Masayuki Takeda
University of Yamanashi
Internal medicineRadiologyUrologyEndocrinologySurgeryReceptorUrinationChemistryInternational Prostate Symptom ScoreNocturiaUrinary incontinenceOveractive bladderLower urinary tract symptomsUrinary bladderCancer researchMedicineUrinary systemBiologyCell biologyPharmacology
Publications 393
#1Masaki YoshidaH-Index: 25
#2Masayuki Takeda (University of Yamanashi)H-Index: 36
Last. Kazuyoshi MinemuraH-Index: 2
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AIMS To examine the safety and efficacy of vibegron, a new β3-adrenoceptor agonist, in patients aged ≥65 years, with a focus on the effects on cardiovascular system and overactive bladder (OAB) symptoms. METHODS A post-hoc subgroup analysis was performed of a randomized, placebo-controlled, double-blind comparative phase 3 study of vibegron, including those assigned to receive either vibegron 50 mg (V50), vibegron 100 mg (V100), or placebo for 12 weeks. Subjects were stratified into two subgroup...
#8Masayuki Takeda (University of Yamanashi)H-Index: 36
#1Hiroshi ShimuraH-Index: 3
Last. Masayuki TakedaH-Index: 36
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#1Tatsuya Ihara (University of Yamanashi)H-Index: 6
#2Takahiko Mitsui (University of Yamanashi)H-Index: 23
Last. Masayuki Takeda (University of Yamanashi)H-Index: 36
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Abstract Objectives Nocturia is a major problem in geriatric patients. Clock genes regulate circadian bladder function and Piezo type mechanosensitive ion channel component 1 (Piezo1) that senses bladder fullness. We utilized WT and Clock mutant (ClockΔ19/Δ19: nocturia phenotype) mice to determine if the effects of GsMTx4, a Piezo1 inhibitor, is dependent on circadian Piezo1 expression in the bladder. Methods We compared voiding behavior in mice after the administration of vehicle, low dose, or ...
#1Shojiro KatohH-Index: 4
#2Srinivas K RaoH-Index: 27
Last. Samuel J. K. Abraham (University of Yamanashi)H-Index: 13
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BACKGROUND Buccal mucosal epithelial cells show promising application for various regenerative medicine approaches. In this study, we examined the feasibility of culturing rabbit and human buccal mucosal epithelial cells in a novel thermoreversible gelation polymer (TGP) scaffold, without feeder layers or other foreign proteins. METHODS & RESULTS The results of this 28-day in vitro culture, u sing the conventional technique (2D) and TGP (3D) showed that the epithelial cell morphology could be ma...
1 Citations
#1Hiroshi Shimura (University of Yamanashi)H-Index: 3
#2Yoshitaka KuwaharaH-Index: 4
Last. Masayuki Takeda (University of Yamanashi)H-Index: 36
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AIMS Postprostatectomy incontinence is a major complication of prostatectomy. Although pelvic floor muscle training can successfully treat postprostatectomy incontinence, evidence for how muscle movement affects continence recovery is lacking. We evaluated dynamic factors of prostatectomy patients using cine magnetic resonance imaging to identify risk factors for postprostatectomy incontinence and reveal the contribution of pelvic floor muscles to continence recovery. METHODS A total of 128 pros...
#1Takahiko Mitsui (University of Yamanashi)H-Index: 23
#2Atsuko Araki (Hokkaido University)H-Index: 27
Last. Reiko Kishi (Hokkaido University)H-Index: 62
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OBJECTIVES: The early detection and treatment of cryptorchidism are necessary to preserve male fertility. This study aimed to assess the effect of parents' occupational environment on the incidence of cryptorchidism in their sons. METHODS: The study enrolled 51,316 newborn males, whose mothers were recruited in the Japan Environment and Children's Study. We analyzed cryptorchidism incidence in male newborns according to 14 categories of occupations. We also analyzed the effect of the mother's oc...
2 CitationsSource
#1Mitsuharu YoshiyamaH-Index: 31
#2Hideki KobayashiH-Index: 9
Last. Isao ArakiH-Index: 23
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We conducted this study to examine whether acid-sensing ion channels (ASICs) are involved in the modulation of urinary bladder activity with or without intravesical irritation induced by acetic acid. All in vivo evaluations were conducted during continuous infusion cystometry in decerebrated unanesthetized female mice. During cystometry with a pH 6.3 saline infusion, an i.p. injection of 30 μmol/kg A-317567 (a potent, non-amiloride ASIC blocker) increased the intercontraction interval (ICI) by 3...
1 CitationsSource
#1Satoru Kira (University of Yamanashi)H-Index: 9
#2Takahiko Mitsui (University of Yamanashi)H-Index: 23
Last. Masayuki Takeda (University of Yamanashi)H-Index: 22
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Purpose To investigate the association between nocturia and urinary metabolites in elderly men using metabolomic analysis.
1 CitationsSource
#1Yoshifumi Kasai (University of Yamanashi)
#2Norifumi Sawada (University of Yamanashi)H-Index: 13
Last. Masayuki Takeda (University of Yamanashi)H-Index: 36
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Abstract Distant urethral metastasis of the castration-resistant prostate cancer (CRPC) is very rare. In this case report, we present a 69-year-old man who was first diagnosed prostate cancer from the sessile papillary tumor in the prostatic urethra which recurred after surgery and androgen deprivation therapy and finally treated with CyberKnife radiosurgery. There has been no recurrence for 50 months. To the best of our knowledge, there is no case of urethral metastasis of the CRPC successfully...