Angelo Ravelli
I.M. Sechenov First Moscow State Medical University
JuvenileInternal medicineSurgeryPhysical therapyPediatricsRheumatologyImmunologyLupus erythematosusArthritisJuvenile dermatomyositisPolyarthritisDiseaseMEDLINEMacrophage activation syndromeJuvenile rheumatoid arthritisMethotrexateSeverity of illnessClinical trialMedicineGastroenterology
Publications 484
#1Andrea Angeletti (Istituto Giannina Gaslini)H-Index: 3
#2Stefano VolpiH-Index: 26
Last. Angelo RavelliH-Index: 90
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Neutrophil extracellular traps (NETs) are macromolecular structures programmed to trap circulating bacteria and viruses. The accumulation of NETs in the circulation correlates with the formation of anti-double-stranded (ds) DNA antibodies and is considered a causative factor for systemic lupus erythematosus (SLE). The digestion of DNA by DNase1 and DNases1L3 is the rate- limiting factor for NET accumulation. Mutations occurring in one of these two DNASE genes determine anti-DNA formation and are...
#1Andrea Angeletti (Istituto Giannina Gaslini)H-Index: 3
#2Maurizio Bruschi (Istituto Giannina Gaslini)H-Index: 30
Last. Federico Pratesi (UniPi: University of Pisa)H-Index: 25
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#1Chiara Trincianti (UniGe: University of Genoa)
#2Evert Hendrik Pieter van Dijkhuizen (Istituto Giannina Gaslini)H-Index: 3
Last. Pierre Quartier (Necker-Enfants Malades Hospital)H-Index: 64
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OBJECTIVE To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high disease activity (HDA) in children with oligoarthritis and with rheumatoid factor-negative polyarthritis, based on subjective disease assessment by the treating pediatric rheumatologist. METHODS The cutoffs definition cohort was composed of 1...
1 CitationsSource
#1Francesca Minoia (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 17
#2Angelo Ravelli (UniGe: University of Genoa)H-Index: 90
We are grateful to Wang et al 1 for testing our diagnostic score for macrophage activation syndrome (MAS)2 in their patients with adult onset Still disease (AOSD). Because it is increasingly recognised that systemic juvenile idiopathic arthritis (sJIA) and AOSD represent the same disease occurring at different ages3 4 and considering that the two illnesses share a similar risk for MAS, it is important to investigate whether the current diagnostic tools are applicable to both conditions. Wang and...
1 CitationsSource
#1Riccardo Papa (Istituto Giannina Gaslini)H-Index: 26
#2Marta Rusmini (Istituto Giannina Gaslini)H-Index: 9
Last. Patrizia Barone (University of Catania)H-Index: 10
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Abstract null null RAS-associated autoimmune leukoproliferative disease (RALD) is a rare immune dysregulation syndrome caused by somatic gain-of-function mutations of either NRAS or KRAS gene in hematopoietic cells. We describe a 27-year-old patient presenting at 5 months of age with recurrent infections and generalized lymphadenopathy who developed a complex multi-organ autoimmune syndrome with hypogammaglobulinemia, partially controlled with oral steroids, hydroxichloroquine, mofetil mycopheno...
#1Elio Castagnola (Istituto Giannina Gaslini)H-Index: 53
#2Marcello Mariani (UniGe: University of Genoa)H-Index: 1
Last. Angelo Ravelli (Istituto Giannina Gaslini)H-Index: 90
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Vaccines are a fundamental weapon against a number of infections that may cause severe disease or sequelae, both in the absence or presence of etiologic therapy, or have a high socio-economic impact in terms of hospital admissions or requests for medical examination. COVID-19, a serious infection due to SARS-CoV-2, exemplifies all these characteristics.
#2Claudia BracagliaH-Index: 21
Last. Angelo Ravelli (Istituto Giannina Gaslini)H-Index: 90
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Objective null To evaluate in real-life the effectiveness and safety of canakinumab in Italian patients with systemic juvenile idiopathic arthritis (sJIA). null Methods null A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and adverse events were collected at baseline, after 6 and 12 months from starting canakinumab. The effectiveness primary outcome was clinical inactive disease (CID) off glucocorticoids (GCs) treatment at 6 months....
#1Stefano Lanni (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 15
#2Denise Pires Marafon (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 11
Last. Giovanni Filocamo (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 22
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OBJECTIVE: To compare frequency of joint and tendon disease on ultrasound (US) and clinical examination (CE), and to investigate agreement between US and CE in ankles with clinically active juvenile idiopathic arthritis (JIA). METHODS: US and CE were performed independently in the joint and tendon compartments of 105 ankles. Grey-scale (GS) US and power Doppler (PD) US joint abnormalities were scored on a 4-point semiquantitative scale. A joint with a GS score >/= 2 and/or a PD score >/= 1 was d...
#1Marta Mazzoni (UniGe: University of Genoa)H-Index: 2
#2Angela Pistorio (Istituto Giannina Gaslini)H-Index: 73
Last. Clara Malattia (UniGe: University of Genoa)H-Index: 29
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OBJECTIVES To define the prevalence of MRI subclinical synovitis in a large cohort of JIA patients in clinical remission and to evaluate its predictive value in terms of disease flare and joint deterioration. METHODS Ninety patients with clinically inactive JIA who underwent a contrast-enhanced (CE) MRI of a previously affected joint were retrospectively included. Each joint was evaluated for synovitis, tenosynovitis and bone marrow oedema (BMO). Baseline and follow-up radiographs were assessed ...
#1Silvia Rosina (Istituto Giannina Gaslini)H-Index: 6
#2Valentina Natoli (UniGe: University of Genoa)H-Index: 2
Last. Angelo Ravelli (Istituto Giannina Gaslini)H-Index: 90
view all 6 authors...
INTRODUCTION The search for biomarkers in juvenile idiopathic arthritis (JIA) is a promising and rapidly expanding field of investigation. The biomarkers identified so far may help to dissect the clinical heterogeneity of the illness, measure the level of disease activity, predict clinical remission, relapse, response to medications, course over time, complications, and forestall disease flares. AREAS COVERED We provide a summary of the most recent advances in the development and application of ...