Bruno K. Podesser
Medical University of Vienna
Cardiac function curveInternal medicineEndocrinologyCardiac outputSurgeryPathologyCardiologyHemodynamicsChemistryIn vivoInflammationHeart failureCardiac surgeryReperfusion injuryAnesthesiaMyocardial infarctionNitric oxideIschemiaMedicinePharmacology
Publications 237
#1Matthias E. Sporer (Medical University of Vienna)H-Index: 4
#2Martin Aman (Medical University of Vienna)H-Index: 7
Last. Oskar C. Aszmann (Medical University of Vienna)H-Index: 32
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Clinically, peripheral nerve reconstructions in neonates are most frequently applied in brachial plexus birth injuries. Most surgical concepts, however, have investigated nerve reconstructions in adult animal models. The immature neuromuscular system reacts differently to the effects of nerve lesion and surgery and is poorly investigated due to the lack of reliable experimental models. Here, we describe an experimental forelimb model in the neonatal rat, to study these effects on both the periph...
#1Manuel Salzmann (Medical University of Vienna)H-Index: 10
#2Patrick Haider (Medical University of Vienna)H-Index: 3
Last. Philipp J. HohensinnerH-Index: 27
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Training of the innate immune system with orally ingested bacterial extracts was demonstrated to have beneficial effects on infection clearance and disease outcome. The aim of our study was to identify cellular and molecular processes responsible for these immunological benefits. We used a murine coronavirus (MCoV) A59 mouse model treated with the immune activating bacterial extract Broncho-Vaxom (BV) OM-85. Tissue samples were analysed with qPCR, RNA sequencing, histology, and flow cytometry. A...
Last. Thomas ReibergerH-Index: 40
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BACKGROUND & AIMS Liver fibrosis is the static and main (70-80%) component of portal hypertension (PH). We investigated dynamic components of PH by a 3-dimensional analysis based on correlation of hepatic collagen proportionate area (CPA) with portal pressure (PP) in animals or hepatic venous pressure gradient (HVPG) in patients. METHODS Different animal models (BDL: n=31, CCl4: n=12, TAA: n=12, CDHFD: n=12) and patients with a confirmed single etiology of cholestatic (PBC/PSC: n=16), alcohol re...
#1Ibrahim Aykac (Medical University of Vienna)H-Index: 1
#2Bruno K. Podesser (Medical University of Vienna)H-Index: 28
Last. Attila Kiss (Medical University of Vienna)H-Index: 14
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Diabetic patients are prone to suffer from cardiovascular disease, specifically from ischemic heart disease and diabetic cardiomyopathy, which have a huge impact on morbidity and mortality worldwide. Cardiac fibrosis due to alteration of the extracellular matrix (ECM) remodelling is often observed in diabetes and myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and death. At single-cell level, the ECM govern, metabolism, motility, orientation and prolife...
Post-ischemic left ventricular (LV) remodeling and its hypothetical prevention by repeated remote ischemic conditioning (rRIC) in male Sprague–Dawley rats were studied. Myocardial infarction (MI) was evoked by permanent ligation of the left anterior descending coronary artery (LAD), and myocardial characteristics were tested in the infarcted anterior and non-infarcted inferior LV regions four and/or six weeks later. rRIC was induced by three cycles of five-minute-long unilateral hind limb ischem...
#1Sarah Hochgeschurz (University of Veterinary Medicine Vienna)
#2Konstantin D. Bergmeister (Medical University of Vienna)H-Index: 10
Last. Anne-Margarete Kramer (Medical University of Vienna)
view all 13 authors...
#1Petra L. Szabo (Medical University of Vienna)H-Index: 3
#2Christopher Dostal (Medical University of Vienna)H-Index: 1
Last. Bruno K. Podesser (Medical University of Vienna)H-Index: 28
view all 11 authors...
Background:Vascular stiffness and endothelial dysfunction are accelerated by acute myocardial infarction (AMI) and subsequently increase the risk for recurrent coronary events.Aim:To explore whethe...
#1Nadine Maier (Medical University of Vienna)H-Index: 1
#2Constantin Gatterer (Medical University of Vienna)H-Index: 1
Last. Senta Graf (Medical University of Vienna)H-Index: 22
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Background: Fabry disease is a hereditary genetic defect resulting in reduced activity of the enzyme α-galactosidase-A and the accumulation of globotriaosylceramide (Gb3) in body fluids and cells. Gb3 accumulation was especially reported for the vascular endothelium in several organs. Methods: Three Fabry disease patients were screened using a micro-RNA screen. An in vitro approach in human endothelial cells was used to determine miRNA regulation by Gb3. Results: In a micro-RNA screen of three F...
#1Marjan EnayatiH-Index: 5
#2Karl H. SchneiderH-Index: 6
Last. Lubos Budinsky (STU: Slovak University of Technology in Bratislava)H-Index: 3
view all 16 authors...
Currently available synthetic small diameter vascular grafts reveal low patency rates due to thrombosis and intimal hyperplasia. Biofunctionalized grafts releasing nitric oxide (NO) in situ may overcome these limitations. In this study, a drug-eluting vascular graft was designed by blending polycaprolactone (PCL) with S-nitroso-human-serum-albumin (S-NO-HSA), a nitric oxide donor with prolonged half-life. PCL-S-NO-HSA grafts and patches were fabricated via electrospinning. The fabrication proces...
For large avians such as vultures, limb loss leads to loss of ambulation and eventually death from malnutrition. Prosthetic devices may replace the limb, however, conventional prosthetic sockets are not feasible in feathered limbs and the extreme stress and strain of unreflected daily use in animals. Osseointegration is a novel technique, where external prosthetic parts are connected directly to a bone anchor to provide a solid skeletal-attachment. This concept provides a high degree of embodime...
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