitsu KawauchiH-Index: 10
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#1Seunghyun Lee (Seoul National University Hospital)H-Index: 10
#2Seung Hong ChoiH-Index: 53
Last. Tomotsugu Ichikawa (Okayama University)H-Index: 22
view all 6 authors...
Purpose To assess glioblastoma multiforme (GBM) formation with similar imaging characteristics to human GBM using multiparametric magnetic resonance imaging (MRI) in an orthotopic xenograft canine GBM model. null null Materials and methods The canine GBM cell line J3T1 was subcutaneously injected into 6-week-old female BALB/c nude mice to obtain tumour fragments. Tumour fragments were implanted into adult male mongrel dog brains through surgery. Multiparametric MRI was performed with conventiona...
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#1Shunsuke Noguchi (OPU: Osaka Prefecture University)H-Index: 16
#2Marina Inoue (OPU: Osaka Prefecture University)
Last. Hiroaki Kamishina (Gidai: Gifu University)H-Index: 8
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Abstract Canine glioma is a common brain tumor with poor prognosis despite surgery and/or radiation therapy. Therefore, newer and more effective treatment modalities are needed. Neuregulin 3 (NRG3) has known to be a ligand of ERBB4. This study aimed to investigate the usefulness of the NRG3/ERBB4 signaling cascade as a novel therapeutic target in canine glioma. We found out that microRNA (miR)-190a was downregulated in canine brain tumor tissues, including glioma and meningioma. miR-190a directl...
1 CitationsSource
#1Motomasa Furuse (Osaka Medical College)H-Index: 14
#2Hiroko Kuwabara (Osaka Medical College)H-Index: 16
Last. Shin-Ichi Miyatake (Osaka Medical College)H-Index: 38
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BACKGROUND: The prevalence of programmed death-ligand 1 (PD-L1) and PD-L2 expression on tumor cells and tumor-infiltrating immune cells in primary central nervous system lymphoma (PCNSL) remains unclear. In the present study, we analyzed needle biopsy and craniotomy specimens of patients with PCNSL to compare the PD-L1 and PD-L2 levels in the tumor and surrounding (peritumoral) tissue. We also assessed the correlation between biological factors and the prognostic significance of PD-L1 and PD-L2 ...
11 CitationsSource
#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
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Glioblastoma (GBM) is characterized by extensive tumor cell invasion, angiogenesis, and proliferation. We previously established subclones of GBM cells with distinct invasive phenotypes and identified annexin A2 (ANXA2) as an activator of angiogenesis and perivascular invasion. Here, we further explored the role of ANXA2 in regulating phenotypic transition in GBM. We identified oncostatin M receptor (OSMR) as a key ANXA2 target gene in GBM utilizing microarray analysis and hierarchical clusterin...
4 CitationsSource
#1Tomotsugu IchikawaH-Index: 22
#2Satoshi MinoH-Index: 1
Last. Hideaki YokooH-Index: 27
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#1Jongha LeeH-Index: 8
#2Hye Rim Cho (New Generation University College)
Last. Dae-Hyeong Kim (SNU: Seoul National University)H-Index: 72
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Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intrac...
50 CitationsSource
#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu IchikawaH-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 14 authors...
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#1Yusuke Tomita (Okayama University)H-Index: 6
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
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Anti-vascular endothelial growth factor treatments such as bevacizumab have demonstrated convincing therapeutic advantage in glioblastoma patients. However, bevacizumab has also been reported to induce invasiveness of glioma. In this study, we examined the effects of Rapid Antiangiogenesis Mediated By Oncolytic virus (RAMBO), an oncolytic herpes simplex virus-1 expressing vasculostatin, on bevacizumab-induced glioma invasion. The effect of the combination of RAMBO and bevacizumab in vitro was as...
10 CitationsSource
#1Yuji Matsumoto (Okayama University)H-Index: 6
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
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Objective Supratentorial cortical ependymomas (CEs) are rare. These lesions, selectively occurring in the superficial cortex, have not been fully characterized. We analyzed the clinicopathological and genetic features of CEs. Methods Eight patients with CEs from our institution and 84 other reported CE cases were included in the present study. We retrospectively reviewed their clinical characteristics, imaging findings, treatment methods, pathological features, molecular status, and clinical out...
6 CitationsSource