Richen Li
Texas A&M University
SonicationSelf-healing hydrogelsCytotoxicityMicelleSelectivityBiophysicsTransmission electron microscopyNanoparticleCopolymerMonomerNanotechnologyNanocarriersAqueous solutionChemistryPolymer chemistrySupramolecular assemblyMaterials scienceMetal ions in aqueous solutionIn vitroSide chainIn vivoCombinatorial chemistryBiocompatibilityPaclitaxelEthylene glycolCarboxylateFluorophoreDrug deliverySilver acetateEthylenediamineChemical engineeringPolymerizationAntimicrobialPolymerAmphiphileFluorescenceHydrolysisPharmacology
24Publications
15H-index
490Citations
Publications 24
Newest
#1Yue Song (A&M: Texas A&M University)H-Index: 6
#2Mahmoud Elsabahy (A&M: Texas A&M University)H-Index: 28
Last. Lu Su (A&M: Texas A&M University)H-Index: 13
view all 14 authors...
Platelet-like and cylindrical nanostructures from sugar-based polymers are designed to mimic the aspect ratio of bacteria and achieve uroepithelial cell binding and internalization, thereby improving their potential for local treatment of recurrent urinary tract infections. Polymer nanostructures, derived from amphiphilic block polymers composed of zwitterionic poly(d-glucose carbonate) and semicrystalline poly(l-lactide) segments, were constructed with morphologies that could be tuned to enhanc...
1 CitationsSource
#1Yen-Nan Lin (A&M: Texas A&M University)H-Index: 6
#2Mahmoud Elsabahy (Assiut University)H-Index: 28
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 11 authors...
Biomimetic-cell-membrane-camouflaged polymeric nanocarriers, possessing advantages related to the functional diversity of natural cell membranes and the physicochemical tailorability of synthetic p...
5 CitationsSource
#1Richen Li (A&M: Texas A&M University)H-Index: 15
#2Hai Wang (A&M: Texas A&M University)H-Index: 11
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 12 authors...
As a rapid, controllable, and easily transferrable approach to the preparation of antimicrobial nanoparticle systems, a one-step, light-driven procedure was developed to produce asymmetric hybrid inorganic–organic nanoparticles (NPs) directly from a homogeneous Ag/polymer mixture. An amphiphilic triblock polymer was designed and synthesized to build biocompatible NPs, consisting of poly(ethylene oxide) (PEO), carboxylic acid-functionalized polyphosphoester (PPE), and poly(l-lactide) (PLLA). Unex...
9 CitationsSource
#1Gyu Seong Heo (WashU: Washington University in St. Louis)H-Index: 14
#2Yongfeng Zhao (JSU: Jackson State University)H-Index: 12
Last. Yongjian Liu (WashU: Washington University in St. Louis)H-Index: 4
view all 20 authors...
Nanoparticles have been widely used for preclinical cancer imaging. However, their successful clinical translation is largely hampered by potential toxicity, unsatisfactory detection of malignancy at early stages, inaccurate diagnosis of tumor biomarkers, and histology for imaging-guided treatment. Herein, a targeted copper nanocluster (CuNC) is reported with high potential to address these challenges for future translation. Its ultrasmall structure enables efficient renal/bowel clearance, minim...
20 CitationsSource
#1Mei Dong (A&M: Texas A&M University)H-Index: 7
#2Michiel G. Wessels (UD: University of Delaware)H-Index: 4
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 13 authors...
In this work, we investigated the fundamental molecular parameters that guide the supramolecular assembly of glucose-based amphiphilic coil–brush block polymers in aqueous solution and elucidated architecture–morphology relationships through experimental and simulation tools. Well-defined coil–brush polymers were synthesized through ring-opening polymerizations (ROP) of glucose carbonates to afford norbornenyl-functionalized poly(glucose carbonate) (NB-PGC) macromonomers, followed by sequential ...
9 CitationsSource
#1Qingquan Chen (Texas A&M Health Science Center)H-Index: 4
#2Kush N. Shah (Texas A&M Health Science Center)H-Index: 6
Last. Carolyn L. Cannon (Texas A&M Health Science Center)H-Index: 32
view all 9 authors...
Pseudomonas aeruginosa has been detected in the lungs of ∼50% of patients with cystic fibrosis (CF), including 20% of adult CF patients. The majority of these adult patients harbor multi-drug resistant (MDR) strains, limiting the available treatment options. Silver has long been used as a broad-spectrum antimicrobial agent with a low incidence of resistance. Despite low toxicity, poor availability of silver cations mandates a high dosage to effectively eradicate infections. To address this short...
11 CitationsSource
#1Richen Li (A&M: Texas A&M University)H-Index: 15
#2Mahmoud Elsabahy (Assiut University)H-Index: 28
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 11 authors...
A zwitterionic polyphosphoester (zPPE), specifically l-cysteine-functionalized poly(but-3-yn-1-yloxy)-2-oxo-1,3,2-dioxaphospholane (zPBYP), has been developed as a poly(ethylene glycol) (PEG) alternative coating material for gold nanoparticles (AuNPs), the most extensively investigated metal nanoparticulate platform toward molecular imaging, photothermal therapy, and drug delivery applications. Thiol–yne conjugation of cysteine transformed an initial azido-terminated and alkynyl-functionalized P...
4 CitationsSource
#1Yen-Nan Lin (A&M: Texas A&M University)H-Index: 6
#2Lu Su (A&M: Texas A&M University)H-Index: 13
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 8 authors...
The development of next-generation smart nanocarriers that can be tailored for specific applications requires precise control over physiochemical properties, yet modulation of nanostructures solely through synthetic routes is a time-consuming and labor-intensive process. In this work, co-assembly of two degradable glucose-based amphiphilic block polymers is demonstrated as a means to control nanoparticle size, surface charge, and stimuli-responsive properties, allowing optimization of these cons...
4 CitationsSource
#1Yue SongH-Index: 6
#2Xiaozhou JiH-Index: 7
Last. Karen L. WooleyH-Index: 100
view all 7 authors...
Fundamental studies that gain an understanding of the tunability of physical properties of natural product-based polymers are vital for optimizing their performance in extensive applications. Variation of glass transition temperature (Tg) was studied as a function of the side chain structure and molar mass for linear poly(glucose carbonate)s. A remarkable range of Tg values, from 38 to 125 °C, was accomplished with six different alkyloxycarbonyl side chains. The impact of molar mass on Tg was in...
14 CitationsSource
#1Hai Wang (A&M: Texas A&M University)H-Index: 11
#2Mei Dong (A&M: Texas A&M University)H-Index: 7
Last. Karen L. Wooley (A&M: Texas A&M University)H-Index: 100
view all 11 authors...
Camptothecin (CPT) is a promising anticancer drug, yet its therapeutic potential has been limited by poor water solubility and facile hydrolysis of the lactone form into an inactive carboxylate form at neutral pH. In this work, a fundamental synthetic methodology was advanced to allow for the preparation of well-defined functional polyphosphoramidate (PPA)-based block copolymers that coassembled with CPT into nanoparticles, which underwent coincident acid-triggered polymer backbone degradation, ...
5 CitationsSource