Kui Wang
Peking University
CytotoxicityBiophysicsEndocrinologyNuclear chemistryMembrane proteinCellInorganic chemistryChemistryApoptosisLanthanideVanadateCell cycleMembraneCalciumBiochemistryMAPK/ERK pathwayCell growthCrystallographyBiologyCell biology
Publications 96
#1Xin Pan (PKU: Peking University)H-Index: 1
#2Jinxia Li (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Siwang Yu (PKU: Peking University)H-Index: 29
view all 7 authors...
Prolonged exposure to gadolinium-based contrast agents has been reported to trigger nephrogenic systemic fibrosis in end stage renal disease patients. However, the exact molecular mechanisms are not fully understood, and no effective therapy is available to date. In the present study, we report that gadolinium chloride (Gd3+) concentration- and time-dependently promoted the proliferation of HEK293 human embryonic kidney cells by increasing DNA synthesis. Gd3+ treatment increased the protein leve...
1 CitationsSource
#1Yue Zhang (PKU: Peking University)H-Index: 3
#2Lichao Wang (PKU: Peking University)H-Index: 1
Last. Xiaoda Yang (PKU: Peking University)H-Index: 24
view all 5 authors...
Abstract Vanadium compounds have arisen as potential therapeutic agent for the treatment of cancers over the past decades. A few studies suggested that vanadyl complexes may discriminate between the cancerous and the normal cells. Here, we reported the investigation on the pro-apoptotic effect and the underlying mechanism of bis(acetylacetonato) oxovanadium(IV) ([VO(acac)2]) on SH-SY5Y neuroblastoma cells in comparison with that of mouse primary cortex neurons. The experimental results revealed ...
2 CitationsSource
#1Cai-xia Yu (PKU: Peking University)H-Index: 2
#2Jiao Gong (PKU: Peking University)H-Index: 1
Last. Kui Wang (PKU: Peking University)H-Index: 24
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Abstract Rat calvarial osteoblasts were treated with lanthanum chloride (LaCl 3 ) to explore its effect on the mineral crystalline phase during the process of osteoblast calcification in vitro . The results confirmed that La was readily deposited in the mineral component of the matrix. Employing high-resolution transmission electron microscopy and Fourier transform infrared microspectroscopy techniques, we demonstrated that features comparable to dicalcium phosphate dihydrate (DCPD) and octacalc...
3 CitationsSource
To analyze the results of syphilis specific serological tests among entry personnel in Beijing port during year 2012-2014 in order to provide evidence for the prevention and control of syphilis.Demographics data and syphilis specific test results of entry personnel were obtained from the information system of Beijing International Travel Healthcare Center and input into Excel 2016. Database for entry personnel was built up accordingly and was analyzed by IBM SPSS22.0.The number of entry personne...
#1Xiao-Gai YangH-Index: 11
#2Kui Wang (PKU: Peking University)H-Index: 24
4 CitationsSource
#1Xiao-rong Chen (PKU: Peking University)H-Index: 2
#2Jing Bai (PKU: Peking University)H-Index: 1
Last. Kui Wang (PKU: Peking University)H-Index: 24
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Abstract In the present study, we demonstrated that calcium phosphate (CaP) nanoparticles formed in cell culture media were implicated in the process of high inorganic phosphate (Pi) mediated osteogenic differentiation of rat bone marrow stromal cells (BMSCs). Exposure of BMSCs in vitro to high Pi-containing media reduced alkaline phosphatase (ALP) activity and the expressions of osteoblast-specific genes. The sediments of CaP nanoparticles were observed at the cell surface and some of them were...
14 CitationsSource
#1Kui WangH-Index: 24
#2Jian HuangH-Index: 12
Last. Xiao-rong ChenH-Index: 2
view all 5 authors...
#1Yue Zhang (PKU: Peking University)H-Index: 3
#2Qing Xia (PKU: Peking University)H-Index: 16
Last. Kui Wang (PKU: Peking University)H-Index: 24
view all 4 authors...
With the advance of aging, Alzheimer's disease (AD) is creating unsustainable challenges to healthcare and economy in China and worldwide. Recent researches demonstrated that the mechanism of AD involves a multiple of metabolic disorders, i.e. metallostasis, insulin resistance, neuroinflammation, alteration of mitochondria, and changes of blood brain barrier (BBB) function, linked with each other in the core mechanism of amyloid plaque and neurobrillary tangles (NFT). Strong evidences indicated ...
#1Jing-Cheng Liu (PKU: Peking University)H-Index: 2
#2You Yu (PKU: Peking University)H-Index: 1
Last. Xiao-Gai Yang (PKU: Peking University)H-Index: 11
view all 5 authors...
The increased plasma free fatty acid levels due to the deregulated lipolysis in adipocytes are considered as one of the major risk factors for developing type II diabetes. Vanadium compounds are well-known for their antidiabetic effects both on glucose and lipid metabolism, but the mechanisms are still not completely understood. The present study suggests a mechanism for how vanadium compounds exert antilipolytic effects. It demonstrates that all the three vanadium compounds, bis(acetylacetonato...
17 CitationsSource
#1Cong-Cong Hou (PKU: Peking University)H-Index: 1
#2Min Feng (PKU: Peking University)H-Index: 2
Last. Xiao-Gai Yang (PKU: Peking University)H-Index: 11
view all 4 authors...
Lanthanides are widely used in various fields for industrial, agricultural and medical purposes. They have also been used in Chinese agriculture either as fertilizers in plant production or as performance-enhancers in animal nutrition for many years. In view of their possible application for growth enhancing purposes and new medical applications, detailed information on how lanthanides influence physiological processes in biological systems is indispensable. In the present work, the effects of l...
6 CitationsSource
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