Byung-Hee Chung
Kangwon National University
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#1Byung Hee Chung (Kangwon National University)H-Index: 3
#1Byung-Hee Chung (Kangwon National University)H-Index: 2
Last. Young-Myeong Kim (Kangwon National University)H-Index: 44
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We investigated the molecular effect and signal pathway of icariin, a major flavonoid of Epimedium koreanum Nakai, on angiogenesis. Icariin stimulated in vitro endothelial cell proliferation, migration, and tubulogenesis, which are typical phenomena of angiogenesis, as well as increased in vivo angiogenesis. Icariin activated the angiogenic signal modulators, ERK, phosphatidylinositol 3-kinase (PI3K), Akt, and endothelial nitric oxide synthase (eNOS), and increased NO production, without affecti...
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