Zengfa Huang
Huazhong University of Science and Technology
CellAlkaline phosphataseChemistryMesenchymal stem cellRUNX2OsteoporosisBone mineralOsteopeniaOsteosarcomaCoronary artery diseaseOsteoblastIcariinCortical boneChondroblastic OsteosarcomaBone morphogenetic protein 2Cancer researchCell growthMedicineBiologyCell biology
8Publications
4H-index
48Citations
Publications 8
Newest
#1Zengfa Huang (HUST: Huazhong University of Science and Technology)H-Index: 4
#2Hui Wei (Nanjing Medical University)H-Index: 1
Last. Shutong Zhang (HUST: Huazhong University of Science and Technology)H-Index: 4
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Increasing research has demonstrated that expression of brain and muscle ARNTlike 1 (BMAL1) and other circadian clock genes can be regulated by drugs and toxicants. We previously demonstrated that icariin, extracted from Herba Epimedii, sromotes osteogenic differentiation. However, the mechanism underlying the association between icariin and BMAL1 in osteogenic differentiation of bone marrowderived mesenchymal stem cells (BMSCs) remains unclear. The present study was designed with an aim to clar...
2 CitationsSource
#1Zengfa Huang (HUST: Huazhong University of Science and Technology)H-Index: 4
#2Jianwei Xiao (HUST: Huazhong University of Science and Technology)H-Index: 2
Last. Xiang Wang (HUST: Huazhong University of Science and Technology)H-Index: 5
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BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is a common abnormality among patients in T2DM. AIMS: We aimed to evaluate the feasibility of coronary computed tomography angiography (CCTA) for the assessment of LVDD in type 2 diabetes mellitus (T2DM) patients. METHODS: 80 consecutive T2DM patients who were referred for a clinically dual-source CCTA examination to evaluate suspected coronary artery disease and also underwent 2D echocardiography within 7 days of CCTA inclusion and exclu...
1 CitationsSource
#1Zengfa Huang (HUST: Huazhong University of Science and Technology)H-Index: 4
#2Cheng Cheng (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Xiang Wang (HUST: Huazhong University of Science and Technology)H-Index: 2
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: Osteoporosis has become one of the most serious public health problems. Icariin, miR-153 and Runt-related transcription factor 2 (Runx2) have been demonstrated to regulate cell proliferation and differentiation in multiple cells. The aim of the present experiments was to investigate the potential mechanism underlying osteoblast differentiation and cell proliferation of MC3T3-E1 cells treated with icariin. Cell Counting kit-8, alkaline phosphatase (ALP) activity and alizarin red S assays, as we...
11 CitationsSource
#1Zengfa Huang (HUST: Huazhong University of Science and Technology)H-Index: 4
#2Cheng Cheng (HUST: Huazhong University of Science and Technology)H-Index: 4
Last. Xiang Wang (HUST: Huazhong University of Science and Technology)H-Index: 2
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BACKGROUND/AIMS: Glucocorticoid (GC)-related osteonecrosis of the femoral head (ONFH) is a common complication following administration of steroids to treat many diseases. Our previous study demonstrated that icariin (ICA) might have a beneficial effect on the bone marrow mesenchymal stem cells (BMSCs) of patients with steroid-associated osteonecrosis. In this study, we investigated the underlying mechanisms of ICA associated with the potential enhancement of osteogenesis and anti-adipogenesis i...
20 CitationsSource
#1Zengfa HuangH-Index: 4
#2Xianzhe LiuH-Index: 15
Last. Xianzhe Liu (HUST: Huazhong University of Science and Technology)H-Index: 1
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OBJECTIVE: Osteoporosis is the well-known major complication in chronic hepatitis B virus (HBV) infection. Fewer reports are available of the relationship between bone loss and chronic HBV infection. We investigated the bone mineral density (BMD) and prevalence of osteoporosis in chronic HBV patients in comparison with healthy subjects. METHODS: We assessed 148 chronic HBV patients and 148 age- and gender-matched healthy controls by dual energy X-ray absorptiometry (DEXA) for determination of BM...
8 CitationsSource
#1Zengfa HuangH-Index: 4
#2Cheng ChengH-Index: 4
Last. Shuhua YangH-Index: 25
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Background/Aims: This experimental study aimed to evaluate the effect of low-concentration phosphoric acid on the surface structure of cortical allografts.
4 CitationsSource
#1Yunlu LiuH-Index: 4
#2Xiaobo FengH-Index: 2
Last. Xianzhe LiuH-Index: 15
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Osteosarcoma has a well-recognized bimodal distribution, with the first peak in adolescence and another in the elderly age-group. The elderly patients have different clinical features and a poorer prognosis as compared to adolescents. To better understand the biological features of osteosarcoma in the elderly population, we established a new human osteosarcoma cell line from a 58-year-old man with primary chondroblastic osteosarcoma. After 6 months of continuous culture in vitro for over 50 pass...
4 CitationsSource
#1Yunlu Liu (HUST: Huazhong University of Science and Technology)H-Index: 4
#2Xiaobo Feng (HUST: Huazhong University of Science and Technology)H-Index: 6
Last. Xianzhe Liu (HUST: Huazhong University of Science and Technology)H-Index: 1
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