Lizhi Zhang
Mayo Clinic
CancerInternal medicineRadiologyPathologyOncologyImmunohistochemistryBiopsyPancreatitisCarcinomaAutoimmune pancreatitisPancreasMetastasisPancreatic cancerEndoscopic ultrasoundAdenocarcinomaKRASCancer researchMedicineBiologyGastroenterology
Publications 138
#1Benjamin J. Van Treeck (Mayo Clinic)H-Index: 2
#2Surendra Dasari (Mayo Clinic)H-Index: 40
Last. Samar M. Said (Mayo Clinic)H-Index: 17
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OBJECTIVE To report the clinicopathologic and proteomic characteristics of a novel form of amyloidosis derived from the precursor protein somatostatin. MATERIALS AND METHODS Cases were identified by searching the Mayo Clinic amyloid liquid chromatography and tandem mass spectrometry (LC-MS/MS) typing database from 1 January 2008 to 1 September 2020 for specimens with the amyloid signature proteins and abundant somatostatin, in the absence of other amyloid precursor proteins. All available medica...
#1Daniel J. Rowan (University of Pittsburgh)
#2Saba YasirH-Index: 6
Last. Michael TorbensonH-Index: 82
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#1Antentor HintonH-Index: 1
#2Prasanna Katti (NIH: National Institutes of Health)H-Index: 4
Last. Rachel E. Geroux (Mayo Clinic)H-Index: 2
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Mitochondrial dynamics and morphology (fission, fusion, and the formation of nanotunnels) are very sensitive to the cellular environment and may be adversely affected by oxidative stress, changes in calcium levels, and hypoxia. Investigating the precise relationship between the organelle structure and function requires methods that can adequately preserve the structure while providing accurate, quantitative measurements of mitochondrial morphological attributes. Here, we demonstrate a practical ...
#1Yasuki Hori (Nagoya City University)H-Index: 13
#2Suresh T. Chari (Mayo Clinic)H-Index: 103
Last. Akira Satou (Aichi Medical University)H-Index: 8
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Biliary strictures caused by inflammation or fibrosis lead to jaundice and cholangitis which often make it difficult to distinguish malignant strictures. In cases when malignancy cannot be excluded, surgery is often performed. The concept of immunoglobulin G4 (IgG4)-related sclerosing cholangitis (SC) as a benign biliary stricture was recently proposed. The high prevalence of the disease in Asian countries has resulted in multiple diagnostic and treatment guidelines; however, there is need to fo...
#1Roman O. Kowalchuk (Mayo Clinic)
#2S.C. Lester (Mayo Clinic)H-Index: 4
Last. Kenneth W. Merrell (Mayo Clinic)H-Index: 11
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Background: We evaluated preoperative CA 19-9 levels in patients with resected pancreatic cancer to analyze whether they were predictive of clinical outcomes and could help select patients for additional therapy. We hypothesized that elevated CA 19-9 would be associated with worse pathologic findings and oncologic outcomes. Methods: This study assessed 509 patients with non-metastatic pancreatic adenocarcinoma who underwent resection at our institution from 1995-2011 and had preoperative CA 19-9...
1 CitationsSource
#1Shounak MajumderH-Index: 13
#2Rondell P. GrahamH-Index: 26
Last. John B. KisielH-Index: 22
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#1Daniel J. Rowan (Mayo Clinic)H-Index: 6
#2Lizhi Zhang (Mayo Clinic)H-Index: 54
Last. Valentina Logunova (Mayo Clinic)
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Pancreatic heterotopia most commonly occurs in the upper gastrointestinal tract, but can occur in other sites, including Meckel's diverticulum. When multiple histologic elements of the pancreatic tissue (acini, ducts, and endocrine cells) are present, the diagnosis is typically straightforward. In this article, we report a rare case of pure endocrine pancreatic heterotopia involving a Meckel's diverticulum, a potential mimic of a well-differentiated neuroendocrine tumor. Several features were us...
#1Ana Garcia Garcia de Paredes (University of Alcalá)
#2Rondell P. Graham (Mayo Clinic)H-Index: 26
Last. Ferga C. Gleeson (Mayo Clinic)H-Index: 28
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We read with great interest the recent articles by Luchini et al 1 2 and Grant et al 3 highlighting the low prevalence (1%–2%) of mismatch repair deficient pancreatic ductal adenocarcinoma (dMMR PDAC) and offering further knowledge pertaining to the molecular spectrum of this disease subtype. A plea was raised to augment translational and clinical research efforts to improve our understanding of dMMR PDAC. However, from a practical perspective, only 20% of patients with PDAC reach surgical oncol...
#1Yongchao LiH-Index: 1
#2Daniel J. Rowan (Mayo Clinic)H-Index: 6
Last. Lizhi ZhangH-Index: 54
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1 CitationsSource
#1Cody N. Rozeveld (Mayo Clinic)H-Index: 2
#2Katherine M. Johnson (Mayo Clinic)H-Index: 3
Last. Gina L. Razidlo (Mayo Clinic)H-Index: 12
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Oncogene-induced metabolic reprogramming is a hallmark of pancreatic cancer (PDAC), yet the metabolic drivers of metastasis are unclear. In PDAC, obesity and excess fatty acids accelerate tumor growth and increase metastasis. Here, we report that excess lipids, stored in organelles called lipid droplets (LD), are a key resource to fuel the energy-intensive process of metastasis. The oncogene KRAS controlled the storage and utilization of LD through regulation of hormone sensitive lipase (HSL), w...
15 CitationsSource