Phil J. Greer
University of Pittsburgh
Internal medicineEndocrinologyMagnetic resonance imagingPsychologyCerebral blood flowBlood flowNeuroscienceProspective cohort studySerotoninPancreatitisAcute pancreatitisPancreasDepression (differential diagnoses)AltanserinHippocampusPrefrontal cortexNuclear medicine5-HT receptorDiabetes mellitusMedicineCohortBiologyGastroenterology
Publications 63
#1Ellyn K. Dunbar (University of Pittsburgh)H-Index: 1
#2Phil J. Greer (University of Pittsburgh)H-Index: 22
Last. Nalini M. GudaH-Index: 19
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INTRODUCTION: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are progressive inflammatory syndromes with variable features. Pain is the primary feature that contributes to low physical and mental quality of life with a third of patients reporting severe pain. Pain experience is worsened by depression. Here, we tested the hypothesis that genetic risk of the psychiatric conditions of anxiety and post-traumatic stress disorder (PTSD) is associated with pain in CP and RAP + CP subj...
2 CitationsSource
#1Christopher J. Langmead (CMU: Carnegie Mellon University)H-Index: 21
#2Peter Lee (HUP: Hospital of the University of Pennsylvania)H-Index: 9
Last. Georgios I. Papachristou (University of Pittsburgh)H-Index: 49
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INTRODUCTION Existing laboratory markers and clinical scoring systems have shown suboptimal accuracies for early prediction of persistent organ failure (POF) in acute pancreatitis (AP). We used information theory and machine learning to select the best-performing panel of circulating cytokines for predicting POF early in the disease course and performed verification of the cytokine panel's prognostic accuracy in an independent AP cohort. METHODS The derivation cohort included 60 subjects with AP...
#1Jorge D. MachicadoH-Index: 13
#2Rawad MounzerH-Index: 15
Last. Georgios I. PapachristouH-Index: 49
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#1Pedram Paragomi (University of Pittsburgh)H-Index: 11
#2Marie Tuft (University of Pittsburgh)H-Index: 4
Last. Georgios I. Papachristou (OSU: Ohio State University)H-Index: 49
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BACKGROUND AND AIM The primary aim was to validate the Pancreatitis Activity Scoring System (PASS) in a multicenter prospectively ascertained acute pancreatitis (AP) cohort. Second, we investigated the association of early PASS trajectories with disease severity and length of hospital stay (LOS). METHODS Data were prospectively collected through the APPRENTICE consortium (2015-2018). AP severity was categorized based on revised Atlanta classification. Delta PASS (ΔPASS) was calculated by subtrac...
INTRODUCTION Studies evaluating the natural history of exocrine pancreatic dysfunction (EPD) after acute pancreatitis (AP) are sparse. This study aims to assess incidence and predictors of weight loss and gastrointestinal (GI) symptoms suggestive of EPD 12 months after an AP episode. METHODS Patients enrolled in the Pancreatitis-associated Risk of Organ Failure Study at the time of an AP episode were included. Weight and GI symptom data were prospectively collected by self-report at enrollment a...
1 CitationsSource
#1Nicole L. Komara (University of Pittsburgh)H-Index: 1
#2Pedram Paragomi (University of Pittsburgh)H-Index: 11
Last. David C. Whitcomb (University of Pittsburgh)H-Index: 89
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Severe acute pancreatitis (SAP) includes persistent systemic inflammation (SIRS) and multiorgan failure (MOF). The mechanism of transition from SIRS to MOF is unclear. We developed a fluid compartment model and used clinical data to test predictions. The model includes vascular, interstitial and "third-space" compartments with variable permeability of plasma proteins at the capillaries. Consented patients from University of Pittsburgh Medical Center Presbyterian Hospital were studied. Preadmissi...
6 CitationsSource
#1Wei Zhan (University of Pittsburgh)H-Index: 1
#2Venkata S. Akshintala (Johns Hopkins University)H-Index: 15
Last. David C. Whitcomb (University of Pittsburgh)H-Index: 89
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Abstract Background Chronic pancreatitis (CP) is a complex inflammatory disorder of the pancreas affecting acinar cells, duct cells, islet cells and inflammatory cells including fibrosis-producing stellate cells. Serum trypsinogen is a biomarkers of acinar cell function. Aim To define the degree of correlation between low trypsinogen levels as a marker of acinar cell function and variable features of CP. Methods Serum samples from previously ascertained and well phenotyped case and control subje...
2 CitationsSource
#23Dhiraj Yadav (University of Pittsburgh)H-Index: 52
#24David C. Whitcomb (University of Pittsburgh)H-Index: 89
BACKGROUND Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associated genes are associated with a constant-severe pain experience in RAP/CP patients. STUDY A retrospective study was done using North American...
5 CitationsSource
#1Ellyn K. DunbarH-Index: 1
#2Phil J. GreerH-Index: 22
Last. David C. WhitcombH-Index: 89
view all 5 authors...