Spencer L. Bowen
Virginia Tech
Imaging phantomOpticsPhysicsCorrection for attenuationRadiologyPET-CTBiomedical engineeringIterative reconstructionField of viewArtificial intelligenceDead timeMaterials scienceMonte Carlo methodMedical physicsImage resolutionPositron emission tomographyBreast imagingRheumatoid arthritisWristPositron emission mammographyScannerMammographyNuclear medicineHigh resolutionMedical imagingComputer visionComputer scienceBreast cancerImage qualityResolution (electron density)MedicinePartial volumeDetector
23Publications
11H-index
483Citations
Publications 21
Newest
#1Harshali Bal (Siemens)H-Index: 3
#2Jackson W. Kiser (Carilion Clinic)H-Index: 2
Last. Spencer L. Bowen (UTSW: University of Texas Southwestern Medical Center)
view all 4 authors...
PURPOSE We aim to quantify differences between a new maximum likelihood (ML) background scaling (MLBS) algorithm and two conventional scatter scaling methods for clinical PET/CT. A common source of reduced image quantification with conventional scatter corrections is attributed to erroneous scaling of the initial scatter estimate to match acquired scattered events in the sinogram. MLBS may have performance advantages over conventional methods by using all available data intersecting the subject....
Source
#1Spencer L. BowenH-Index: 11
#2Niccolo FuinH-Index: 7
Last. Ciprian CatanaH-Index: 40
view all 4 authors...
: Attenuation correction for PET-MR systems continues to be a challenging problem, particularly for body regions outside the head. The simultaneous acquisition of transmission scan based μ-maps and MR images on integrated PET-MR systems may significantly increase the performance of and offer validation for new MR-based μ-map algorithms. For the Biograph mMR (Siemens Healthcare), however, use of conventional transmission schemes is not practical as the patient table and relatively small diameter ...
13 CitationsSource
#1Douglas N. Greve (Harvard University)H-Index: 64
#2David H. Salat (Harvard University)H-Index: 77
Last. Keith A. Johnson (Harvard University)H-Index: 134
view all 11 authors...
Abstract A cross-sectional group study of the effects of aging on brain metabolism as measured with 18F-FDG-PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Muller-Gartner (MG), and the symmetric geometric transfer matrix (SGTM) using 99 subjects aged 65–87 years from the Harvard Aging Brain study. Sensitivity to parameter selection was tested for MZ and MG. The various methods and parameter settings resulted in an extremely ...
116 CitationsSource
#1Ronald Borra (Harvard University)H-Index: 35
#2Hoonsung Cho (Chonnam National University)H-Index: 17
Last. Jacob M. Hooker (Harvard University)H-Index: 51
view all 10 authors...
Background: Simultaneous PET/MR imaging depends on MR-derived attenuation maps (mu-maps) for accurate attenuation correction of PET data. Currently, these maps are derived from gradient-echo-based MR sequences, which are sensitive to susceptibility changes. Iron oxide magnetic nanoparticles have been used in the measurement of blood volume, tumor microvasculature, tumor-associated macrophages, and characterizing lymph nodes. Our aim in this study was to assess whether the susceptibility effects ...
7 CitationsSource
#1Ciprian Catana (Harvard University)H-Index: 40
#2Daniel B. Chonde (MIT: Massachusetts Institute of Technology)H-Index: 17
Last. Joshua L. Roffman (Harvard University)H-Index: 41
view all 7 authors...
Our goal in this study was to characterize the combined effect of MR-assisted motion correction (MC) and partial volume effects correction (PVEC) on the estimation of [11C]NNC112 binding potential (BP) in healthy volunteers. 29 subjects were scanned on the Siemens 3T MR-BrainPET scanner prototype. Emission data were acquired in list mode format for 90-minutes following the i.v. administration of ~8 mCi of [11C]NNC112. The head attenuation map was obtained from the MPRAGE data using an atlas-base...
1 CitationsSource
#1Daniel B. Chonde (MIT: Massachusetts Institute of Technology)H-Index: 17
#2David Izquierdo-Garcia (Harvard University)H-Index: 30
Last. Ciprian Catana (Harvard University)H-Index: 40
view all 5 authors...
We describe a novel semi-automated pipeline which integrates advanced data analysis tools for MR and PET with advanced PET reconstruction correction methods (partial volume effect correction [PVC], motion correction [MC], attenuation correction [AC]) in a user-friendly Matlab graphical user interface (GUI). The reconstruction and analysis GUI is written in Matlab. Computationally intensive tasks in the pipeline are automatically transferred to a high-performance computing cluster and retrieved. ...
4 CitationsSource
#1Spencer L. BowenH-Index: 11
#2L.G. Byars (Siemens)H-Index: 11
Last. Ciprian CatanaH-Index: 40
view all 5 authors...
Kinetic parameters estimated from dynamic 18F-fluorodeoxyglucose (18F-FDG) PET acquisitions have been used frequently to assess brain function in humans. Neglecting partial volume correction (PVC) for a dynamic series has been shown to produce significant bias in model estimates. Accurate PVC requires a space-variant model describing the reconstructed image spatial point spread function (PSF) that accounts for resolution limitations, including non-uniformities across the field of view due to the...
17 CitationsSource
#1Spencer L. Bowen (Harvard University)H-Index: 11
#2Andrea Ferrero (UC Davis: University of California, Davis)H-Index: 8
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 3 authors...
Purpose: Dedicated breast PET/CT is expected to have utility in local staging, surgical planning, monitoring of therapy response, and detection of residual disease for breast cancer. Quantitative metrics will be integral to several such applications. The authors present a validation of fully 3D data correction schemes for a custom built dedicated breast PET/CT (DbPET/CT) scanner via 18F-FDG phantom scans. Methods: A component-based normalization was implemented, live-time was estimated with a mu...
11 CitationsSource
#1John M. Boone (UC Davis: University of California, Davis)H-Index: 74
#2Kai Yang (UC Davis: University of California, Davis)H-Index: 23
Last. Karen K. Lindfors (UC Davis: University of California, Davis)H-Index: 38
view all 8 authors...
Mammography has served the population of women who are at-risk for breast cancer well over the past 30 years. While mammography has undergone a number of changes as digital detector technology has advanced, other modalities such as computed tomography have experienced technological sophistication over this same time frame as well. The advent of large field of view flat panel detector systems enable the development of breast CT and several other niche CT applications, which rely on cone beam geom...
16 CitationsSource
#1Abhijit J. Chaudhari (UC Davis: University of California, Davis)H-Index: 18
#2Spencer L. Bowen (UC Davis: University of California, Davis)H-Index: 11
Last. Ramsey D. Badawi (UC Davis: University of California, Davis)H-Index: 29
view all 12 authors...
Eur J Nucl Med Mol Imaging (2010) 37:1047 DOI 10.1007/s00259-009-1364-x IMAGE OF THE MONTH High-resolution 18 F-FDG PET with MRI for monitoring response to treatment in rheumatoid arthritis Abhijit J. Chaudhari & Spencer L. Bowen & George W. Burkett & Nathan J. Packard & Felipe Godinez & Anand A. Joshi & Stanley M. Naguwa & David K. Shelton & John C. Hunter & John M. Boone & Michael H. Buonocore & Ramsey D. Badawi Received: 20 November 2009 / Accepted: 10 December 2009 / Published online: 30 Jan...
37 CitationsSource