Hee-Je Kim
Catholic University of Korea
Internal medicineSurgeryOncologyImmunologyChemotherapyHematopoietic stem cell transplantationLeukemiaMyeloid leukemiaTotal body irradiationFludarabineGraft-versus-host diseaseBone marrowStem cellTransplantationIncidence (epidemiology)Cancer researchMedicineBiologyCumulative incidenceGastroenterology
370Publications
25H-index
2,405Citations
Publications 378
Newest
#1Jaewoong Lee (Catholic University of Korea)H-Index: 6
Last. Hee-Je Kim (Catholic University of Korea)H-Index: 25
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BCR-ABL1-positive acute leukemia can be classified into three disease categories: B-lymphoblastic leukemia (B-ALL), acute myeloid leukemia (AML), and mixed-phenotype acute leukemia (MPAL). We conducted an integrative analysis of RNA sequencing (RNA-seq) data obtained from 12 BCR-ABL1-positive B-ALL, AML and MPAL samples to evaluate its diagnostic utility. RNA-seq facilitated the identification of all p190 BCR-ABL1 with accurate splicing sites and a new gene fusion involving MAP2K2. Most of the c...
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#1Byung-Sik Cho (Catholic University of Korea)H-Index: 19
#2Gi-June Min (Catholic University of Korea)H-Index: 2
Last. Sung-Eun Lee (Catholic University of Korea)H-Index: 19
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Despite the proven efficacy of anti-T-cell or antithymocyte globulin (ATG) for chronic graft-versus-host disease (GVHD) prevention in transplantation from an unrelated donor, dosing protocols and the effects of ATG on relapse and infection remain controversial. In the setting of transplantation from an HLA-matched sibling (MSD-T), few randomized studies have been conducted. We conducted a prospective, single-center, open-label, randomized study of low-dose Thymoglobulin (2.5 mg/kg) for chronic G...
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#1Hartmut Döhner (University of Ulm)H-Index: 153
#2Argiris Symeonidis (University of Patras)H-Index: 29
Last. Hee-Je Kim (Catholic University of Korea)H-Index: 25
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In this phase 3 trial, older patients with acute myeloid leukemia ineligible for intensive chemotherapy were randomized 2:1 to receive the polo-like kinase inhibitor, volasertib (V; 350 mg intravenous on days 1 and 15 in 4-wk cycles), combined with low-dose cytarabine (LDAC; 20 mg subcutaneous, twice daily, days 1-10; n = 444), or LDAC plus placebo (P; n = 222). Primary endpoint was objective response rate (ORR); key secondary endpoint was overall survival (OS). Primary ORR analysis at recruitme...
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#1Haeyoun Choi (Catholic University of Korea)H-Index: 1
#2Yunkyung Lee (Catholic University of Korea)
Last. Tai-Gyu Kim (Catholic University of Korea)H-Index: 25
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Abstract null null Background aims null Immunotherapeutic approaches using γδ T cells have emerged as the function of γδ T cells in tumor surveillance and clearance has been discovered. In vitro expansion methods of γ9δ2 T cells have been based on phosphoantigens and cytokines, but expansion methods using feeder cells to generate larger numbers of γδ T cells have also been studied recently. However, there are no studies that directly compare γδ T cells cultured with phosphoantigens with those cu...
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#1Soojin Park (Catholic University of Korea)
#2Hee-Je Kim (Catholic University of Korea)H-Index: 25
Last. Areum HanH-Index: 14
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Background and objectives null The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M), a VEGFR-3 inhibiting chemical, was effectively restored the function of NK cells via the high expression of interferon- gamma (IFN-γ) in NK cells, as shown in our previous study. Although tremendous amount of clinical data using peptides are currently available in real clinic, pep...
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#1Byung-Sik Cho (Catholic University of Korea)H-Index: 19
#2Gi-June Min (Catholic University of Korea)H-Index: 2
Last. Ki-Seong Eom (Catholic University of Korea)H-Index: 18
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Given the controversies in the prognostic value of KIT mutations and optimal thresholds and time points of MRD monitoring for AML with CBFB-MYH11, we retrospectively evaluated 88 patients who underwent allogeneic hematopoietic stem cell transplantation (Allo-HSCT, n = 60) or autologous HSCT (Auto-HSCT, n = 28). The D816V KIT mutation was significantly associated with post-transplant relapse, contrasting with other types of mutations in KIT. Pre- and post-transplant (3 months after transplant) CB...
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#1Hee-Je Kim (Catholic University of Korea)H-Index: 25
#2Yonggoo Kim (Catholic University of Korea)H-Index: 21
Last. Byung-Sik Cho (Catholic University of Korea)H-Index: 19
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Given limited studies on next-generation sequencing-based measurable residual disease (NGS-MRD) in acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), we longitudinally collected samples before and after allo-HSCT from two independent prospective cohorts (n = 132) and investigated the prognostic impact of amplicon-based NGS assessment. Persistent mutations were detected pre-HSCT (43%) and 1 month after HSCT (post-HSCT-1m, 20%). All persiste...
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#1Byung-Sik Cho (Catholic University of Korea)H-Index: 19
#2Seung-Ah Yahng (Catholic University of Korea)H-Index: 16
Last. Hee-Je Kim (Catholic University of Korea)H-Index: 25
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BACKGROUND Allogeneic hematopoietic stem cell transplantation (HSCT) remains the most effective post-remission therapy conferring the chance of cure for acute myeloid leukemia (AML), including elderly patients. Although the number of transplants for elderly patients with AML (eAML) is increasing owing to greater availability of various graft sources together with the adoption of advanced supportive care and reduced-intensity conditioning (RIC) regimen, there are relatively limited data on the im...
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#8Silvia Park (Catholic University of Korea)H-Index: 6
Background Hemophagocytic lymphohistiocytosis (HLH) can be life-threatening if not detected and treated appropriately. The diagnosis of HLH can be confusing due to other similar febrile diseases that present with cytopenia. Natural-killer cell (NK)-cytotoxicity is an important diagnostic parameter for primary HLH; however, its role in secondary HLH in adults has not been well-elucidated. Methods We prospectively enrolled 123 adult patients with febrile conditions accompanied by cytopenia or marr...
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