Qingdi Q. Li
West Virginia University
CytotoxicityCyclin DCancerInternal medicineEndocrinologyPathologyCellMolecular biologyIntrinsic apoptosisCyclin AApoptosisCyclin D1Lung cancerCisplatinOvarian tumorOvarian cancerOncogeneCell cycleProgrammed cell deathCancer researchCell growthMedicineCell cultureBiologyCyclin ECell biologyPharmacology
33Publications
18H-index
1,213Citations
Publications 33
Newest
#1Qingdi Q. Li (WVU: West Virginia University)H-Index: 18
#2Gangduo Wang (WVU: West Virginia University)H-Index: 24
Last. Eddie Reed (USA: University of South Alabama)H-Index: 72
view all 6 authors...
β-Elemene, a new plant-derived anticancer agent with low toxicity, has been reported to be effective in the treatment of leukemia and solid tumors. In the current study, we explored the therapeutic application of β-elemene in sensitizing lung cancer cells to cisplatin. β-Elemene considerably enhanced the inhibitory effect of cisplatin on cell proliferation in a time- and dose-dependent manner in the human non-small cell lung cancer (NSCLC) cell lines H460 and A549. Furthermore, this effect of β-...
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Mammalian sterile 20–like kinase 1 (MST1) is a serine/threonine protein kinase that is activated in response to a wide variety of apoptotic stimuli and can cause apoptosis when over-expressed in mammalian cells. The physiological regulation and cellular targets of MST1 are not well understood. Using a yeast two-hybrid system, we identified human WW45 (hWW45, also called hSav1) as an MST1-binding protein. The association between the two proteins was confirmed by immunofluorescence and co-immunopr...
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#1Yongdong Feng (CUST: China University of Science and Technology)H-Index: 12
#2Jianhong WuH-Index: 4
Last. Jianping GongH-Index: 17
view all 12 authors...
Apoptosis results in cell death within 10 min after initiation by Bcl-2 family proteins and mitochondria; however, cells enter the apoptotic pathway at different elapsed times after being triggered. Intrinsic factors related to chemical or physical cell damage can initiate apoptosis at a specific cell cycle phase; it is not clear whether cells insulted via an extrinsic pathway also die at a specific cell cycle phase, or how apoptosis is related to cell cycle progression in cells. To illustrate t...
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Abstract Transmembrane tumor necrosis factor-alpha (mTNF-alpha) is known to be the precursor of soluble TNF-alpha (sTNF-alpha). mTNF-alpha can act as a ligand on the TNF receptor- (TNFR)- bearing cell through 'forward signaling' or as a receptor on the TNF producing cell through 'reverse signaling'. In the current study, we investigated the role of mTNF-alpha-mediated reverse signaling in regulating sTNF-alpha-induced activation of human monocytic U937 cells. We demonstrated that pretreatment wi...
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#1Yongping You (Tianjin Medical University General Hospital)H-Index: 2
#2Peiyu PuH-Index: 61
Last. Qingdi Q. LiH-Index: 18
view all 10 authors...
Telomerase is implicated in the development of cellular immortality and oncogenesis. It has been shown that telomerase activity is considerably higher in the tissue of many different cancers than in normal tissue, and that the inhibition or downregulation of telomerase activity can prevent the malignant proliferation of tumor cells. Antisense oligonucleotides have been widely used in suppressing the expression of genes and, therefore, in the present research, we evaluated the effect of antisense...
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#1Jing Wang (TJMC: Tongji Medical College)H-Index: 2
#2Bei HuH-Index: 2
Last. Junbo HuH-Index: 28
view all 12 authors...
The emergence of antibiotic-resistant bacterial strains still remains a significant problem for antimicrobial chemotherapy in the clinic. Bacterial viruses (bacteriophages or phages) have been suggested to be used as alternative therapeutic agents for bacterial infections. However, the efficacy of phage therapy in treating drug-resistant infections in humans is uncertain. Therefore in the present study, we examined the effectiveness of phages in the treatment of imipenem-resistant Pseudomonas ae...
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#1Jing Wang (TJMC: Tongji Medical College)H-Index: 2
#2Bei HuH-Index: 2
Last. Junbo HuH-Index: 28
view all 13 authors...
The emergence of multidrug-resistant bacteria has become a global crisis. Accumulating evidence shows that bacteriophages (phages) can rescue animals from a variety of lethal infections and be effective in treating drug-resistant infections in humans. Enterobacteriaceae, producing extended spectrum β-lactamase enzymes (ESBLs), are resistant to a broad range of β-lactamase antibiotics. One of the most common ESBL-producing gram-negative bacilli in Enterobacteriaceae is Escherichia coli. Since ESB...
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#1Chunzhao Yu (HUST: Huazhong University of Science and Technology)H-Index: 2
#2Junbo Hu (HUST: Huazhong University of Science and Technology)H-Index: 28
Last. Jianping Gong (HUST: Huazhong University of Science and Technology)H-Index: 17
view all 15 authors...
The use of 'double-thymidine block' was the first widely accepted method for inducing cell synchrony and remains one of the most effective and frequently used techniques for analyzing the cell cycle today. While thymidineis in itself an inhibitor of DNA replication, thymidine blocks are typically used to generate cell synchrony at the Gl/S boundary. We have previously presented the first evidence that shows the growth imbalance and altered expression levels of cyclins A, Bl, D3 and E in MOLT-4 c...
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#1Yongdong Feng (CUST: China University of Science and Technology)H-Index: 12
#2Junbo HuH-Index: 28
Last. Jianping GongH-Index: 17
view all 15 authors...
Caspase-3 is a critical effector caspase for apoptosis, which cleaves proteins, including cytoskeletal and associated proteins, kinases, and members of the Bcl-2 family of apoptosis-related proteins. This leads to changes in apoptotic morphology, such as membrane externalization and cytoplasm and nuclear condensation. It has been reported that pro-caspase-3 is activated in the cytosol. However, it remains obscure how caspase-3 activation correlates to serial changes in cell morphology during apo...
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#1Jinshun Zhao (WVU: West Virginia University)H-Index: 9
#2Jee Eun KimH-Index: 2
Last. Qingdi Q. Li (WVU: West Virginia University)H-Index: 18
view all 4 authors...
Abstract. Lung cancer is the most common cause of cancer mortality in both male and female patients in the United States of America, as well as in the rest of the world. Over one million people are diagnosed with lung cancer every year worldwide. The taxane is one of the most powerful classes of novel antitumor agents and has become an integral part of several commonly used chemotherapy regimens in lung cancer management over the past few years. Although the ability of taxanes to disrupt microtu...
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