Ling Qin
The Chinese University of Hong Kong
AnatomyEndocrinologyBiomedical engineeringSurgeryPathologyBone remodelingChemistryMaterials scienceIn vivoOsteoporosisBone mineralQuantitative computed tomographyBone densityTendonCartilageCortical boneBone resorptionOrthopedic surgeryMedicineBone healing
622Publications
58H-index
12.5kCitations
Publications 610
Newest
#1Peng Wan (CUHK: The Chinese University of Hong Kong)
#2Weidan Wang (DUT: Dalian University of Technology)
Last. Ke Yang (CAS: Chinese Academy of Sciences)H-Index: 42
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Abstract Osteoporotic fracture with increase of aging population became an urgent orthopedic problem. Bisphosphonates were widely recommended as effective clinical treatment drugs. Combination of biodegradable Mg-based implants and merits of bisphosphonates was suggested for osteoporotic fracture healing. Considering the mild and sustained drug release, a novel one-step electrodeposition synthesis of drug loaded coating was proposed in this study. In comparison to conventional soaking method, en...
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#1Hao Yao (CUHK: The Chinese University of Hong Kong)H-Index: 3
#2Jiankun Xu (CUHK: The Chinese University of Hong Kong)H-Index: 10
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 16 authors...
Abstract Introduction We previously demonstrated that magnesium ions (Mg2+) was a novel therapeutic alternative for osteoarthritis (OA) through promoting the hypoxia inducible factor-1α (HIF-1α)-mediated cartilage matrix synthesis. However, oxidative stress can inhibit the expression of HIF-1α, amplify the inflammation that potentially impairs the therapeutic efficacy of Mg2+ in OA. Vitamin (VC), a potent antioxidant, may enhance the efficacy of Mg2+ in OA treatment. This study aims to investiga...
2 CitationsSource
#1Yang Liu (PKU: Peking University)
#1Yang Liu (PKU: Peking University)H-Index: 3
Last. Yufeng Zheng (PKU: Peking University)H-Index: 70
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Abstract Biodegradable metals have great attraction to become orthopaedic implants. Here, we demonstrated a biodegradable magnesium alloy incorporated with essential element sodium through Sn-Na master alloying technique. The designed MgSnZnNa alloy presented better hardness and corrosion resistance due to the uniform distribution of Na in Mg2Sn second phase and solid soluble Zn in Mg matrix. The co-release of Mg and Na ions resulted in advanced upregulation of osterix and osteocalcin expression...
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#1Tiev Miller (PolyU: Hong Kong Polytechnic University)H-Index: 2
#2Michael Ying (PolyU: Hong Kong Polytechnic University)H-Index: 31
Last. Marco Yiu Chung Pang (PolyU: Hong Kong Polytechnic University)H-Index: 35
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Abstract Bone health is often compromised after stroke and the distal radius is a common site of fragility fractures. The macro- and mircoproperties of bone tissue after stroke and their clinical correlates are understudied. The objectives of the study were to use High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT) to investigate the bone properties at the distal radius, and to identify the correlates of estimated failure load for the distal radius in people with chronic stroke...
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#1Haiyue Zu (CUHK: The Chinese University of Hong Kong)H-Index: 1
#2Kelvin ChauH-Index: 1
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 21 authors...
Abstract In this study, perforated cannulated magnesium (Mg) hip stents were fabricated via modified Mg injection molding and conventional machining, respectively. Additionally, the stent canal was filled with paraffin to simulate injection of biomaterials. The microstructure, mechanical performance, corrosion behavior, and biocompatibility were comparably studied. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) showed higher affinity of interstitial element such as o...
4 CitationsSource
#1Xuan He (CUHK: The Chinese University of Hong Kong)H-Index: 2
#2Ye Li (CUHK: The Chinese University of Hong Kong)H-Index: 5
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 9 authors...
Abstract Anterior cruciate ligament (ACL) reconstruction is the recommended treatment for ACL tear in the American Academy of Orthopaedic Surgeons (AAOS) guideline. However, not a small number of cases failed because of the tunnel bone resorption, unsatisfactory bone-tendon integration, and graft degeneration. The biomaterials developed and designed for improving ACL reconstruction have been investigated for decades. According to the Food and Drug Administration (FDA) and the International Organ...
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#1Jiali Wang (CUHK: The Chinese University of Hong Kong)H-Index: 15
#2Jiankun Xu (CUHK: The Chinese University of Hong Kong)H-Index: 10
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 13 authors...
Source
#1Xiangbo MengH-Index: 2
#2Sibylle GradH-Index: 37
Last. Xinluan WangH-Index: 25
view all 7 authors...
Abstract Background Osteochondral defects (OCD) are common in osteoarthritis (OA) and difficult to heal. Numerous tissue engineering approaches and novel biomaterials are developed to solve this challenging condition. Although most of the novel methods can successfully treat osteochondral defects in preclinical trials, their clinical application in OA patients is not satisfactory, due to a high spontaneous recovery rate of many preclinical animal models by ignoring the inflammatory environment. ...
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#1Jie Mi (CUHK: The Chinese University of Hong Kong)H-Index: 1
#1Jie Mi (CUHK: The Chinese University of Hong Kong)H-Index: 2
Last. Ling Qin (CUHK: The Chinese University of Hong Kong)H-Index: 58
view all 13 authors...
Distraction osteogenesis (DO) is a well-established surgical technique for treating bone defect and limb lengthening. The major drawback of DO is the long treatment period as the external fixator h...
3 CitationsSource
#1Zhengyuan Bao (CUHK: The Chinese University of Hong Kong)H-Index: 1
#2Can Cui (CUHK: The Chinese University of Hong Kong)H-Index: 1
Last. Wing-Hoi Cheung (CUHK: The Chinese University of Hong Kong)H-Index: 28
view all 6 authors...
Sarcopenia is an ageing process with a decline of skeletal muscle mass and function, which is a challenging public health problem with reduced quality of life in patients. The endplate, the post-synaptic part of the neuromuscular junction (NMJ), occupies 0.1% of the myofiber surface area only, but is composed of millions of acetylcholine receptors (AChRs) that are efficient in binding to acetylcholine (ACh) and triggering skeletal muscle contraction. This systematic review aims to examine ageing...
1 CitationsSource
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