Sulan Luo
Hainan University
Binding siteSignal peptideMutantMolecular biologyReceptorConotoxinChemistryNicotinic agonistConus lividusAntagonistConus textileConusPeptideXenopusNicotinic acetylcholine receptora conotoxinRecombinant DNAAmino acidBiochemistryStereochemistryAcetylcholine receptorBiologyPharmacology
83Publications
15H-index
657Citations
Publications 77
Newest
#1Shuai Wang (Haida: Hainan University)H-Index: 2
#2Jie Ren (Xida: Guangxi University)
Last. Sulan Luo (Haida: Hainan University)H-Index: 15
view all 7 authors...
Abstract Head-to-tail cyclization is an effective strategy to improve the biological stability of peptides. The α-conotoxin [S9A]TxID is a peptide that inhibits α3β4 nAChR with high activity and selectivity. Herein, we established a method for cyclizing and oxidative folding of [S9A]TxID, and six cyclic analogues of [S9A]TxID were chemically synthesized with various linker lengths. We used the electrophysiology assay to measure activity values of these cyclic analogues, and obtained the most pot...
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#1Hong-Xiu Xiao (Haida: Hainan University)
#2Qing-Xiang Yan (Ontario Ministry of Natural Resources)H-Index: 2
Last. Sulan Luo (Haida: Hainan University)H-Index: 15
view all 9 authors...
The first total synthesis of marine natural product, (−)-majusculoic acid (1) and its seven analogs (9–15), was accomplished in three to ten steps with a yield of 3% to 28%. The strategy featured the application of the conformational controlled establishment of the trans-cyclopropane and stereochemical controlled bromo-olefination or olefination by Horner–Wadsworth–Emmons (HWE) reaction. The potential anti-inflammatory activity of the eight compounds (1 and 9–15) was evaluated by determining the...
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#1Shuai Wang (Haida: Hainan University)H-Index: 2
#2Xiaopeng Zhu (Haida: Hainan University)H-Index: 14
Last. Sulan Luo (Haida: Hainan University)H-Index: 15
view all 10 authors...
The α7 nicotinic acetylcholine receptor (nAChR) is present in the central nervous system and plays an important role in cognitive function and memory. α-Conotoxin LvIB, identified from genomic DNA of Conus lividus, its three isomers and four globular isomer analogues were synthesized and screened at a wide range of nAChR subtypes. One of the analogues, amidated [Q1G,ΔR14]LvIB, was found to be a potent blocker of rat α7 nAChRs. Importantly, it differentiates between α7 nAChRs of human (IC50: 1570...
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Last. Sulan LuoH-Index: 15
view all 9 authors...
α-Conotoxin TxIB, a selective antagonist of α6/α3β2β3 nicotinic acetylcholine receptor, could be a potential therapeutic agent for addiction and Parkinson’s disease. As a peptide with a complex pharmacophoric conformation, it is important and difficult to find a modifiable site which can be modified effectively and efficiently without activity loss. In this study, three xylene scaffolds were individually reacted with one pair of the cysteine residues ([1,3] or [2,4]), and iodine oxidation was us...
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#1Xiaodan LiH-Index: 4
#2Shen YouH-Index: 1
Last. Sulan LuoH-Index: 15
view all 7 authors...
Tobacco smoking has become a prominent health problem faced around the world. The α3β4 nicotinic acetylcholine receptor (nAChR) is strongly associated with nicotine reward and withdrawal symptom. α-Conotoxin TxID, cloned from Conus textile, is a strong α3β4 nAChR antagonist, which has weak inhibition activity of α6/α3β4 nAChR. Meanwhile, its analogue [S9K]TxID only inhibits α3β4 nAChR (IC50 = 6.9 nM), and has no inhibitory activity to other nAChRs. The present experiment investigates the effect ...
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#1Xiaopeng Zhu (Haida: Hainan University)H-Index: 14
#2Si Pan (Ministry of Education)H-Index: 1
Last. Sulan Luo (Haida: Hainan University)H-Index: 15
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The α3β2 and α3β4 nicotinic acetylcholine receptors (nAChRs) are widely expressed in the central and peripheral nervous systems, playing critical roles in various physiological processes and in such pathologies as addiction to nicotine and other drugs of abuse. α-Conotoxin LvIA, which we previously isolated from Conus lividus, modestly discriminates α3β2 and α3β4 rat nAChRs exhibiting a ∼17-fold tighter binding to the former. Here, alanine scanning resulted in two more selective analogues [N9A]L...
1 CitationsSource
#1Xinjia Li (Haida: Hainan University)H-Index: 1
#2Wanyi Chen (Haida: Hainan University)H-Index: 1
Last. Sulan Luo (Haida: Hainan University)H-Index: 15
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The venom of various Conus species is composed of a rich variety of unique bioactive peptides, commonly referred to as conotoxins (conopeptides). Most conopeptides have specific receptors or ion channels as physiologically relevant targets. In this paper, high-throughput transcriptome sequencing was performed to analyze putative conotoxin transcripts from the venom duct of a vermivorous cone snail species, Conus litteratus native to the South China Sea. A total of 128 putative conotoxins were id...
1 CitationsSource
#1Dongting Zhangsun (Haida: Hainan University)H-Index: 15
#2Sulan Luo (Haida: Hainan University)H-Index: 15
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#1Zhihua Sun (Haida: Hainan University)H-Index: 4
#2Jiaolin Bao (Haida: Hainan University)H-Index: 1
Last. Sulan Luo (Xida: Guangxi University)
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The α9-containing nicotinic acetylcholine receptor (nAChR) is increasingly emerging as a new tumor target owing to its high expression specificity in breast cancer. αO-Conotoxin GeXIVA is a potent antagonist of α9α10 nAChR. Nevertheless, the anti-tumor effect of GeXIVA on breast cancer cells remains unclear. Cell Counting Kit-8 assay was used to study the cell viability of breast cancer MDA-MD-157 cells and human normal breast epithelial cells, which were exposed to different doses of GeXIVA. Fl...
3 CitationsSource
#1Xincan Li (Haida: Hainan University)H-Index: 2
#2Shuai Wang (Haida: Hainan University)H-Index: 2
Last. Sulan Luo (Haida: Hainan University)H-Index: 15
view all 6 authors...
α-Conotoxin TxIB specifically blocked α6/α3β2β3 acetylcholine receptors (nAChRs), and it could be a potential probe for studying addiction and other diseases related to α6/α3β2β3 nAChRs. However, as a peptide, TxIB may suffer from low stability, short half-life, and poor bioavailability. In this study, cyclization of TxIB was used to improve its stability. Four cyclic mutants of TxIB (cTxIB) were synthesized, and the inhibition of these analogues on α6/α3β2β3 nAChRs as well as their stability in...
2 CitationsSource