Harry Openshaw
City of Hope National Medical Center
Internal medicineSurgeryPathologyOncologyAntigenMolecular biologyVirologyImmunologyVirusCyclophosphamideHematopoietic stem cell transplantationDiseaseImmunosuppressionMultiple sclerosisHerpes simplex virusTransplantationMedicineEncephalitisBiologyImmune systemGastroenterology
Publications 67
#1Richard A. NashH-Index: 71
#2George J. Hutton (BCM: Baylor College of Medicine)H-Index: 15
Last. James BowenH-Index: 28
view all 17 authors...
Objective: To evaluate the safety, efficacy, and durability of multiple sclerosis (MS) disease stabilization after high-dose immunosuppressive therapy (HDIT) and autologous hematopoietic cell transplantation (HCT). Methods: High-Dose Immunosuppression and Autologous Transplantation for Multiple Sclerosis (HALT-MS) is a phase II clinical trial of HDIT/HCT for patients with relapsing-remitting (RR) MS who experienced relapses with disability progression (Expanded Disability Status Scale [EDSS] 3.0...
82 CitationsSource
#1Richard A. NashH-Index: 71
#2George J. HuttonH-Index: 15
Last. James BowenH-Index: 28
view all 16 authors...
#1Harry Openshaw (City of Hope National Medical Center)H-Index: 29
#2Bihong T. Chen (City of Hope National Medical Center)H-Index: 4
1 CitationsSource
#1Chandran Ramakrishna (Beckman Research Institute)H-Index: 17
#2Adrianna Ferraioli (EVMS: Eastern Virginia Medical School)H-Index: 1
Last. Edouard M. Cantin (Beckman Research Institute)H-Index: 26
view all 8 authors...
The establishment of latent infections in sensory neurons is a remarkably effective immune evasion strategy that accounts for the widespread dissemination of life long Herpes Simplex Virus type 1 (HSV1) infections in humans. Periodic reactivation of latent virus results in asymptomatic shedding and transmission of HSV1 or recurrent disease that is usually mild but can be severe. An in-depth understanding of the mechanisms regulating the maintenance of latency and reactivation are essential for d...
20 CitationsSource
#1Richard A. NashH-Index: 71
#2George J. Hutton (BCM: Baylor College of Medicine)H-Index: 15
Last. George H. Kraft (UW: University of Washington)H-Index: 54
view all 19 authors...
Importance Most patients with relapsing-remitting (RR) multiple sclerosis (MS) who receive approved disease-modifying therapies experience breakthrough disease and accumulate neurologic disability. High-dose immunosuppressive therapy (HDIT) with autologous hematopoietic cell transplant (HCT) may, in contrast, induce sustained remissions in early MS. Objective To evaluate the safety, efficacy, and durability of MS disease stabilization through 3 years after HDIT/HCT. Design, Setting, and Particip...
129 CitationsSource
#1Mihaela C. Cristea (City of Hope National Medical Center)H-Index: 21
#2Saul E. RivkinH-Index: 46
Last. Robert J. Morgan (City of Hope National Medical Center)H-Index: 54
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ABSTRACT Aim: The primary objective was to determine maximum tolerated dose (MTD) and the potential PK advantage of IP nab-paclitaxel (favorable peritoneal cavity ratio of nab-paclitaxel: plasma). Methods: Phase I study of IP nab-paclitaxel, D1, 8, 15; 28-day cycle; 3 + 3 dose-escalation design in patients (pts) with advanced ovarian cancer primarily confined to the peritoneal cavity, unresponsive to previous regimens, or for which no standard regimens exist. Pts had pre-study IP catheters place...
#1Bihong T. ChenH-Index: 4
#2A. Orlando OrtizH-Index: 8
Last. Harry OpenshawH-Index: 29
view all 6 authors...
#1Linh M. Alejandro (City of Hope National Medical Center)H-Index: 1
Last. Stephen ShibataH-Index: 31
view all 5 authors...
Objectives:We sought to predict oxaliplatin-associated peripheral neuropathy during modified FOLFOX6 (mFOLFOX6) therapy.Methods:Equal numbers of male and female patients with previously untreated, primary or recurrent colorectal cancer were followed through a first course of mFOLFOX6 with 85 mg/m2 o
45 CitationsSource
#1Chandran Ramakrishna (City of Hope National Medical Center)H-Index: 3
#2Harry OpenshawH-Index: 29
Last. Edouard M. CantinH-Index: 26
view all 3 authors...
HSV encephalitis (HSE) is the most prevalent sporadic viral encephalitis. Although safe and effective antiviral therapies and greatly improved noninvasive diagnostic procedures have significantly improved outcomes, mortality (∼20%) and debilitating neurological sequelae in survivors remain unacceptably high. An encouraging new development is that the focus is now shifting away from the virus exclusively, to include consideration of the host immune response to infection in the pathology underlyin...
10 CitationsSource
#1Richard A. Nash (Fred Hutchinson Cancer Research Center)H-Index: 71
#2George J. Hutton (Baylor University)H-Index: 1
Last. James D. Bowen (UW: University of Washington)H-Index: 63
view all 19 authors...
3 CitationsSource