Ryota Kawai
Daiichi Sankyo
GeneInternal medicineEndocrinologyUnfolded protein responseAntigenGene expressionMolecular biologyATF3AntibodyChemistryApoptosisToxicokineticsImmunologyIn vivoPrimary and secondary antibodiesMethemoglobinT cellKeyhole limpet hemocyaninCyclophosphamideMethemoglobinemiaCycloheximideKupffer cellCHOPHemocyaninImmunosuppressionImmunizationImmunoglobulin GSpleenGlutathione S-Transferase MuToxicityProgrammed cell deathGlutathioneMedicineProtein kinase BDose–response relationshipBiologyImmune system
7Publications
4H-index
49Citations
Publications 7
Newest
#1Ryota Kawai (Daiichi Sankyo)H-Index: 4
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Teruo Kawada (Kyoto University)H-Index: 64
view all 8 authors...
T-cell dependent antibody response (TDAR) incorporating both primary and secondary responses to keyhole limpet hemocyanin (KLH) in canine models have not yet been fully understood. To develop a practical dog TDAR model, we characterized primary and secondary antibody responses by intravenous or intramuscular immunization of KLH twice at intervals of 8 days during a 28-day course of study. Primary immunization with KLH by both routes induced a maximum IgM response on 6 to 8 days after the treatme...
6 CitationsSource
#1Ryota KawaiH-Index: 4
#2Shiho ItoH-Index: 1
Last. Teruo Kawada (Kyoto University)H-Index: 64
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To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary antibody responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during a 14-day course of study, a pattern closely linked to that of a short-term general toxicity study. Female rats of four representative strains (e.g., Sprague-Dawley, Wistar, Fischer, and Lewis) were immunized twice with intravenous administrations of KLH (300 µg/rat) on Days 5 and 9 during a 14-day treatme...
18 CitationsSource
#1Shingo Arakawa (Daiichi Sankyo)H-Index: 11
#2Takanori MaejimaH-Index: 6
Last. Wataru TakasakiH-Index: 14
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A specific substrate to Mu class glutathione S-transferase (GST), 1,2-dichloro-4-nitrobenzene (DCNB), was administered to mice with a disrupted GST Mu 1 gene (Gstm1-null mice) to investigate the in vivo role of murine Gstm1 in toxicological responses to DCNB. A single oral administration of DCNB at doses of 500 and 1000 mg/kg demonstrated a marked increase in blood methemoglobin (MetHB) in Gstm1-null mice but not in wild-type mice. Therefore, Gstm1-null mice were considered to be more predispose...
14 CitationsSource
#1Shingo ArakawaH-Index: 11
#2Takanori MaejimaH-Index: 6
Last. Wataru TakasakiH-Index: 14
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#1Kazuyoshi KumagaiH-Index: 7
#2Yosuke AndoH-Index: 17
Last. Munehiro TeranishiH-Index: 11
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C/EBP homologous protein (CHOP) is a transcriptional factor and is induced under conditions such as the unfolded protein response or amino acid starvation. A previous study showed that the transcriptional level of CHOP was highly increased in rat liver in which hepatocellular apoptosis was induced by cycloheximide (CHX) treatment. Here, we investigated the relationship between hepatocellular apoptosis and CHOP-mediated apoptotic pathway, and studied the mechanisms of induction of CHOP gene in th...
12 CitationsSource
#1Tetsuo AidaH-Index: 6
#2Ryota KawaiH-Index: 4
Last. Tadashi FurukawaH-Index: 8
view all 4 authors...