Anne M. Dickinson
Newcastle University
HaematopoiesisInternal medicineOncologySingle-nucleotide polymorphismCytotoxic T cellHuman leukocyte antigenIn vitroImmunologyT cellHematopoietic stem cell transplantationCytokineDiseaseGraft-versus-host diseaseBone marrowStem cellTransplantationCancer researchMedicineBiologyImmune system
Publications 300
#1Wei Yu Lin (Newcastle University)H-Index: 2
#2Sarah E. Fordham (Newcastle University)H-Index: 10
Last. Christian Gieger (LMU: Ludwig Maximilian University of Munich)H-Index: 151
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Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765;...
#1Joanna Wielińska (PAN: Polish Academy of Sciences)H-Index: 2
#2Rachel E. Crossland (Newcastle University)H-Index: 8
Last. Katarzyna Bogunia-Kubik (PAN: Polish Academy of Sciences)H-Index: 22
view all 7 authors...
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) belong to the most common inflammatory rheumatic diseases. MicroRNAs (miRNAs) are small 18–22 RNA molecules that function as posttranscriptional regulators. They are abundantly present within extracellular vesicles (EVs), small intercellular communication vesicles that can be found in bodily fluids and that have key functions in pathological and physiological pathways. Recently, EVs have gained much interest because of their diagnostic an...
#2Jean NordenH-Index: 16
Last. Anne M. DickinsonH-Index: 42
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Introduction: Acute graft vs. host disease (aGvHD) is a frequent complication following allogeneic haematopoeitic transplantation (HSCT). Despite recent advances, there are no universally accepted biomarkers to determine development of aGvHD. MicroRNAs miR-146a and miR-155 have been previously associated with aGvHD and show promise as clinically translatable biomarkers. In this study, we performed comprehensive expression profiling of miR-146a, miR-155, and miR-155* expression in aGvHD target ti...
With the reduction or elimination of animal testing, manufacturers are left with limited options, as few robust in vitro tests are available and human studies are costly. Recently, concerns have been raised regarding potential adverse health effects associated with use of WEN by Chaz Dean (WCD) cleansing conditioners. The purpose of this study was to evaluate the immunogenic potential of a WCD hair cleansing conditioner by utilizing a novel in vitro human skin explant test. Peripheral blood mono...
#1Rachel E. Crossland (Newcastle University)H-Index: 8
#2Francesca Perutelli (UNITO: University of Turin)H-Index: 4
Last. Magdalena GrceH-Index: 20
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Prognostic, diagnostic or predictive biomarkers are urgently needed for assessment of chronic graft-versus-host disease (cGvHD), a major risk for patients undergoing allogeneic hematopoietic stem cell transplantation. The main goal of this review generated within the COST Action EUROGRAFT “Integrated European Network on Chronic Graft Versus Host Disease” was to identify potential novel biomarkers for cGvHD besides the widely accepted molecular and cellular biomarkers. Thus, the focus was on cell...
#1Nathaniel Edward Bennett Saidu (Oslo University Hospital)H-Index: 14
#2Chiara BoniniH-Index: 62
Last. Sara Galimberti (UniPi: University of Pisa)H-Index: 30
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Chronic graft-versus-host disease (cGvHD) is a severe complication of allogeneic hematopoietic stem cell transplantation that affects various organs leading to a reduced quality of life. The condition often requires enduring immunosuppressive therapy, which can also lead to the development of severe side effects. Several approaches including small molecule inhibitors, antibodies, cytokines, and cellular therapies are now being developed for the treatment of cGvHD, and some of these therapies hav...
Fms-like tyrosine kinase 3 (Flt3) is expressed on progenitor cells and acute myeloid leukemia (AML) blasts. Fms-like tyrosine kinase 3 ligand (Flt3L) is detectable during homeostasis and increases in hypoplasia due to genetic defects or treatment with cytoreductive agents. Conversely, Flt3+ AML is associated with depletion of Flt3L to undetectable levels. After induction chemotherapy, Flt3L is restored in patients entering complete remission (CR) but remains depressed in those with refractory di...
#1Anne M. Dickinson (Newcastle University)H-Index: 42
#2Jessica M. Godden (Newcastle University)H-Index: 1
Last. S AhmedH-Index: 6
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Abstract Over the past decade, there has been a significant increase in preclinical development and clinical use of approved nanomedicines. The nanomedicinal field represents a wide variety of prod...
#1Sylvia Müller (Newcastle University)H-Index: 1
#2L Nicholson (Newcastle University)H-Index: 1
Last. Kenneth W. Dalgarno (Newcastle University)H-Index: 21
view all 8 authors...
Mesenchymal stromal cells (MSCs) are widely used in clinical trials for bone repair and regeneration. Despite previous evidence showing a prominent osteogenic potential of 2D cultured CD271 enriched MSCs, the osteogenic potential of CD271 enriched cells cultured on 3D scaffold is unknown. Apatite-wollastonite glass ceramic (A-W) is an osteoconductive biomaterial shown to be compatible with MSCs. This is the first study comparing the attachment, growth kinetics, and osteogenic potential of two MS...
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