Ryan A. Koppes
Northeastern University
Isometric exerciseAnatomySelf-healing hydrogelsNeuriteBiophysicsBiomedical engineeringNeuroscienceNanotechnologyChemistryMaterials scienceIn vivoStimulationSkeletal muscleJumpComputer scienceTissue engineeringOptogeneticsMyosinMedicineBiologyCell biology
61Publications
14H-index
1,032Citations
Publications 59
Newest
#1Adam J. Bindas (NU: Northeastern University)H-Index: 2
#2Subhash Kulkarni (Johns Hopkins University)H-Index: 14
Last. Abigail N. Koppes (NU: Northeastern University)H-Index: 13
view all 4 authors...
Abstract Parkinson's disease (PD) is a common neurodegenerative disease characterized by a progressive loss of fine motor function that impacts 1-2 out of 1,000 people. PD occurs predominately late in life and lacks a definitive biomarker for early detection. Recent cross-disciplinary progress has implicated the gut as a potential origin of PD pathogenesis. The gut-origin hypothesis has motivated research on gut PD pathology and transmission to the brain, especially during the prodromal stage (1...
Source
#1Max A Winkelman (NU: Northeastern University)H-Index: 1
#2Abigail N. Koppes (NU: Northeastern University)H-Index: 13
Last. Guohao Dai (NU: Northeastern University)H-Index: 28
view all 4 authors...
The ability of mammalian neural stem cells (NSCs) to self-renew and differentiate throughout adulthood has made them ideal to study neurogenesis and attractive candidates for neurodegenerative disease therapies. In the adult mammalian brain, NSCs are maintained in the neurovascular niche (NVN) where they are found near the specialized blood vessels, suggesting that brain endothelial cells (BECs) are prominent orchestrators of NSC fate. However, most of the current knowledge of the mammalian NVN ...
1 CitationsSource
#1David Diaz Vera (NU: Northeastern University)
#2Jonathan R. Soucy (NU: Northeastern University)H-Index: 5
Last. Abigail N. Koppes (NU: Northeastern University)H-Index: 13
view all 5 authors...
Abstract The expansion of optogenetics via the development and application of new opsins has opened a new world of possibilities as a research and therapeutic tool. Nevertheless, it has also raised questions about the innocuity of using light irradiation on tissues and cells such as those from the Peripheral Nervous System (PNS). Thus, to investigate the potential of PNS being affected by optogenetic light irradiation, rat dorsal root ganglion neurons and Schwann cells were isolated and their re...
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#1Daniel M. Ventre (NU: Northeastern University)H-Index: 2
#2Avery Cluff (NU: Northeastern University)
Last. Abigail N. Koppes (NU: Northeastern University)H-Index: 13
view all 6 authors...
Satisfactory treatment of peripheral nerve injury (PNI) faces difficulties owing to the intrinsic biological barriers in larger injuries and invasive surgical interventions. Injury gaps >3 cm have low chances of full motor and sensory recovery, and the unmet need for PNI repair techniques which increase the likelihood of functional recovery while limiting invasiveness motivate this work. Building upon prior work in ultrasound stimulation (US) of dorsal root ganglion (DRG) neurons, the effects of...
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#1Jonathan R. Soucy (NU: Northeastern University)H-Index: 5
#2Gabriel Burchett (NU: Northeastern University)H-Index: 1
Last. Ryan A. Koppes (NU: Northeastern University)H-Index: 14
view all 6 authors...
The transition to extrauterine life results in a critical surge of catecholamines necessary for increased cardiovascular, respiratory, and metabolic activity. The mechanisms mediating adrenomedullary catecholamine release are poorly understood, given the sympathetic adrenomedullary control systems9 functional immaturity. Important mechanistic insight is provided by newborns delivered by cesarean section or subjected to prenatal nicotine or opioid exposure, demonstrating the impaired release of a...
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#1Zachary J. Rogers (NU: Northeastern University)H-Index: 5
#2Michael P. Zeevi (NU: Northeastern University)H-Index: 1
Last. Sidi A. BencherifH-Index: 29
view all 4 authors...
Over the past decade, electroconductive hydrogels, integrating both the biomimetic attributes of hydrogels and the electrochemical properties of conductive materials, have gained significant attent...
2 CitationsSource
#1Jonathan R. SoucyH-Index: 5
#2Adam J. BindasH-Index: 2
Last. Ryan A. KoppesH-Index: 14
view all 9 authors...
Source
#1Jonathan R. Soucy (NU: Northeastern University)H-Index: 5
#2Adam J. Bindas (NU: Northeastern University)H-Index: 2
Last. Ryan A. Koppes (NU: Northeastern University)H-Index: 14
view all 9 authors...
Tissue-engineered models continue to experience challenges in delivering structural specificity, nutrient delivery, and heterogenous cellular components, especially for organ-systems that require functional inputs/outputs and have high metabolic requirements, such as the heart. While soft lithography has provided a means to recapitulate complex architectures in the dish, it is plagued with a number of prohibitive shortcomings. Here, concepts from microfluidics, tissue engineering, and layer-by-l...
1 CitationsSource
#1Tess Torregrosa (NU: Northeastern University)H-Index: 2
#2Sophie Webster (NU: Northeastern University)H-Index: 1
Last. Ryan A. Koppes (NU: Northeastern University)H-Index: 14
view all 8 authors...
Abstract Background Generally, primary neurons are isolated and seeded within hours of isolation, but cryopreservation, documented for a small number of central and peripheral neuronal subtypes, can contribute to improved utility and reduce the cost of developing new in vitro models. The preservation of cells of the autonomic nervous system (ANS), specifically sympathetic and parasympathetic neurons, has not been explored. New Method In this work, we establish a method for preserving cardiac ANS...
1 CitationsSource
#1Sanjin HosicH-Index: 3
#2Will LakeH-Index: 1
Last. Abigail N. KoppesH-Index: 13
view all 7 authors...
The intestinal epithelium contains specialized cells including enterocytes, goblet, Paneth, enteroendocrine, and stem cells. Impaired barrier integrity in Inflammatory Bowel Disease is characterized by elevated levels of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Prior studies in immortalized lines such as Caco-2, without native epithelial heterogeneity, demonstrate the amelioration of TNF-α compromised barrier integrity via nicotinic (nAChR) or muscarinic (mAChR)...
1 CitationsSource