Shing-Hwa Liu
National Taiwan University
EndocrinologyUnfolded protein responseMolecular biologyEndoplasmic reticulumKinaseChemistryApoptosisOxidative stressHonokiolToxicityProgrammed cell deathCancer researchNitric oxideViability assayBiochemistryMAPK/ERK pathwayMedicineBiologyCell biologyPharmacology
295Publications
44H-index
6,729Citations
Publications 297
Newest
#1Cheng-Chin HuangH-Index: 1
#2Ching-Yao Yang (NTU: National Taiwan University)H-Index: 33
Last. Chun-Fa Huang (AU: Asia University (Taiwan))H-Index: 17
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4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), a major active metabolite of bisphenol A (BPA), is generated in the mammalian liver. Some studies have suggested that MBP exerts greater toxicity than BPA. However, the mechanism underlying MBP-induced pancreatic β-cell cytotoxicity remains largely unclear. This study demonstrated the cytotoxicity of MBP in pancreatic β-cells and elucidated the cellular mechanism involved in MBP-induced β-cell death. Our results showed that MBP exposure signific...
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#1Gong-Jhe Wu (TMU: Taipei Medical University)H-Index: 12
#2Yih-Giun Cherng (TMU: Taipei Medical University)H-Index: 16
Last. Ruei-Ming ChenH-Index: 33
view all 6 authors...
Our previous study showed that estrogen can induce mitochondrial adenosine triphosphate (ATP) synthesis-associated gene expressions and osteoblast maturation. Genistein, a phytoestrogenic isoflavone that is widely found in various foods and traditional herb products, is beneficial for osteogenesis by selectively triggering estrogen receptor alpha (ER[Formula: see text] expression. In this study, we further investigated the mechanisms of genistein-induced energy production and osteoblast activati...
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#1Chun-Fa Huang (PRC: China Medical University (PRC))H-Index: 17
#2Shing-Hwa Liu (NTU: National Taiwan University)H-Index: 44
Last. Ya-Wen Chen (PRC: China Medical University (PRC))H-Index: 21
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Abstract Bisphenol A (BPA) is recognized as a harmful pollutant in the worldwide. Growing studies have reported that BPA can cause adverse effects and diseases in human, and link to a potential risk factor for development of neurodegenerative diseases (NDs). 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), which generated in the mammalian liver after BPA exposure, is a major active metabolite of BPA. MBP has been suggested to exert greater toxicity than BPA. However, the molecular mechanism of...
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#1Po-Ming Chow (NTU: National Taiwan University)H-Index: 6
#2Yu-Wei Chang (NTU: National Taiwan University)H-Index: 4
Last. Kuo-How Huang (NTU: National Taiwan University)H-Index: 28
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Urothelial carcinoma (UC) is the most common type of bladder cancer, with a 5-year survival rate of only 4.6% in metastatic UC. Despite the advances related to immune-checkpoint inhibitor therapy, chemotherapy remains the standard of care for metastatic diseases, with a 50% response rate. The covalent cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 interferes with transcription machinery and is reported to be effective in cancers without targetable mutations. Therefore, we investigated the thera...
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#1Cheng-Hsuan Ho (NTU: National Taiwan University)
#2Ahmad Khaldun Ismail (UKM: National University of Malaysia)H-Index: 7
Last. Shih-Hung Tsai (NDMC: National Defense Medical Center)H-Index: 16
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The incidence of acute compartment syndrome (ACS) following snakebite envenomation may be seriously overestimated in Taiwan. Snakebite-induced ACS is difficult to determine solely by clinical exami...
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#1Shing-Hwa Liu (NTU: National Taiwan University)H-Index: 44
#2Rui-Yi Chen (NTOU: National Taiwan Ocean University)H-Index: 1
Last. Meng-Tsan Chiang (NTOU: National Taiwan Ocean University)H-Index: 16
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Chitosan and its derivative, chitosan oligosaccharide (CO), possess hypolipidemic and anti-obesity effects. However, it is still unclear if the mechanisms are different or similar between chitosan and CO. This study was designed to investigate and compare the effects of CO and high-molecular-weight chitosan (HC) on liver lipogenesis and lipid peroxidation, adipose lipolysis, and intestinal lipid absorption in high-fat (HF) diet-fed rats for 12 weeks. Rats were divided into four groups: normal co...
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#1Kuan-Lin Kuo (NTU: National Taiwan University)H-Index: 7
#2Wei-Chou Lin (NTU: National Taiwan University)H-Index: 27
Last. Kuo-How Huang (NTU: National Taiwan University)H-Index: 28
view all 10 authors...
Chemotherapy with gemcitabine plus cisplatin remains the mainstay of treatment for metastatic urothelial carcinoma (UC); however, drug resistance occurs in most patients and eventually leads to treatment failure. In this study, we investigated the role of cyclin-dependent kinase 7 (CDK7) regulation in the treatment of human UCs. Moreover, we studied the effect of THZ1, a CDK7 inhibitor, alone and in combination with gemcitabine, on UCs and explored the underlying mechanism. Immunohistochemical s...
#1Shin-Hun Juang (PRC: China Medical University (PRC))H-Index: 18
#2Min-Tsang HsiehH-Index: 9
Last. Hsin Yi HungH-Index: 15
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Constitutive androstane receptor (CAR) activation has found to ameliorate diabetes in animal models. However, no CAR agonists are available clinically. Therefore, a safe and effective CAR activator would be an alternative option. In this study, sixty courmarin derivatives either synthesized or purified from Artemisia capillaris were screened for CAR activation activity. Chemical modifications were on position 5,6,7,8 with mono-, di-, tri-, or tetra-substitutions. Among all the compounds subjecte...
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#1Chang-Mu ChenH-Index: 11
#2Yao-Pang Chung (NTU: National Taiwan University)H-Index: 3
Last. Shing-Hwa LiuH-Index: 44
view all 8 authors...
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