Anne Marie Lennon
Johns Hopkins University School of Medicine
CancerInternal medicineRadiologySurgeryPathologyOncologyRetrospective cohort studyDysplasiaPancreatitisPancreatic cystsIntraductal papillary mucinous neoplasmAcute pancreatitisCarcinomaStentPancreasPancreatic cancerEndoscopic ultrasoundCystIn patientGeneral surgeryMedicineGastroenterology
Publications 250
#1Kohei Fujikura (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
#1Kohei Fujikura (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 3
Last. Laura D. Wood (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 57
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Objective Intraductal papillary mucinous neoplasms (IPMNs) are non-invasive precursor lesions that can progress to invasive pancreatic cancer and are classified as low-grade or high-grade based on the morphology of the neoplastic epithelium. We aimed to compare genetic alterations in low-grade and high-grade regions of the same IPMN in order to identify molecular alterations underlying neoplastic progression. Design We performed multiregion whole exome sequencing on tissue samples from 17 IPMNs ...
7 CitationsSource
#1Jorge D. MachicadoH-Index: 13
#2Bertrand NapoleonH-Index: 28
Last. Somashekar G. KrishnaH-Index: 21
view all 17 authors...
#1Jorge D. Machicado (Mayo Clinic)H-Index: 13
#2Bertrand NapoleonH-Index: 28
Last. Somashekar G. Krishna (OSU: Ohio State University)H-Index: 21
view all 17 authors...
#1Rui Wang (Sichuan University)H-Index: 2
#2Sonmoon Mohapatra (Johns Hopkins University)
Last. Saowanee Ngamruengphong (Johns Hopkins University)H-Index: 31
view all 14 authors...
Background and Aims Endoscopic therapy (ET) has been used to treat nonampullary duodenal neuroendocrine tumors (NAD-NETs) ≤10 mm in size, but data on long-term outcomes are limited. In addition, management of 11- to 19-mm NAD-NETs is not well defined because of variable estimates of risk of metastasis. We aimed to determine the prevalence and risk factors of metastasis of NAD-NETs ≤19 mm and evaluate the long-term survival of patients after ET as compared with radical surgery. Methods The Survei...
2 CitationsSource
#1Mohamad DboukH-Index: 6
Last. Marcia I. CantoH-Index: 73
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Abstract Background /Objectives: Pancreatic cysts are frequently detected in high-risk individuals (HRI) undergoing surveillance for pancreatic cancer. The International Cancer of the Pancreas Screening (CAPS) Consortium developed consensus recommendations for surgical resection of pancreatic cysts in HRI that are similar to the Fukuoka guidelines used for the management of sporadic cysts. We compared the performance characteristics of CAPS criteria for pancreatic cyst management in HRI with the...
#1Ding Ding (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 51
#2Ammar A. Javed (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 23
Last. Daniel A. Laheru (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 24
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Recent research on genomic profiling of pancreatic ductal adenocarcinoma (PDAC) has identified many potentially actionable alterations. However, the feasibility of using genomic profiling to guide routine clinical decision making for PDAC patients remains unclear. We retrospectively reviewed PDAC patients between October 2013 and December 2017, who underwent treatment at the Johns Hopkins Hospital and had clinical tumor next-generation sequencing (NGS) through commercial resources. Ninety-two pa...
1 CitationsSource
#1Shiro Kohi (Johns Hopkins University)H-Index: 2
#2Anne Macgregor-Das (Johns Hopkins University)H-Index: 11
Last. Michael Goggins (Johns Hopkins University)H-Index: 118
view all 11 authors...
ABSTRACT Background & Aims The tumor microbiome of patients with pancreas ductal adenocarcinoma (PDAC) includes bacteria normally present in the upper gastrointestinal tract. If the predominant source of intratumoral bacteria in patients with PDAC is retrograde migration from the duodenum, duodenal fluid could be a representative biospecimen for determining microbiome profiles of patients with PDAC or at risk of developing PDAC. Methods We performed a case-control study comparing bacterial and f...
1 CitationsSource
#1Anne Marie Lennon (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 43
#2Adam H. BuchananH-Index: 22
Last. Nickolas PapadopoulosH-Index: 26
view all 40 authors...
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multi-cancer blood testing coupled with PET-CT imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) we...
96 CitationsSource