Young-Myeong Kim
Kangwon National University
EndocrinologyHippocampal formationMolecular biologyChemistryApoptosisNeuroprotectionOxidative stressNitric oxide synthaseGerbilAngiogenesisHippocampusReactive oxygen speciesCancer researchNitric oxideIschemiaBiochemistryMedicineBiologyCell biologyPharmacology
226Publications
44H-index
6,041Citations
Publications 276
Newest
#1Jaeseob Lee (Kangwon National University)H-Index: 1
#2Young-June Jin (MPG: Max Planck Society)H-Index: 4
Last. Hansoo Lee (Kangwon National University)H-Index: 36
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#1Bora Kim (Kangwon National University)H-Index: 4
#2Ji Hyeon Ahn (Kangwon National University)H-Index: 15
Last. Moo-Ho Won (Kangwon National University)H-Index: 44
view all 12 authors...
Altered expression levels of N‑methyl‑D‑aspartate receptor (NMDAR), a ligand‑gated ion channel, have a harmful effect on cellular survival. Hyperthermia is a proven risk factor of transient forebrain ischemia (tFI) and can cause extensive and severe brain damage associated with mortality. The objective of the present study was to investigate whether hyperthermic preconditioning affected NMDAR1 immunoreactivity associated with deterioration of neuronal function in the gerbil hippocampal CA1 regio...
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#1Songyi Park (Yonsei University)H-Index: 2
#2Ji Hoon Oh (Yonsei University)H-Index: 2
Last. Young Guen Kwon (Yonsei University)H-Index: 52
view all 11 authors...
Blocking the immune evasion mechanism of tumor cells has become an attractive means for treating cancers. However, the usage of a drug such as nivolumab (αPD-1), which blocks programmed cell death protein 1 (PD-1), turned out to be only effective against certain types of cancer. Especially, vascular abnormal structures of which deter delivery route by leakage and cause the poor perfusion were considered to be environment unfavorable to T cells and immune checkpoint blockade (ICB) delivery within...
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#1Tae-Kyeong Lee (Hallym University)H-Index: 11
#2Myoung Cheol Shin (Kangwon National University)H-Index: 8
Last. Choong Hyun Lee (DU: Dankook University)H-Index: 17
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It has been reported that CD200 (Cluster of Differentiation 200), expressed in neurons, regulates microglial activation in the central nervous system, and a decrease in CD200 expression causes an increase in microglial activation and neuronal loss. The aim of this study was to investigate time-dependent changes in CD200 expression in the hippocampus proper (CA1, 2, and 3 fields) after transient forebrain ischemia for 5 min in gerbils. In this study, 5-min ischemia evoked neuronal death (loss) of...
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#1Hyejin Sim (Kangwon National University)H-Index: 1
#2Tae-Kyeong Lee (Hallym University)H-Index: 11
Last. Moo-Ho Won (Kangwon National University)H-Index: 7
view all 16 authors...
Calbindin-D28k (CB), a calcium-binding protein, mediates diverse neuronal functions. In this study, adult gerbils were fed a normal diet (ND) or exposed to intermittent fasting (IF) for three months, and were randomly assigned to sham or ischemia operated groups. Ischemic injury was induced by transient forebrain ischemia for 5 min. Short-term memory was examined via passive avoidance test. CB expression was investigated in the Cornu Ammonis 1 (CA1) region of the hippocampus via western blot ana...
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#1Young-Eun Park (Kangwon National University)H-Index: 15
#2Yoohun Noh (CAU: Chung-Ang University)H-Index: 4
Last. Moo-Ho Won (Kangwon National University)H-Index: 44
view all 15 authors...
1 CitationsSource
#1Ah-Jun Lee (Kangwon National University)
#2Yeon-Ju Lee (Kangwon National University)H-Index: 5
Last. Kwon-Soo Ha (Kangwon National University)H-Index: 46
view all 9 authors...
Abstract Due to their short half-lives, repeated administration of anti-hyperglycemic drugs can cause pain, discomfort, tissue damage, and infection in diabetic patients. Therefore, there is a need to develop long-term drug delivery systems to treat diabetes and its complications. C-peptide can prevent diabetic complications, including diabetic vasculopathy, but its clinical application is limited by its short half-life. Here, we developed K9-C-peptide (human C-peptide conjugated to an elastin-l...
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#1Bora Kim (Kangwon National University)H-Index: 4
#2Tae-Kyeong Lee (Hallym University)H-Index: 11
Last. Joon Ha Park (Dongguk University)H-Index: 4
view all 15 authors...
1 CitationsSource
#1Tae-Kyeong Lee (Hallym University)H-Index: 11
#2Il-Jun Kang (Hallym University)H-Index: 24
Last. Moo-Ho Won (Kangwon National University)H-Index: 44
view all 14 authors...
Chlorogenic acid (CGA), an ester of caffeic acid and quinic acid, is among the phenolic acid compounds which can be naturally found in green coffee extract and tea. CGA has been studied since it displays significant pharmacological properties. The aim of this study was to investigate the effects of CGA on cognitive function and neuroprotection including its mechanisms in the hippocampus following transient forebrain ischemia in gerbils. Memory and learning following the ischemia was investigated...
7 CitationsSource
#1Jae-Ah Seo (Kangwon National University)H-Index: 1
#2Hye-Yoon Jeon (Kangwon National University)H-Index: 6
Last. Kwon-Soo Ha (Kangwon National University)H-Index: 46
view all 9 authors...
Abstract Midazolam is an anesthetic agent commonly used for anesthesia and sedation in surgery. However, there is no information on the role of midazolam in hyperglycemia-induced cancer metastasis to date. In this study, we investigated the effects of midazolam on inhibiting metastases in the lungs of diabetic mice and on human pulmonary microvascular endothelial cells (HPMVECs). Subcutaneous injection of midazolam inhibited hyperglycemia-induced cancer metastasis in the lungs of diabetic mice. ...
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