Roberto Salvia
University of Verona
CancerInternal medicineRadiologySurgeryPathologyOncologyRetrospective cohort studyPancreatitisIntraductal papillary mucinous neoplasmCarcinomaPancreatectomyPancreasPancreaticoduodenectomyPancreatic cancerPancreatic fistulaAdenocarcinomaDistal pancreatectomyGeneral surgeryMedicineGastroenterology
472Publications
52H-index
7,653Citations
Publications 471
Newest
#1Raffaella Casolino (Glas.: University of Glasgow)H-Index: 2
#2Salvatore PaiellaH-Index: 23
Last. Fieke E.M. Froeling (Glas.: University of Glasgow)H-Index: 15
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PURPOSETo analyze the prevalence of homologous recombination deficiency (HRD) in patients with pancreatic ductal adenocarcinoma (PDAC).MATERIALS AND METHODSWe conducted a systematic review and meta...
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#1Michelle R. Goulart (QMUL: Queen Mary University of London)H-Index: 6
#2Jennifer Watt (QMUL: Queen Mary University of London)H-Index: 5
Last. Catrin Cox (Cardiff University)H-Index: 1
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Pancreatic ductal adenocarcinoma (PDAC), characterized by dense desmoplastic stroma laid down by pancreatic stellate cells (PSC), has no reliable diagnostic biomarkers for timely detection. A multi-center cohort of PDAC patients and controls (chronic pancreatitis, intra-ductal papillary neoplasms, gallstones and otherwise healthy) donated serum in an ethically approved manner. Serum PTX3 above 4.34 ng/mL has a higher sensitivity (86%, 95% confidence interval (CI): 65-97%) and specificity (86%, 9...
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#1Pascal Probst (Heidelberg University)H-Index: 22
#2Felix J Hüttner (Heidelberg University)H-Index: 16
Last. Marco Del Chiaro (Anschutz Medical Campus)H-Index: 31
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BACKGROUND Pancreatic surgery is associated with considerable morbidity and, consequently, offers a large and complex field for research. To prioritize relevant future scientific projects, it is of utmost importance to identify existing evidence and uncover research gaps. Thus, the aim of this project was to create a systematic and living Evidence Map of Pancreatic Surgery. METHODS PubMed, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for all...
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#1Rita T. LawlorH-Index: 31
#2Paola MattioloH-Index: 3
Last. Roberto SalviaH-Index: 52
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Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation sequencing. In the case of high values, it indicates a potential response to immunotherapy. In this systematic review, we assessed the potential predictive role of high-TMB in pancreatic ductal adenocarcinoma (PDAC), as well as the histo-molecular features of high-TMB PDAC. H...
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#1Isabella FrigerioH-Index: 17
#2Salvatore PaiellaH-Index: 23
Last. G. FiorentiniH-Index: 14
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Abstract null null Background null Local ablation of pancreatic cancer has been suggested as an option to manage locally advanced pancreatic cancer (LAPC) although no robust evidence has been published to date to support its application. The aim of this study is to compare overall survival (OS) and progression-free survival (PFS) in patients receiving both radiofrequency ablation (RFA) and conventional chemoradiotherapy (CHRT) with patients receiving CHRT only. null null null Methods null This i...
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#1Giacomo Deiro (University of Verona)H-Index: 2
#2M De Pastena (University of Verona)H-Index: 1
Last. Alessandro Esposito (University of Verona)H-Index: 14
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BACKGROUND The Japanese difficulty scoring system (DSS) was developed to assess the difficulty of laparoscopic distal pancreatectomy (LDP). The study aimed to validate a modified DSS (mDSS) in a European high-volume center. METHODS Patients' clinical data underwent LDP for benign and malignant pancreatic lesion between September 2013 and February 2020 were reviewed. Expert laparoscopic surgeons performed the procedures. The mDSS consisted of seven variables, such as type of operation, malignancy...
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#1N. Surci (Medical University of Vienna)
Last. Claudio BassiH-Index: 110
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Abstract null null Background null Incidental discovery of pancreatic cystic neoplasms (PCLs) is a common and steadily increasing occurrence. The aim of this study was to investigate a cohort of patients presenting with incidentally detected PCLs which were not included in a surveillance protocol, and to compare their risk of malignant evolution with that of systematically surveilled lesions. null null null Materials and methods null A population of PCLs which did not receive surveillance over a...
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#1Giovanni Marchegiani (University of Verona)H-Index: 29
#2Stefano Andrianello (University of Verona)H-Index: 16
Last. Roberto Salvia (University of Verona)H-Index: 52
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BACKGROUND Despite the low malignant potential of pancreatic mucinous cystic neoplasms (MCNs), surgery is still performed. The aim of this pragmatic study was to assess the outcome of surgery and surveillance for patients presenting with a presumed MCN at the first evaluation. METHODS Data for patients with a presumed MCN observed from 2000 to 2016 at the Verona Pancreas Institute and San Raffaele Hospital were extracted from prospective databases. The endpoints were risk of malignancy at pathol...
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#1Giovanni Marchegiani (University of Verona)H-Index: 29
#2Tommaso Pollini (University of Verona)H-Index: 8
Last. Roberto Salvia (University of Verona)H-Index: 52
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Importance The progression of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas to malignant disease is still poorly understood. Observational and surgical series have failed to provide comprehensive information. Objective To identify dynamic variables associated with the development of malignant neoplasms by combining pathological features with data from preoperative repeated observations. Design, Setting, and Participants The Crossover Observational Multicentric Study included a...
1 CitationsSource
#1Laura PasquardiniH-Index: 15
#2Nunzio CennamoH-Index: 18
Last. Alessandra BossiH-Index: 28
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Postoperative pancreatic fistula (POPF), the major driver of morbidity and mortality following pancreatectomy, is caused by an abnormal communication between the pancreatic ductal epithelium and another epithelial surface containing pancreas-derived, enzyme-rich fluid. There is a strong correlation between the amylase content in surgically-placed drains early in the postoperative course and the development of POPF. A simple and cheap method to determine the amylase content from the drain effluen...
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