Laura R. Prakash
University of Texas MD Anderson Cancer Center
CancerInternal medicineRadiologySurgeryOncologyRetrospective cohort studyChemotherapyFOLFIRINOXNeoadjuvant therapyPancreatectomyPancreaticoduodenectomyPancreatic cancerGemcitabinePancreatic fistulaAdenocarcinomaPreoperative TherapyPancreatic ductal adenocarcinomaIn patientPerioperativeCancer researchMedicineGastroenterology
67Publications
15H-index
572Citations
Publications 75
Newest
Abstract null null Purpose null Patients with pancreatic cancer often receive radiation therapy before undergoing surgical resection. We compared the clinical outcomes differences between stereotactic body radiation therapy (SBRT) and 3-dimensional (3D)/intensity-modulated radiation therapy (IMRT). null null null Methods and Materials null We retrospectively collected data from the University of Texas MD Anderson Cancer Center. Patients with borderline resectable/potentially resectable or locall...
1 CitationsSource
#1Timothy E. NewhookH-Index: 13
#2Timothy J. VreelandH-Index: 11
Last. Michael J. OvermanH-Index: 59
view all 17 authors...
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#1Yi Tat Tong (University of Texas MD Anderson Cancer Center)
#2Hua Wang (University of Texas MD Anderson Cancer Center)H-Index: 48
Last. Robert A. Wolff (University of Texas MD Anderson Cancer Center)H-Index: 91
view all 13 authors...
Abstract null null Background null Glucose-regulated protein 78 (GRP78) plays an essential role in protein folding, transportation, and degradation, thus regulates ER homeostasis and promotes cell survival, proliferation and invasion. GRP78 expression in PDAC patients who received neoadjuvant therapy has not been reported. null null null Methods null This retrospective study of resected PDAC patients included 125 patients treated with neoadjuvant therapy (NAT) and 140 patients treated with surge...
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#1Timothy E. Newhook (University of Texas MD Anderson Cancer Center)H-Index: 13
#2Laura R. Prakash (University of Texas MD Anderson Cancer Center)H-Index: 15
Last. Jessica E. Maxwell (University of Texas MD Anderson Cancer Center)H-Index: 2
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BACKGROUND AND OBJECTIVES The impact of perioperative blood transfusion (PBT) on outcomes for pancreatic ductal adenocarcinoma (PDAC) patients given multimodality therapy (MMT) remains undefined. We sought to evaluate the association of PBT with survival after PDAC resection. METHODS Pancreatectomy patients (July 2011-December 2017) who received MMT were abstracted from a prospective database. Overall survival (OS) was compared by PBT within 30 days, 24 h (24HR-BT), or 24 h until 30 days (Postop...
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#1Chirayu Mohindroo (University of Texas MD Anderson Cancer Center)H-Index: 1
#2Merve Hasanov (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Robert A. Wolff (University of Texas MD Anderson Cancer Center)H-Index: 91
view all 18 authors...
Recent studies defined a potentially important role of the microbiome in modulating pancreatic ductal adenocarcinoma (PDAC) and responses to therapies. We hypothesized that antibiotic usage may predict outcomes in patients with PDAC. We retrospectively analyzed clinical data of patients with resectable or metastatic PDAC seen at MD Anderson Cancer from 2003 to 2017. Demographic, chemotherapy regimen and antibiotic use, duration, type, and reason for indication were recorded. A total of 580 patie...
2 CitationsSource
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#1Nathan H. Parker (University of Texas MD Anderson Cancer Center)H-Index: 16
#2Jessica Gorzelitz (UW: University of Wisconsin-Madison)H-Index: 3
Last. Matthew H.G. Katz (University of Texas MD Anderson Cancer Center)H-Index: 66
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Loss of skeletal muscle and inferior muscle quality are associated with poor prognosis in patients undergoing preoperative treatment for pancreatic cancer, so maintaining skeletal muscle health bef...
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#1Giampaolo Perri (University of Texas MD Anderson Cancer Center)H-Index: 9
#2Laura R. Prakash (University of Texas MD Anderson Cancer Center)H-Index: 15
Last. Matthew H.G. KatzH-Index: 66
view all 17 authors...
OBJECTIVE: We sought to identify potential radiologic and serologic markers of pancreatic tumor response to therapy, using pathologic major response (pMR) as the objective endpoint. BACKGROUND: We previously demonstrated that a pMR to preoperative therapy, defined as detection of <5% viable cancer cells in the surgical specimen on histopathological analysis, is an important prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Pretreatment and posttreatment comput...
29 CitationsSource
#1Jun Zhao (University of Texas MD Anderson Cancer Center)H-Index: 23
#2Luisa M. Solis Soto (University of Texas MD Anderson Cancer Center)H-Index: 5
Last. Huamin Wang (University of Texas MD Anderson Cancer Center)H-Index: 82
view all 13 authors...
BACKGROUND CD73, a newly recognized immune checkpoint mediator, is expressed in several types of malignancies. However, CD73 expression and its impact on tumor microenvironment and clinical outcomes in pancreatic ductal adenocarcinoma (PDAC) remain unclear. METHODS This study included two cohorts: 138 patients from our institution (MDA) and 176 patients from TCGA dataset. CD73 expression, CD4+, CD8+, CD21+ and CD45RO + tumor infiltrating lymphocytes (TILs) were evaluated by immunohistochemistry ...
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