Patrick W. O'Leary
Mayo Clinic
Internal medicineRadiologySurgeryCardiologyRetrospective cohort studyHemodynamicsPediatricsFontan procedureHeart failureVentricleHypoplastic left heart syndromeTricuspid valveHeart diseaseHypertrophic cardiomyopathyEBSTEIN ANOMALYTransplantationIn patientDiastoleMedicineEjection fraction
Publications 133
Myocardial strain offers new insights into ventricular performance, There are software packages from several different companies used to ascertain this, and little data is available in patients with single right ventricle (sRV) physiology. We aimed to compare the analysis of two strain software applications using a cohort of patients with sRV for both inter-vendor and inter-observer variability. Echocardiograms from 85 patients with sRV (122 separate studies) were prospectively evaluated. All ha...
Accurate assessment of the right ventricular (RV) volume and function is important in patients with hypoplastic left heart syndrome (HLHS). We sought to investigate the effect of ventriculotomy on the correlation of RV functional assessments by two-dimensional echocardiography (2DE) to cardiac magnetic resonance (CMR)-derived RV ejection fraction (EF) in patients with HLHS. A retrospective re-analysis of CMR imaging with matched 2DE was performed from the institutional HLHS registry. Echocardiog...
Left ventricular (LV) morphology may affect right ventricular (RV) function before and after Fontan palliation in patients with hypoplastic left heart syndrome (HLHS). We sought to assess the potential impact of LV morphology on RV function in patients with HLHS using cardiac magnetic resonance (CMR) imaging. A retrospective analysis of available CMR scans from all patients with HLHS was performed. LV morphology was categorized as absent/slit-like or globular/miniaturized. Volumetric analysis wa...
1 CitationsSource
#1Jeanne L. Theis (Mayo Clinic)H-Index: 11
#2Jessie J. Hu (Mayo Clinic)H-Index: 1
Last. Timothy M. Olson (Mayo Clinic)H-Index: 31
view all 8 authors...
BACKGROUND Hypoplastic left heart syndrome (HLHS) with risk of poor outcome has been linked to MYH6 variants, implicating overlap in genetic etiologies of structural and myopathic heart disease. METHODS Whole genome sequencing was performed in 197 probands with HLHS, 43 family members, and 813 controls. Data were filtered for rare, segregating variants in 3 index families comprised of an HLHS proband and relative(s) with cardiomyopathy. Whole genome sequencing data from cases and controls were c...
2 CitationsSource
#1Holst Kimberly A (UR: University of Rochester)H-Index: 1
#2Joseph A. Dearani (UR: University of Rochester)H-Index: 6
Last. Karen Cavanaugh (Mayo Clinic)H-Index: 2
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Abstract Background The objective of this study is to assess the safety and early impact of intramyocardial delivery of autologous bone marrow-derived mononuclear cells (BM-MNC) at time of surgical Ebstein repair. Methods Patients with EA (ages 6 months to 30 years) scheduled to undergo repair of the TV were eligible to participate in this open label, non-randomized Phase I clinical trial. BM-MNC target dose was 1-3 million cells/kg. Ten patients have undergone surgical intervention and cell del...
1 CitationsSource
#1Marie Vincenti (Mayo Clinic)H-Index: 1
#2Patrick W. O'Leary (Mayo Clinic)H-Index: 40
Last. Joan Wobig (Mayo Clinic)H-Index: 1
view all 7 authors...
Preservation of right ventricle function (RV) is a key to favorable outcome in Hypoplastic Left Heart Syndrome (HLHS), but methods to preserve or improve RV function are limited. Our goal was to assess the clinical and functional impact of autologous umbilical cord blood-derived mononuclear cells (UCB-MNC) therapy when given to patients with HLHS at Stage II surgery. UCB-MNC patients were enrolled prospectively in a phase I, FDA monitored trial as previously described (Burkhart et al., 2019). Ma...
2 CitationsSource
#1Alan Wang (Mayo Clinic)
#2M. Yasir Qureshi (Mayo Clinic)H-Index: 5
Last. Patrick W. O'Leary (Mayo Clinic)H-Index: 40
view all 7 authors...
Purpose: Right ventricular (RV) failure is a common cause of mortality and transplantation for patients with hypoplastic left heart syndrome (HLHS). The left ventricle (LV) morphology and size may affect the RV function before and after Fontan palliation. We sought to assess the impact of LV morphology on RV function in patients with HLHS using cardiac magnetic resonance (CMR) imaging data. Methods: Institutional HLHS registry was …
#1Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 10
#2Nathaniel W. Taggart (Mayo Clinic)H-Index: 14
Last. Timothy J. Nelson (Mayo Clinic)H-Index: 38
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The increased workload on single right ventricle (sRV) leads to increased risk of Fontan failure due to ventricular dysfunction. Conventional heart failure therapy has mixed results. This has led to increased interest in seeking alternative therapeutic strategies to improve ventricular function
#1Heather N. Anderson (Mayo Clinic)H-Index: 6
#2Joseph A. Dearani (Mayo Clinic)H-Index: 95
Last. Philip L. Wackel (Mayo Clinic)H-Index: 6
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Implantable loop recorders (ILR) are utilized for long-term rhythm monitoring. Typical placement of the Medtronic Reveal LINQ along the left parasternal border may compromise the quality and/or feasibility of future imaging studies. We sought to evaluate the utility of placing an ILR in the left anterior axillary position and the impact on the quality of cardiac imaging. We reviewed patients from May 2017 to June 2018 who had placement of a Reveal LINQ device in the left anterior axillary positi...
1 CitationsSource
#1Harold M. Burkhart (OU: University of Oklahoma)H-Index: 53
#2Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 10
Last. Joan WobigH-Index: 1
view all 35 authors...
Abstract Objectives Staged surgical palliation for hypoplastic left heart syndrome results in an increased workload on the right ventricle serving as the systemic ventricle. Concerns for cardiac dysfunction and long-term heart failure have generated interest in first-in-infant, cell-based therapies as an additional surgical treatment modality. Methods A phase 1 clinical trial was conducted to evaluate the safety and feasibility of direct intramyocardial injection of autologous umbilical cord blo...
20 CitationsSource