Alexander C. Egbe
Mayo Clinic
Internal medicineSurgeryCardiologyRetrospective cohort studyHemodynamicsHazard ratioHeart failureTetralogy of FallotVentricleAtrial fibrillationAortaHeart diseasePulmonary arteryPopulationIn patientIncidence (epidemiology)DiastoleMedicineCohortEjection fractionBlood pressure
187Publications
20H-index
1,417Citations
Publications 183
Newest
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Saraschandra Vallabhajosyula (Mayo Clinic)H-Index: 8
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 4 authors...
Abstract Background Lesion complexity and prosthetic valves are known risk factors for infective endocarditis in patients with congenital heart disease. Tetralogy of Fallot (TOF) is the most common complex/cyanotic congenital heart disease and often requires prosthetic valve implantation. Population-based risk of endocarditis in TOF patients is unknown. Methods We reviewed the National Inpatient Sample (NIS) and identified admissions in TOF patients (>18 years), 2000 to 2014. The primary outcome...
3 CitationsSource
#1William R. Miranda (Mayo Clinic)H-Index: 14
#2Barry A. Borlaug (Mayo Clinic)H-Index: 76
Last. Alexander C. Egbe (Mayo Clinic)H-Index: 20
view all 5 authors...
AIMS: The Fontan operation is associated with significant long-term morbidity and mortality, posing challenges in management. No haemodynamic classification has been established to aid management and prognostication of patients with Fontan palliation. Our aim was to assess haemodynamic profiles for Fontan patients and evaluate their relationships to prognosis. METHODS AND RESULTS: Eighty-four adult Fontan patients without obstruction or significant valve disease undergoing cardiac catheterizatio...
14 CitationsSource
#1H. Yang (UvA: University of Amsterdam)H-Index: 5
#2Gruschen R. Veldtman (Cincinnati Children's Hospital Medical Center)H-Index: 33
Last. Jamil Aboulhosn (UCLA: University of California, Los Angeles)H-Index: 27
view all 19 authors...
Background In Fontan patients with atrial arrhythmias (AA), non-vitamin K antagonist oral anticoagulants(NOACs) have a class III recommendation according to the Pediatric & Congenital Electrophysiology Society (PACES)/Heart Rhythm Society (HRS) guideline in 2014, due to lack of data on outcomes as opposed to evidence of harm. To address this gap in data, we investigated the safety and efficacy of NOACs in adults with a Fontan circulation in a worldwide study. Methods This is an international mul...
10 CitationsSource
#1Emmanuel Akintoye (WSU: Wayne State University)H-Index: 17
#2William R. Miranda (Mayo Clinic)H-Index: 14
Last. Alexander C. Egbe (Mayo Clinic)H-Index: 20
view all 5 authors...
Background National prevalence and outcomes of Fontan operation in the USA is unknown. Study objective was to determine trends (temporal change) in the annual volume of Fontan operations, in-hospital mortality, postoperative complications and type of hospital discharge. Methods Review of the Nationwide Inpatient Sample for patients that underwent Fontan operation from 2001 to 2014 using the International Classification of Diseases-Ninth Revision, Clinical Modification procedure code for Fontan o...
10 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Sindhura Ananthaneni (Mayo Clinic)H-Index: 4
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 12 authors...
BACKGROUND: There are limited data about outcomes of coronary artery disease (CAD) in adults with repaired tetralogy of Fallot (TOF). The purpose of this study was to describe the prevalence and treatment of CAD in adults with TOF, and the impact of CAD on long-term survival. METHODS: Retrospective review of MACHD database for adults with repaired TOF who underwent aortic root/selective coronary angiogram, 1990-2017. Patients were categorized into three groups: (1) No CAD defined as normal coron...
3 CitationsSource
#1William R. Miranda (Mayo Clinic)H-Index: 14
#2Donald J. Hagler (Mayo Clinic)H-Index: 88
Last. Nathaniel W. Taggart (Mayo Clinic)H-Index: 14
view all 7 authors...
OBJECTIVE: To review our experience with balloon testing prior to atrial septal defect (ASD) closure in adults with left ventricular (LV) diastolic dysfunction. BACKGROUND: ASD closure in patients with LV diastolic dysfunction may precipitate LV failure. Temporary ASD occlusion has been used in this scenario but data are limited. METHODS: Retrospective review of 27 patients age ≥ 50 years undergoing temporary ASD balloon occlusion between 2000 and 2018 for suspected LV diastolic dysfunction or e...
4 CitationsSource
Tetralogy of Fallot (TOF) patients remain at risk for cardiovascular events despite successful repair. Some of the current risk stratification tools require advanced imaging and invasive studies, and hence difficult to apply to routine patient care. A recent study showed that QRS fragmentation (QRS-
Source
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2William R. Miranda (Mayo Clinic)H-Index: 14
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 11 authors...
BACKGROUND: We hypothesized that echocardiographic indices of right ventricular to pulmonary artery (RV-PA) coupling were comparable to cardiac magnetic resonance imaging (CMRI)-derived RV volumetric indices in predicting disease severity in chronic pulmonary regurgitation (PR). METHODS: Patients with ≥ moderate PR (2003-2015) with and without prior CMRI scans were enrolled into the study cohort and validation cohort, respectively. Endpoint was to determine the association between noninvasive RV...
5 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2William R. Miranda (Mayo Clinic)H-Index: 14
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 9 authors...
Background Tachyarrhythmias and bradyarrhythmias affect 20%–50% of adult patients with tetralogy of Fallot (TOF) and some of these patients will require cardiac implantable electronic devices (CIED) such as pacemaker and/or internal cardioverter defibrillator. Methods The Mayo Adult Congenital Heart Disease database was queried for patients with repaired TOF and history of CIED implantation, 1990–2017. The study objectives were: (1) determine the occurrence of device-related complications define...
8 CitationsSource
#1Alexander C. Egbe (Mayo Clinic)H-Index: 20
#2Juan A. Crestanello (Mayo Clinic)H-Index: 26
Last. Heidi M. Connolly (Mayo Clinic)H-Index: 75
view all 4 authors...
Background Thoracic aortic aneurysm is common in patients with tetralogy of Fallot (TOF); the incidence of thoracic aortic dissection (TAD) is unknown, but generally considered to be uncommon. The ...
11 CitationsSource